Ateganosine
CAS 789-61-7
MF C10H13N5O3S MW 283.31 g/mol
2′-deoxy-6-thioguanosine
nucleoside analogue, antineoplastic
- 6-THIO-2′-DEOXYGUANOSINE
- 2′-Deoxythioguanosine
- TGdR
- Thioguanine deoxyriboside
- KR0RFB46DF
- NSC-71261
Ateganosine is a telomerase inhibitor[1] and apoptosis inducer currently under investigation for the treatment of various cancers, including non-small cell lung cancer (NSCLC).[2]
Beta-Thioguanine Deoxyriboside is a thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells. (NCI04)
- THIO Sequenced With Cemiplimab in Advanced NSCLCCTID: NCT05208944Phase: Phase 2Status: RecruitingDate: 2025-05-31
- A Phase III Study With THIO + Cemiplimab vs Chemotherapy as 3rd Line Treatment in Advanced/Metastatic NSCLCCTID: NCT06908304Phase: Phase 3Status: Not yet recruitingDate: 2025-04-08
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References
- Eglenen-Polat B, Kowash RR, Huang HC, Siteni S, Zhu M, Chen K, et al. (January 2024). “A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer”. Nature Communications. 15 (1) 672. Bibcode:2024NatCo..15..672E. doi:10.1038/s41467-024-44861-8. PMC 10803750. PMID 38253555.
- “Ateganosine”. PatSnap.
| Clinical data | |
|---|---|
| Other names | 2′-Deoxythioguanosine |
| Identifiers | |
| IUPAC name | |
| CAS Number | 789-61-7 |
| PubChem CID | 3000603 |
| DrugBank | DB18117 |
| ChemSpider | 2272164 |
| UNII | KR0RFB46DF |
| KEGG | D13071 |
| ChEMBL | ChEMBL3250476 |
| CompTox Dashboard (EPA) | DTXSID4021345 |
| Chemical and physical data | |
| Formula | C10H13N5O3S |
| Molar mass | 283.31 g·mol−1 |
| 3D model (JSmol) | Interactive image |
| SMILES | |
| InChI | |
////////Ateganosine, nucleoside analogue, antineoplastic, 6-THIO-2′-DEOXYGUANOSINE, 2′-Deoxythioguanosine, TGdR, Thioguanine deoxyriboside, KR0RFB46DF, fast track designation, NSC-71261, NSC 71261