Category «2020 APPROVALS»

Abametapir アバメタピル , абаметапир , أباميتابير , 阿巴甲吡 ,

It’s only fair to share…   Abametapir アバアバメタピル , абаметапир , أباميتابير , 阿巴甲吡 , 5,5′-dimethyl-2,2′-bipyridine, 6,6′-Bi-3-picoline BRN 0123183 HA 44 HA-44 HA44 Formula C12H12N2 CAS 1762-34-1 Mol weight 184.2371 Xeglyze, FD APPROVED 24/7/2020 Pediculicide, Metalloproteinase inhibitor   Disease Head lice infestation Originator Hatchtech DeveloperDr Reddys Laboratories; Hatchtech ClassAntiparasitics; Heterocyclic compounds; Pyridines; Small molecules Mechanism of ActionChelating agents; Metalloprotease inhibitors Registered Pediculosis 27 Jul …

Bulevirtide acetate

It’s only fair to share…   Bulevirtide acetate (N-Myristoyl-glycyl-L-threonyl-L-asparaginyl-L-leucyl-L-seryl-L-valyl-Lprolyl-L-asparaginyl-L-prolyl-L-leucyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-prolyl-L-aspartyl-L-histidyl-Lglutaminyl-L-leucyl-L-aspartyl-L-prolyl-L-alanyl-L-phenylalanyl-glycyl-L-alanyl-L-asparaginyl-L-seryl-Lasparaginyl-L-asparaginyl-Lprolyl-L-aspartyl-L-tryptophanyl-L-aspartyl-L-phenylalanyl-L-asparaginyl-L-prolylL-asparaginyl-L-lysyl-L-aspartyl-L-histidyl-L-tryptophanyl-L-prolyl-L-glutamyl-L-alanyl-L-asparaginyl-L-lysylL-valylglycinamide, acetate salt. molecular formula C248H355N65O72, molecular mass is 5398.9 g/mol ブレビルチド酢酸塩; APROVED 2020/7/31, EU, Hepcludex MYR GmbH Antiviral, Entry inhibitor   Disease Hepatitis delta virus infection Bulevirtide is a 47-amino acid peptide with a fatty acid, a myristoyl residue, at the N-terminus and an amidated C-terminus. The active substance …

Nifurtimox

It’s only fair to share… Nifurtimox Formula C10H13N3O5S CAS 23256-30-6 Mol weight 287.2923 FDA APPROVED, 2020/8/6, LAMPIT Antiprotozoal   Disease Chagas disease IUPAC Name 3-methyl-4-[(E)-[(5-nitrofuran-2-yl)methylidene]amino]-1lambda6-thiomorpholine-1,1-dione SMILES CC1CS(=O)(=O)CCN1\N=C\C1=CC=C(O1)[N+]([O-])=O SYN Danong Chen, Glenn Rice. 2013. Novel formulations of nitrofurans including nifurtimox with enhanced activity with lower toxicity.US20150140089A1 melting point (°C) 177-183 https://www.chemicalbook.com/ChemicalProductProperty_US_CB3903922.aspx OriginatorBayer ClassAntiprotozoals; Nitrofurans; Small molecules; Thiamorpholines; Thiazines …

Imlifidase

It’s only fair to share… MDSFSANQEI RYSEVTPYHV TSVWTKGVTP PANFTQGEDV FHAPYVANQG WYDITKTFNG KDDLLCGAAT AGNMLHWWFD QNKDQIKRYL EEHPEKQKIN FNGEQMFDVK EAIDTKNHQL DSKLFEYFKE KAFPYLSTKH LGVFPDHVID MFINGYRLSL TNHGPTPVKE GSKDPRGGIF DAVFTRGDQS KLLTSRHDFK EKNLKEISDL IKKELTEGKA LGLSHTYANV RINHVINLWG ADFDSNGNLK AIYVTDSDSN ASIGMKKYFV GVNSAGKVAI SAKEIKEDNI GAQVLGLFTL STGQDSWNQT N Imlifidase イムリフィダーゼ; Formula C1575H2400N422O477S6 CAS 1947415-68-0 Mol weight 35070.8397 EMA APPROVED, 2020/8/25, Idefirix Pre-transplant treatment to make patients with donor …

Clascoterone

It’s only fair to share… Clascoterone (1R,3aS,3bR,9aR,9bS,11aS)-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate Formula C24H34O5 CAS 19608-29-8 Mol weight 402.5238 FDA APPROVED, 2020/8/26, Winlevi クラスコステロン; Anti-acne, Androgen receptor antagonist Clascoterone, sold under the brand name Winlevi, is an antiandrogen medication which is used topically in the treatment of acne.[1][2][3] It is also under development for the treatment of androgen-dependent scalp hair loss.[2] The medication is used as a cream by application to the skin, …

Copper Cu 64 dotatate, 銅(Cu64)ドータテート;

It’s only fair to share… Copper Cu 64 dotatate 銅(Cu64)ドータテート; UNII-N3858377KC N3858377KC Copper 64-DOTA-tate Copper Cu-64 dotatate Copper dotatate Cu-64 Diagnostic (neuroendocrine tumors), Radioactive agent Formula C65H86CuN14O19S2. 2H CAS:  1426155-87-4 Mol weight 1497.1526 FDA APPROVED 2020. 2020/9/3. Detectnet 2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-10-(carboxylatomethyl)-7-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;copper-64(2+) Cuprate(2-)-64Cu, (N-(2-(4,10-bis((carboxy-kappaO)methyl)-7-(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl-kappaN1,kappaN4,kappaN7,kappaN10)acetyl)-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoni Copper Cu 64 dotatate, sold under the brand name Detectnet, is a radioactive diagnostic agent indicated for …

Amisulpride, アミスルプリド ,

It’s only fair to share… Amisulpride FDA 2020, Barhemsys APPROVED, 2020/2/27 Name Amisulpride (INN); Deniban (TN); Solian (TN) アミスルプリド; Formula C17H27N3O4S CAS 71675-85-9 Mol weight 369.479 Antipsychotic, Dopamine receptor antagonist, Neuropsychiatric agent amisulpride(标准品) 275-831-7 [EINECS] Synthesis ReferenceUS4401822 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide Amisulpride CAS Registry Number: 71675-85-9 CAS Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide Additional Names: 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-o-anisamide; aminosultopride Manufacturers’ Codes: DAN-2163 Trademarks: Deniban (Synthelabo); Socian (Synthelabo); Solian (Synthelabo); Sulamid (Baldacci) Molecular Formula: C17H27N3O4S …

リメゲパント硫酸塩; Rimegepant sulfate

It’s only fair to share… Rimegepant Molecular FormulaC28H28F2N6O3 Monoisotopic mass534.219116 Da 1289023-67-1 [RN] 1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester 9751 BMS 927711 Antimigraine, Calcitonin receptor-like receptor antagonist Treatment of migraine Rimegepant sulfate (USAN) リメゲパント硫酸塩; Formula (C28H28F2N6O3)2. H2SO4. 3H2O CAS 1374024-48-2 Mol weight 1221.2386   Nurtec ODT, FDA 2020, 2020/2/27 fda approved Biohaven Pharmaceuticals developed Rimegepant, also known as …

Delgocitinib

It’s only fair to share… Delgocitinib デルゴシチニブ 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile 1,6-Diazaspiro(3.4)octane-1-propanenitrile, 3-methyl-beta-oxo-6-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-, (3S,4R)- 3-((3S,4R)-3-methyl-6-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1,6-diazaspiro(3.4)octan-1-yl)-3-oxopropanenitrile   Formula C16H18N6O CAS 1263774-59-9 Mol weight 310.3537 Approved, Japan 2020, Corectim, 2020/1/23, atopic dermatitis, Japan Tobacco (JT) Torii UNII-9L0Q8KK220, JTE-052, LP-0133, ROH-201, 9L0Q8KK220, LEO 124249A, LEO 124249, HY-109053 CS-0031558, D11046, GTPL9619, JTE-052A, JTE052 Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent …

Dotinurad ドチヌラド

It’s only fair to share…   Dotinurad ドチヌラド (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone Formula C14H9Cl2NO4S CAS 1285572-51-1 Mol weight 358.1966 PMDA, Urece, APROVED JAPAN 2020/1/23, Antihyperuricemic 305EB53128UNII-305EB53128 1285572-51-1, VOFLAIHEELWYGO-UHFFFAOYSA-N HY-109031 CS-0030545 Dotinurad is a urate transporter inhibitor. Patents WO 2011040449   https://patents.google.com/patent/WO2011040449A1/en Uric acid is produced by metabolizing a purine produced by the degradation of a nucleic acid in the body and adenosine …