anti bacterial – Drug Approvals International

Cefoperazone

It’s only fair to share… Cefoperazone Molecular FormulaC25H27N9O8S2 Average mass645.667 Da Product Ingredients INGREDIENT UNII CAS INCHI KEY Cefoperazone sodium 5FQG9774WD 62893-20-3 NCFTXMQPRQZFMZ-WERGMSTESA-M (6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7-[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 263-749-4 [EINECS], 4742 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo- , (6R,7R)- [ACD/Index Name] 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)- 62893-19-0 [RN] 7-[D-(-)-a-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl)acetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic Acid 7U75I1278D Experimental Properties PROPERTY VALUE SOURCE melting point (°C) 188-190 Saikawa, I., Takano, …

Meropenem

It’s only fair to share… Meropenem CAS number96036-03-2 IUPAC Name (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid WeightAverage: 383.463 Monoisotopic: 383.151491615 Chemical FormulaC17H25N3O5S Antibiotic SM 7338 ICI 194660 SM 7338 CAS Registry Number: 96036-03-2 CAS Name: (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Additional Names: (1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid Molecular Formula: C17H25N3O5S Molecular Weight: 383.46 Percent Composition: C 53.25%, H 6.57%, N 10.96%, O 20.86%, S 8.36% Literature References: Carbapenem antibiotic. Prepn: M. …

BIAPENEM

It’s only fair to share… Biapenem Molecular FormulaC15H18N4O4S Average mass350.393 Da Biapenern CL 186-815 LJ C10,627 LJ C10627 LJC 10627 MFCD00864863 [MDL number] omegacin YR5U3L9ZH1 (4R,5S,6S)-3-((6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate [4R-[4a,5b,6b(R*)]]-6-[[2-Carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5 H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt 120410-24-4 [RN] 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt [ACD/Index Name] 6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt 7074 (4R,5S,6S)-3-(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate TL8000539 UNII:YR5U3L9ZH1 UNII-YR5U3L9ZH1 биапенем بيابينام 比阿培南 P12-KU4322-43245-1 INDIA CDSCO APPROVED 25 SEPT 2021, BDR PHARMA, …

Clarithromycin

It’s only fair to share… Clarithromycin Synonyms:A-56268, TE-031, 6-O-methylerythromycin, ATC:J01FA09 Use:macrolide antibiotic Chemical name:6-O-methylerythromycin Formula:C38H69NO13 MW:747.96 g/mol CAS-RN:81103-11-9 81103-11-9 klacid XL / Klaricid XL / Macladin / Naxy / Veclam / Zeclar (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione Synthesis Reference Jih-Hua Liu, David A. Riley, “Preparation of crystal form II of clarithromycin.” U.S. Patent US5844105, issued May, 1997. US5844105 Product Ingredients INGREDIENT UNII CAS INCHI KEY Clarithromycin citrate 16K08R7NG0 848130-51-8 MDRWXDRMSKEMRE-AZFLODHXSA-N Clarithromycin …

Erythromycin

It’s only fair to share… Erythromycin NSC-55929 UNII63937KV33D CAS number114-07-8 Molecular FormulaC37H67NO13 Average mass733.927 Da эритромицин [Russian] [INN] إيريثروميسين [Arabic] [INN] 红霉素 [Chinese] [INN] IUPAC Name (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione Synthesis ReferenceTakehiro Amano, Masami Goi, Kazuto Sekiuchi, Tomomichi Yoshida, Masahiro Hasegawa, “Process for preparing erythromycin A oxime or a salt thereof.” U.S. Patent US5274085, issued October, 1966. US5274085 Erythromycin CAS Registry Number: 114-07-8 Additional …

Dirithromycin

It’s only fair to share… Dirithromycin LY 237216 LY-237216 (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3-ethyl-2,10-dihydroxy-7-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one UNII1801D76STL CAS number62013-04-1 Synthesis Reference Counter FT, Ensminger PW, Preston DA, Wu CY, Greene JM, Felty-Duckworth AM, Paschal JW, Kirst HA: Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin. Antimicrob Agents Chemother. 1991 Jun;35(6):1116-26. Pubmed. Dirithromycin CAS Registry …

Amikacin sulfate

It’s only fair to share… Amikacin sulfate アミカシン硫酸塩 , BB K 8 Formula C22H43N5O13. 2H2SO4 CAS 39831-55-5 FREE 37517-28-5 Mol weight 781.7595 EU APPROVED, 2020/10/27, Arikayce liposomal Antibacterial, Protein biosynthesis inhibitor (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid Amikacin CAS Registry Number: 37517-28-5 CAS Name: O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[6-amino-6-deoxy-a-D-glucopyranosyl-(1®4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Additional Names: 1-N-[L(-)-4-amino-2-hydroxybutyryl]kanamycin A Molecular Formula: C22H43N5O13 Molecular Weight: 585.60 Percent Composition: C 45.12%, H 7.40%, N 11.96%, O 35.52% Literature References: Semisynthetic aminoglycoside …

FDA approves new antibiotic Xenleta (lefamulin) to treat community-acquired bacterial pneumonia

It’s only fair to share… FDA approves new antibiotic Xenleta (lefamulin) to treat community-acquired bacterial pneumonia The U.S. Food and Drug Administration today approved Xenleta (lefamulin) to treat adults with community-acquired bacterial pneumonia. “This new drug provides another option for the treatment of patients with community-acquired bacterial pneumonia, a serious disease,” said Ed Cox, M.D., …