Category «organic chemistry»

Dr. Vinayak Pagar( GUEST BLOGGER) Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds

It’s only fair to share… Discussing my paper…….. Metal-catalyzed cycloadditions of alkenyldiazo reagents are useful tools to access carbo- and heterocycles.[1] These diazo compounds are chemically sensitive toward both Brønsted orLewis acids. Their reported cycloadditions rely heavily on the formation of metal carbenes to initiate regio- and stereoselective [3+n] cycloadditions (n=2–4) with suitable dipolarophiles.[2–4] A noncarbene route was postulated for a …

Regioselective access of alkylidendibenzo[c,f]oxocine framework via cyclocarbopalladation/cross-coupling cascade reactions and reductive Heck strategy

It’s only fair to share… Regioselective access of alkylidendibenzo[c,f]oxocine framework via cyclocarbopalladation/cross-coupling cascade reactions and reductive Heck strategy New J. Chem., 2017, Advance Article DOI: 10.1039/C6NJ03825E, Paper Tapas Ghosha   a Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany E-mail: tapas.ghosh@uni-wuerzburg.de,tapasghosh.chem@gmail.com Tel: +49-931-31-81629 New J. Chem., 2017, Advance Article DOI: 10.1039/C6NJ03825E Palladium-catalyzed …

Asymmetric total synthesis of (-)-δ-lycorane

It’s only fair to share… 1H NMR 13C NMR Org. Chem. Front., 2017, Advance Article DOI: 10.1039/C7QO00021A, Research Article Junliang Wang, Jianneng Li, Xianwang Shen, Cong Dong, Jun Lin, Kun Wei A first asymmetric synthesis of (-)-δ-lycorane by using a chiral bifunctional squaramide-catalysed cascade reaction is reported. Asymmetric total synthesis of (−)-δ-lycorane Junliang Wang,ab   Jianneng …

(Z)-3-Chloro-3-(3′-fluorophenyl)-acrylonitrile

It’s only fair to share… cas 1192875-03-8, 181.59 C9 H5 Cl F N 2-Propenenitrile, 3-chloro-3-(3-fluorophenyl)-, (2Z)- WO 2009133389 IV V VI II Example 1: Synthesis of (Z)-3-Chloro-3-(3-fluorophenyl)-acrylonitrile from 3′-Fluoroacetophenone. To a solution of 3′-fluoroacetophenone (80.0 g, 0.579 mol) in 7V,N-dimethyl formamide (560 ml) at about 400C was added phosphoryl chloride (92.50 ml, 1.01 mol) dropwise, maintaining …