Valdetamide

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Image result for Valdetamide

CAS Registry Number: 512-48-1

CAS Name: 2,2-Diethyl-4-pentenamide

Additional Names: diethylallylacetamide

Trademarks: Novonal (Hoechst)

Molecular Formula: C9H17NO

Molecular Weight: 155.24

Percent Composition: C 69.63%, H 11.04%, N 9.02%, O 10.31%

Literature References: Description: Bockmühl, Schaumann, Dtsch. Med. Wochenschr. 54, 270 (1928). Pharmacokinetics and metabolism: H. Uehleke, M. Brinkschulte-Freitas, Arch. Pharmacol. 302, 11 (1978). TLC determn in urine: E. Klug, P. Toffel, Arzneim.-Forsch. 29, 1651 (1979).

Properties: White powder, mp 75-76°. Sol in 120 parts water; freely sol in alcohol, ether.

Melting point: mp 75-76°

Therap-Cat: Sedative, hypnotic.

Keywords: Sedative/Hypnotic; Amides.

Valdetamid (Valdetamide)

Structural formula

UV – spectrum

Conditions : Concentration – 50 mg / 100 ml
The solvent designation schedule methanol

Water

0.1 M HCl

0.1M NaOH

maximum absorption
ε

IR – spectrum

Wavelength (μm)
Wave number (cm -1 )

Range
10 largest peaks:
Peak 53 55 57 67 69 81 112 126 127 140
Value 152 848 115 141 929 156 286 999 338 238

References

  • UV and IR Spectra. H.-W. Dibbern, RM Muller, E. Wirbitzki, 2002 ECV

  • NIST / EPA / NIH Mass Spectral Library 2008

  • Handbook of Organic Compounds. NIR, IR, Raman, and UV-Vis Spectra Featuring Polymers and Surfactants, Jr., Jerry Workman.Academic Press, 2000.

  • Handbook of ultraviolet and visible absorption spectra of organic compounds, K. Hirayama. Plenum Press Data Division, 1967.

Brief background information

Salt ATC Formula MM CAS
N05C 9 H 17 NO 155.24 g / mol 512-48-1

Using

  • hypnotic

Classes substance

  • Amides

Synthesis Way

Synthesis of a)

Trade names

A country Tradename Manufacturer
Germany Arantxa Hoechst
Betadorm-H Woelm
insomnia ICN
Nokturetten Starke
New Dolestan Much
Ukraine no no

Formulations

  • dragees 50 mg;

  • 300 mg Tablets

References

  • DRP 473 329 (IG Farben; appl 1925.).

  • DRP 616 876 (IG Farben; appl 1930.).

  • DRP 622 875 (IG Farben; appl 1931.).

  • GB 253,950 (IG Farben; appl 1926;.. D-prior 1925).

1H NMR PREDICT

13C NMR PREDICT

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