Category «Antihypertensives»

SC-52458, FORASARTAN

It’s only fair to share… SC-52458, FORASARTAN Molecular FormulaC23H28N8 Average mass416.522 Da PHASE 2,  PFIZER, HYPERTENSION 145216-43-9 [RN] 5-[(3,5-Dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-yl)phenyl]pyridine 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]pyridine форасартан [Russian] [INN], فوراسارتان[Arabic][INN], 福拉沙坦[Chinese][INN] 065F7WPT0B [DBID] 7415 [DBID] UNII-065F7WPT0B [DBID] SC 52458 [DBID] Type-1 angiotensin II receptor Forasartan, otherwise known as the compound SC-52458, is a nonpeptide angiotensin II receptor antagonist (ARB, AT1 receptor blocker).[2][3][4][5] Forasartan, a specific angiotensin II antagonist, is used alone or with …

Naftopidil

It’s only fair to share… Naftopidil 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol C24H28N2O3, 392.49 CAS 57149-07-2 KT-611, Flivas, Avishot 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol Naftopidil (Flivas), BM-15275 Naftopidil CAS Registry Number: 57149-07-2 CAS Name: 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Additional Names: RS-1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol; 1-(2-methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine Manufacturers’ Codes: KT-611 Trademarks: Avishot (Kanebo); Flivas (Asahi) Molecular Formula: C24H28N2O3 Molecular Weight: 392.49 Percent Composition: C 73.44%, H 7.19%, N 7.14%, O 12.23% Literature References: a1-Adrenergic blocker and serotonin (5HT1A) receptor agonist. Prepn: E. C. Witte et al., DE 2408804; eidem, US 3997666 (1975, 1976 …

SHR-0532

It’s only fair to share… SHR-0532 CAS 2166329-09-3 C24 H26 N4 O5 . C4 H6 O6 2-Pyridinecarboxamide, 5-cyano-N-[1-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-4-piperidinyl]-4-methoxy-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) FREE FORM 1945997-37-4 C24 H26 N4 O5 450.49 2-Pyridinecarboxamide, 5-cyano-N-[1-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-4-piperidinyl]-4-methoxy- 5-Cyano-N-[1-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-4-piperidinyl]-4-methoxy-2-pyridinecarboxamide KCNJ potassium channel-1 inhibitor, Hypertension; Renal insufficiency Originator Jiangsu Hengrui Medicine Co. Class Antihypertensives Mechanism of Action Undefined mechanism Preclinical Hypertension 03 Jun 2019 Jiangsu Hengrui Medicine Co. plans a phase I trial for Hypertension (PO) in June 2019 (NCT03971929) …