Efficient and Stereoselective Syntheses of Isomerically Pure 4-Aminotetrahydro-2H-thiopyran 1-Oxide Derivatives

It’s only fair to share… trans-4-Aminotetrahydro-2H-thiopyran 1-Oxide Methanesulfonate (trans–3d-MsOH) Compound ……………….afforded trans-3d-MsOH (20 g, 68%) as a white crystalline solid. 1H NMR (300 MHz, DMSO-d6) δ 1.60–1.76 (2H, m), 2.16–2.29 (2H, m), 2.31 (3H, s), 2.68–2.81 (2H, m), 3.13–3.23 (2H, m), 3.27–3.35 (1H, m), 7.86 (3H, brs). 13C NMR (75 MHz, D2O) δ 24.98, 38.51, …

Tropylium salts as efficient organic Lewis acid catalysts for acetalization and transacetalization reactions in batch and flow

It’s only fair to share… Tropylium salts as efficient organic Lewis acid catalysts for acetalization and transacetalization reactions in batch and flow Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01519D, Communication D. J. M. Lyons, R. D. Crocker, D. Enders, T. V. Nguyen Tropylium salts were reported as organic-Lewis acids to efficiently catalyze acetalization reactions in …

CP 11

It’s only fair to share…     Scheme 10 Synthesis of C60-PGN and C60-GAP. It has been calculated that the enthalpy of formation of Cp-5 is 2782.2 kJ mol−1, while its detonation velocity and pressure are 3282 km s−1 and 4.443 GPa, respectively.112 Upon complete combustion, the total heat of combustion for Cp-5 is 2.17 …

HNIW, CL 20, 六硝基六氮杂异伍兹烷

It’s only fair to share…   HNIW, CL-20 Molecular FormulaC6H6N12O12 Average mass438.185 Da 1,3,4,7,8,10-hexanitrooctahydro-1H-5,2,6-(epiminomethanetriylimino)imidazo[4,5-b]pyrazine CAS 135285-90-4 Hexanitrohexaazaisowurtzitane 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane Octahydro-1,3,4,7,8,10-hexanitro-5,2,6-(iminomethenimino)-1H-imidazo[4,5-b]pyrazine HNIW 六硝基六氮杂异伍兹烷 ABOUT AUTHOR Tomasz Gołofit Warsaw University of Technolog… , Warsaw Thermochemistry, Physical Chemistry, Materials Chemistry Warsaw University of Technology Department of Energized Materials Warsaw, mazowieckie, Poland Staff Paweł Maksimowski Wincenty Skupiński Wojciech Pawłowski Waldemar Tomaszewski …

Lanabecestat (formerly known as AZD3293 or LY3314814)

It’s only fair to share… Lanabecestat Molecular FormulaC26H28N4O Average mass412.527 Da Dispiro[cyclohexane-1,2′-[2H]indene-1′(3′H),2”-[2H]imidazol]-4”-amine, 4-methoxy-5”-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1′R,4β)- (1r,1’R,4R)-4-Methoxy-5”-methyl-6′-[5-(1-propin-1-yl)-3-pyridinyl]-3’H-dispiro[cyclohexane-1,2‘-indene-1’,2”-imidazol]-4”-amin (1r,1’R,4R)-4-Methoxy-5”-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-3’H-dispiro[cyclohexane-1,2‘-indene-1’,2”-imidazol]-4”-amine (lr,l’R,4R)- 4-methoxy-5″-methyl-6′-[5-(prop-l-yn-l-yl)pyridin-3-yl]-3’H- dispiro[cyclohexane-l,2′-inden-l’2′-imidazole]-4″-amine (lr,4r)-4-Methoxy-5″-methyl-6′-(5-prop-l-yn-l-ylpyridin-3-yl)-3’H-dispiro[cyclohexane- l,2′-indene-l’,2″-imidazol]- “-amine CAS 1383982-64-6 AZD3293 Dispiro[cyclohexane-1,2′-[1H]indene-1′(3’H),2”-[2H]imidazol]-4”-amine, 4-methoxy-5”-methyl-6‘-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1‘R)- Lanabecestat LY3314814 UNII:X8SPJ492VF, AZ-12304146 Beta amyloid antagonist; Beta secretase 1 inhibitor; Beta secretase 2 inhibitor Fast Track (1α,1’R,4β)-4-Methoxy-5”-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]dispiro[cyclohexane-1,2′-[2H]indene-1′(3’H),2”-[2H]imidazol]-4”-amine (1,4-trans,1’R)-4-methoxy-5”-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2′-indene-1′,2”-imidazol]-4”-amine (1r,1’R,4R)-4-methoxy-5”-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2′-indene-1′,2”-imidazol]-4”-amine Lanabecestat (formerly known as AZD3293 or LY3314814) is …

Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature

It’s only fair to share… Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature Green Chem., 2017, 19,2506-2509 DOI: 10.1039/C7GC00883J, Communication Aurelien Adenot, Evan B. Landstrom, Fabrice Gallou, Bruce H. Lipshutz Nanomicelles housing a terminal alkyne and azide are delivered to ppm Cu-containing nanoparticles that catalyse click reactions in …

TILOGLIPTIN

It’s only fair to share… PRESENTING 2 MOLECULES………..I AM NOT SURE WHICH IS TITLE MOLECULE EMAIL ME amcrasto@gmail.com Molecular Formula: C25H27N7O Molecular Weight: 441.539 g/mol 2-[(3R)-3alpha-Aminopiperidino]-3-(2-butynyl)-5-(4-methyl-2-quinazolinylmethyl)-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-4-one CAS 1428445-40-2 REF Bioorganic & Medicinal Chemistry (2013), 21(7), 1749-1755.   NEXT ONE……………… CAS 1415912-31-0 1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-([1,2,5]thiadiazolo[3,4-b]pyridin-5-ylmethyl)- 8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-([1,2,5]thiadiazolo[3,4-b]pyridin-5-ylmethyl)-1H-purine-2,6-dione 8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-([1,2,5]thiadiazolo[3,4-b]pyridin-5-ylmethyl)purine-2,6-dione Molecular Formula: C21H23N9O2S Molecular Weight: 465.536 g/mol REF CN 102807568, CN 105315301,  WO 2016019868 Salt……….. CAS 1874255-95-4 C21 H23 N9 O2 …

TEGAFUR

It’s only fair to share… Tegafur CAS 17902-23-7 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)- Molecular Weight,200.17, MF C8 H9 F N2 O3 172-173 °C Miyashita, Osamu; Chemical & Pharmaceutical Bulletin 1981, 29(11), PG 3181-90 Uracil, 5-fluoro-1-(tetrahydro-2-furyl)- Utefos Venoterpine WY1559000 YR0450000 5-fluoro-1-tetrahydrofuran-2-ylpyrimidine-2,4(1H,3H)-dione Carzonal N1-(2′-Furanidyl)-5-fluorouracil Synonyms:Ftorafur ATC:L01BC03 EINECS:241-846-2 LD50:800 mg/kg (M, i.v.); 775 mg/kg (M, p.o.); 685 mg/kg (R, i.v.); 930 …

FDA approves first generic Strattera (atomoxetine) for the treatment of ADHD

It’s only fair to share… FDA approves first generic Strattera (atomoxetine) for the treatment of ADHD 05/30/2017 04:49 PM EDT The U.S. Food and Drug Administration today approved the first generic versions of Strattera (atomoxetine) to treat attention-deficit/hyperactivity disorder (ADHD) in pediatric and adult patients. 05/30/2017 The U.S. Food and Drug Administration today approved the …

FDA approves first drug Actemra (tocilizumab) to specifically treat giant cell arteritis

It’s only fair to share… FDA approves first drug to specifically treat giant cell arteritis 05/22/2017 The U.S. Food and Drug Administration today expanded the approved use of subcutaneous Actemra (tocilizumab) to treat adults with giant cell arteritis. This new indication provides the first FDA-approved therapy, specific to this type of vasculitis. May 22, 2017 …