Tucatinib

It’s only fair to share…   Tucatinib ツカチニブ; N6-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-N4-(3-methyl-4-{[1,2,4]triazolo[1,5-a]pyridin-7-yloxy}phenyl)quinazoline-4,6-diamine Formula C26H24N8O2 CAS 937263-43-9 Mol weight 480.5212 To treat advanced unresectable or metastatic HER2-positive breast cancer Drug Trials Snapshot FDA APPROVED 4/17/2020 Tukysa ARRY 380 ARRY-380 ONT 380 ONT-380 Tucatinib (INN),[1] sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer.[2][3] It was developed by Array …

Ripretinib

It’s only fair to share… Ripretinib リプレチニブ; Formula C24H21BrFN5O2 CAS 1442472-39-0 Mol weight 510.3582 Antineoplastic, Receptor tyrosine kinase inhibitor US FDA APPROVED 2020/5/15 QUINLOCK NAME DOSAGE STRENGTH ROUTE LABELLER MARKETING START MARKETING END Qinlock Tablet 50 mg Oral Deciphera Pharmaceuticals. Llc Not applicable Not applicable Qinlock Tablet 50 mg/1 Oral Deciphera Pharmaceuticals, LLC 2020-05-15 Not applicable …

REPROXALAP

It’s only fair to share… REPROXALAP レプロキサラップ; ADX-102 2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol C12H13ClN2O, 236.7 g/mol CAS 916056-79-6 UNII-F0GIZ22IJH 2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol Phase 3 Clinical Aldeyra Therapeutics is developing reproxalap, which binds and traps free aldehydes, formulated using Captisol technology licensed from Ligand Pharmaceuticals as an eye drop formulation, for treating acute noninfectious anterior uveitis, allergic conjunctivitis and dry eye syndrome.   PATENT …

Lercanidipine hydrochloride,

It’s only fair to share… Lercanidipine CAS Registry Number: 100427-26-7 CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester Additional Names: methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate; methyl 1,1-dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; masnidipine Molecular Formula: C36H41N3O6 Molecular Weight: 611.73 Percent Composition: C 70.68%, H 6.76%, N 6.87%, O 15.69% Literature References: Dihydropyridine calcium channel blocker. Prepn: D. Nardi et al., EP 153016; eidem, US 4705797 (1985, 1987 both to Recordati). Pharmacology: G. Bianchi et al., Pharmacol. Res. 21, 193 (1989). …

Spinosad

It’s only fair to share… Spinosad Spinosyn A: The chemical name is: 1H-as-Indaceno[3,2- d]oxacyclododecin-7,a5-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl-alphaL-mannopyranosyl)oxy]-13-[[2R,5S,6R)-5-(dimethylamino) tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-metyl-, (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)- Spinosyn D: The chemical name is: 1H-as-Indaceno[3,2- d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl-alphaL-mannopyranosyl)oxy]-13-[[2R,5S,6R)-5-(dimethylamino) tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimetyl-, (2S,3aSR,5aS,5bS,9S,13S,14R,16aS,16bS)- 168316-95-8 Molecular FormulaC83H132N2O20 Average mass1477.938 Da Comfortis Conserve EC 434-300-1 Natroba NaturaLyte Spinosad Tracer Tracer Naturalyte UNII-XPA88EAP6V XDE 105 Natroba (Spinosad) Suspension 0.9% ParaPro Pharma New Drug …

Triheptanoin

It’s only fair to share…   Triheptanoin Approved US FDA 30/6/2020 Dojolvi UX 007 Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation.4 In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, …

MILVEXIAN

It’s only fair to share…   MILVEXIAN ミルベクシアン; Molecular Formula,C28-H23-Cl2-F2-N9-O2 Molecular Weight, 626.4441 BMS-986177, JNJ-70033093; JNJ-3093, WHO 11401 CAS 1802425-99-5 (5R,9S)-9-(4-(5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl)-6-oxopyrimidin-1(6H)-yl)-21-(difluoromethyl)-5-methyl-21H-3-aza-1(4,2)-pyridina-2(5,4)-pyrazolacyclonaphan-4-one Prevention and Treatment of Thromboembolic Disorders  Milvexian, also known as BMS-986177, is a blood coagulation factor XIa inhibitor.Bristol-Myers Squibb , in collaboration with  Janssen , is developing milvexian (BMS-986177, JNJ-70033093; JNJ-3093), an antithrombotic factor XIa …

Cetuximab sarotalocan sodium

It’s only fair to share… Cetuximab Sarotalocan Sodium (Genetical Recombination) Cetuximab Sarotalocan Sodium is an antibody-drug-conjugate (molecular weight: 156,000-158,000) consisting of tetrasodium salt of Sarotalocan (6-({[3-({(OC-6-13)-bis({3-[bis(3-sulfopropyl)(3-sulfonatopropyl)azaniumyl]propyl}dimethylsilanolato-κO,κO‘)[(phtalocyaninato(2-)κN29,κN30,κN31,κN32)-1-yl]silicon}oxy)propoxy]carbonyl}amino)hexanoyl (C70H96N11O24S6Si3; molecular weight: 1,752.22)) attached to an average of 2-3 Lys residues of Cetuximab. [2166339-33-7 , Cetuximab sarotalocan] Cetuximab sarotalocan sodium JAPAN 2020/9/25APPROVED AKALUX Antineoplastic セツキシマブサロタロカンナトリウム (遺伝子組換え) Originator Aspyrian Therapeutics Developer Rakuten Medical …

ENZALUTAMIDE

It’s only fair to share…   4-(6-chloro-1-oxo-3-thioxo-9,9a-dihydro-1H-imidazo[1,5-a]indol-2(3H)-yl)-2-(trifluoromethyl)-benzonitrile Drug Name: Enzalutamide Research Code: MDV-3100 Trade Name: Xtandi® MOA: Androgen receptor inhibitor Indication: Prostate cancer Status: Approved Company: Medivation (Originator) , Astellas Sales: $2,100.8 Million (Y2015);  $1,247.3 Million (Y2014); $546 Million (Y2013); $148.8 Million (Y2012); ATC Code: L01 Approved Countries or AreaUpdate Date:2015-07-29  US EU JP Approval …

Enarodustat

It’s only fair to share…   Enarodustat エナロデュスタット JTZ 951 Formula C17H16N4O4 CAS 1262132-81-9 Mol weight 340.3333 PMDA 2020/9/25 APPROVED ENAROY Anti-anemic, Hypoxia inducible factor-prolyl hydroxylase (HIF-PH) inhibitor Originator Japan Tobacco Developer Japan Tobacco; JW Pharmaceutical Class Acetic acids; Amides; Antianaemics; Pyridones; Small molecules; Triazoles Mechanism of Action Hypoxia-inducible factor-proline dioxygenase inhibitors Preregistration Anaemia 27 Dec …