Category «synthesis»

Hypericin

It’s only fair to share…     Hypericin Hypericin is a naphthodianthrone, an anthraquinone derivative which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John’s wort).[2][3] Hypericin is believed to act as an antibiotic, antiviral[2] and non-specific kinaseinhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine. It was initially believed that the anti-depressant pharmacological …

Ruthenium-Catalyzed Tandem C–H Fluoromethylation/Cyclization of N-Alkylhydrazones with CBr3F: Access to 4-Fluoropyrazoles

It’s only fair to share… 4-Fluoropyrazoles are accessible in a single step from readily available aldehyde-derived N-alkylhydrazones through double C–H fluoroalkylation with tribromofluoromethane (CBr3F). RuCl2(PPh3)3 has been proven to be the most efficient catalyst for this transformation when compared to a range of other Cu-, Pd-, or Fe-based catalyst systems. Alexis Prieto Alexis Prieto, Didier Bouyssi*, and Nuno Monteiro*  …

Continuous-Flow Preparation of γ-Butyrolactone Scaffolds, 2-(5,5-dimethyl-2-oxotetrahydrofuran-3- yl)acetic acid

It’s only fair to share… (5,5-dimethyl-2-oxotetrahydrofuran-3-yl)acetic acid 2-(5,5-Dimethyl-2-oxotetrahydrofuran-3-yl)acetic acid 2-carboxymethyl-4-methyl-4-pentanolide, Cas 412298-86-3       2-(5,5-Dimethyl-2-oxotetrahydrofuran-3-yl)acetic acid (4a). 1H NMR (DMSO-d6, 400 MHz): δ = 3.20 – 3.10 (m, 1H), 2.62 (dd, J = 17.1, 4.4 Hz, 1H), 2.54 – 2.45 (m, 1H), 2.31 – 2.21 (m, 1H), 1.84 (t, J = 12.0 Hz, 1H), 1.39 …

2,4-dimorpholinocyclopent-2-enone

It’s only fair to share…   1465003-25-1 cas   2,4-dimorpholinocyclopent-2-enone (1b): 1H NMR (300 MHz, CDCl3) 6.24 (d, J = 2.9 Hz, 1H, COC=CH), 3.78 (t, J = 4.7 Hz, 4H, morpholine), 3.73 (t, J = 4.7 Hz, 4H, morpholine), 3.73-3.72 (m, 1H, COCH2CHN), 3.15-3.14 (m, 4H, morpholine), 2.54-2.52 (m, 4H, morpholine), 2.49-2.48 (m, 1H, …

Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C-H) with indoles (sp2 C-H) using a heterogeneous mesoporous manganese oxide catalyst

It’s only fair to share… Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C-H) with indoles (sp2 C-H) using a heterogeneous mesoporous manganese oxide catalyst Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01919J, Communication B. Dutta, V. Sharma, N. Sassu, Y. Dang, C. Weerakkody, J. Macharia, R. Miao, A. R. Howell, S. L. Suib We disclose a novel, …

Polymers from biomass: one pot two-step synthesis of furilydenepropanenitrile derivatives with MIL-100(Fe) catalyst

It’s only fair to share… Polymers from biomass: one pot two-step synthesis of furilydenepropanenitrile derivatives with MIL-100(Fe) catalyst Catal. Sci. Technol., 2017, 7,3008-3016 DOI: 10.1039/C7CY00463J, Paper Anastasia Rapeyko, Karen S. Arias, Maria J. Climent, Avelino Corma, Sara Iborra Monomers from biomass have been prepared from HMF and methylene active compounds through a one pot process using …

CuI nanoparticles as recyclable heterogeneous catalysts for C-N bond formation reactions

It’s only fair to share…   CuI nanoparticles as recyclable heterogeneous catalysts for C-N bond formation reactions Catal. Sci. Technol., 2017, 7,2857-2864 DOI: 10.1039/C7CY00832E, Paper Manoranjan Kumar, Vinod Bhatt, Onkar S. Nayal, Sushila Sharma, Vishal Kumar, Maheshwar S. Thakur, Neeraj Kumar, Rajaram Bal, Bikram Singh, Upendra Sharma Herein, copper iodide nanoparticles (NPs) are reported for the …

3-Phenylpropionic acid

It’s only fair to share…     3-Phenylpropionic acid (2z) 1 1) Jiang, X.; Zhang, J.; Ma. S. J. Am. Chem. Soc. 2016, 138, 8344 Yield: 94% (142 mg), white solid. Melting point: 47-49 °C (lit.18 49 °C) (18) Helavi, V. B.; Solabannavar, S. B.; Desai, U. V.; Mane, R. B. J. Chem. Research 2003, …

syn-3,5-Dihydroxy Hexanoate

It’s only fair to share…   pure 8 (2.4 g, HPLC purity, 92%). [α]D25 = −41.3 (c = 1.0, CHCl3), >99.5% de.(8g, 9) 1H NMR (CDCl3, 400 MHz), δ/ppm: 1.47 (s, 9H), 1.71–1.75 (m, 2H), 2.42–2.44 (m, 2H), 2.54–2.56 (m, 2H), 3.71 (brs, 2H), 4.18–4.22 (m, 1H), 4.26–4.31 (m, 1H).   t-butyl 6-cyano-(5R)-hydroxy-3-oxo-hexanoate t-Butyl-6-cyano-(3R,5R)-dihydroxyhexanoate is an advanced chiral precursor for the …