Category «synthesis»

3-Phenylpropionic acid

It’s only fair to share…     3-Phenylpropionic acid (2z) 1 1) Jiang, X.; Zhang, J.; Ma. S. J. Am. Chem. Soc. 2016, 138, 8344 Yield: 94% (142 mg), white solid. Melting point: 47-49 °C (lit.18 49 °C) (18) Helavi, V. B.; Solabannavar, S. B.; Desai, U. V.; Mane, R. B. J. Chem. Research 2003, …

syn-3,5-Dihydroxy Hexanoate

It’s only fair to share…   pure 8 (2.4 g, HPLC purity, 92%). [α]D25 = −41.3 (c = 1.0, CHCl3), >99.5% de.(8g, 9) 1H NMR (CDCl3, 400 MHz), δ/ppm: 1.47 (s, 9H), 1.71–1.75 (m, 2H), 2.42–2.44 (m, 2H), 2.54–2.56 (m, 2H), 3.71 (brs, 2H), 4.18–4.22 (m, 1H), 4.26–4.31 (m, 1H).   t-butyl 6-cyano-(5R)-hydroxy-3-oxo-hexanoate t-Butyl-6-cyano-(3R,5R)-dihydroxyhexanoate is an advanced chiral precursor for the …

(7R, 8S, 8′S, 7″S, 8″R)-abiesol A 4″-O-β-d-glucopyranoside, capselloside.

It’s only fair to share… (7R, 8S, 8′S, 7″S, 8″R)-abiesol A 4″-O-β-d-glucopyranoside, and it was named capselloside. Capselloside (1): Brownish gum; [α]25D −34.0 (c = 0.05, MeOH); UV (MeOH) λmax (log ε) 280 (1.4), 228 (3.3), 214 (3.1) nm; IR (KBr) νmax 3261, 2946, 2816, 1638, 1489, 1261 cm−1; CD (MeOH) λmax (Δ ε) 291 (−), 280 (−) 257 (−) 230 (−) …

Synthesis, characterization and anti-inflammatory evaluation of novel substituted tetrazolodiazepine derivatives

It’s only fair to share… SRM University Department of Chemistry Chennai, Tamil Nadu, India 3b R = NITRO http://nopr.niscair.res.in/handle/123456789/42358   Dr. S. Sathishkumar Assistant Professor in Chemistry, Kongu Engineering College, Perundurai, Erode – 638052 DR. HELEN P. KAVITHA Dr. Helen P. Kavitha Professor and Head of the Department E-mail: helen.p@rmp.srmuniv.ac.in Area: Chemistry Affiliation: Department of Chemistry, Ramapuram Campus, SRM …

NaBH4, twin screw technology (i.e., granulator, melt extruder, etc.) to yield the desired product in a continuous manner

It’s only fair to share…   In this work the application of green chemistry principles such as process intensification and the replacement of reagents and solvents to more benign alternatives were coupled with the advantages of continuous manufacturing. The reduction of lipophilic aromatic aldehydes using an aqueous alkaline solution of NaBH4 was achieved by means of …

Ascaridole

It’s only fair to share…   Scheme 2. Photo-Oxidation of α-terpinene 1 to Ascaridole 2 and the Common Byproduct p-Cymene 3 Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory Darren S. Lee† , Zacharias Amara†, Charlotte A. Clark†, Zeyuan Xu‡, Bruce Kakimpa‡, Herve P. Morvan‡, Stephen J. Pickering‡, Martyn Poliakoff*†, and Michael W. George*†§ †School of Chemistry, ‡Department of Mechanical, Materials and Manufacturing Engineering, University of …

Cp2TiCl: An Ideal Reagent for Green Chemistry?

It’s only fair to share…     The development of Green Chemistry inevitably involves the development of green reagents. In this review, we highlight that Cp2TiCl is a reagent widely used in radical and organometallic chemistry, which shows, if not all, at least some of the 12 principles summarized for Green Chemistry, such as waste …

Green Synthesis of Veratraldehyde Using Potassium Promoted Lanthanum–Magnesium Mixed Oxide Catalyst

It’s only fair to share…   Veratraldehyde is an important chemical used in perfumery, agrochemical, and pharmaceutical industries. Current processes of manufacture of veratraldehyde use homogeneous catalysts, which make them highly polluting, creating problems of disposal of effluents and product purity. In the current work, veratraldehyde was synthesized from O-alkylation of vanillin with an environmentally …

Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

It’s only fair to share…   Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01289F, Paper Zhanhui Yang, Zhongpeng Zhu, Renshi Luo, Xiang Qiu, Ji-tian Liu, Jing-Kui Yang, Weiping Tang A highly efficient iridium catalyst is developed for the chemoselective reduction …