Category «Uncategorized»

PF-06650833

It’s only fair to share… PF-06650833 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide CAS 1817626-54-2 Chemical Formula: C18H20FN3O4 Molecular Weight: 361.3734 Originator Pfizer Class Anti-inflammatories; Antirheumatics Mechanism of Action Interleukin-1 receptor-associated kinase inhibitors Phase II Rheumatoid arthritis Phase I Lupus vulgaris 01 Aug 2018 Pfizer completes a phase II trial in Rheumatoid arthritis (Treatment-experienced) in USA, Ukraine, Taiwan, Serbia, Russia, Romania, Poland, Mexico, South Korea, Georgia, Bosnia-Herzegovina, …

PF 06650808

It’s only fair to share… . Picture credit….Bethany Halford PF 06650808 CAS 1822383-80-1 A biologic for cancer treatment (Pfizer Inc.) Originator Pfizer Class Antineoplastics Mechanism of Action Notch-3 receptor antagonists No development reported Solid tumours 24 Jun 2018 Biomarkers information updated 28 Apr 2018 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease) in USA (IV) 01 Jul 2017 Pfizer …

Beclabuvir

It’s only fair to share… BMS-791325, Beclabuvir IN PHASE 2 for Hepatitis C (HCV) An NS5B inhibitor. BMS-791325 preferably is CAS 958002-33-0 958002-36-3 (as hydrochloride) C36 H45 N5 O5 S, 659.838 Cycloprop(d)indolo(2,1-a)(2)benzazepine-9-carboxamide, 12-cyclohexyl-N-((dimethylamino)sulfonyl)-4b,5,5a,6-tetrahydro-3-methoxy-5a-((3-methyl-3,8-diazabicyclo(3.2.1)oct-8-yl)carbonyl)-, (4bS,5aR)- (4bS,5aR)-12-Cyclohexyl-N-(dimethylsulfamoyl)-3-methoxy-5a-((3-methyl-3,8-diazabicyclo(3.2.1)oct-8-yl)carbonyl)-4b,5,5a,6-tetrahydrocyclopropa(d)indolo(2,1-a)(2)benzazepine-9-carboxamide (4bS,5aR)-12-Cyclohexyl-N-(dimethylsulfamoyl)-3-methoxy-5a-((3-methyl-3,8-diazabicyclo(3.2.1)oct-8-yl)carbonyl)-4b,5,5a,6-tetrahydrocyclopropa(d)indolo(2,1-a)(2)benzazepine-9-carboxamide (1aR,12bS)-8-Cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide Cycloprop [d] indolo [2, 1 -a] [2]benzazepine-5-carboxamide, 8-cyclohexyl-N- [(dimethylamino)sulfonyl]-l,la,2,12b-tetrahydro-ll-methoxy-la-[(3-methyl-3,8- diazabicyclo[3.2.1]oct-8-yl)carbonyl]-, (laR,12bS)- Bristol-Myers Squibb (Originator) RNA-Directed RNA Polymerase (NS5B) …

Vibegron ビベグロン

It’s only fair to share…   Vibegron, MK-4618, KRP 114V UNII-M5TSE03W5U; M5TSE03W5U; D10433 1190389-15-1;  cas no Molecular Formula: C26H28N4O3   Molecular Weight: 444.52552 Merck Sharp & Dohme Corp.  INNOVATOR phase 2 for the treatment of overactive bladder  (6S)-N-[4-([(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide (6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carboxamide Target-based Actions Beta 3 adrenoceptor agonist Indications Overactive bladder; Urinary incontinence UPDATE 2018/9/21  pmda Beova JAPAN 2018Kyorin Pharmaceutical, under license …

Omadacycline tosylate

It’s only fair to share… Omadacycline tosylate 728.8521, C29H40N4O7. C7H8O3S CAS: 1075240-43-5 389139-89-3 FREE FORM FDA 2018/10/3, Nuzyra オマダサイクリントシル酸塩; UNII-5658Y89YCD (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-{[(2,2-dimethylpropyl)amino]methyl}-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide 4-methylbenzenesulfonate (1:1) 1075240-43-5 [RN] 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-, 4-methylbenzenesulfonate (1:1) (salt) 5658Y89YCD Amadacycline tosylate PTK 0796 / PTK-0796 Omadacycline FREE FORM, 389139-89-3 FREE FORM Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and …

Savolitinib

It’s only fair to share… Savolitinib CAS 1313725-88-0, Molecular Formula, C17-H15-N9, Molecular Weight, 345.3685 1H-1,2,3-Triazolo(4,5-b)pyrazine, 1-((1S)-1-imidazo(1,2-a)pyridin-6-ylethyl)-6-(1-methyl-1H-pyrazol-4-yl)- AZD-6094 AZD6094 HMPL-504 HMPL504 Savolitinib Savolitinib [INN] UNII-2A2DA6857R Volitinib HM 5016504 1H-1,2,3-Triazolo[4,5-b]pyrazine, 1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)- 1-[(1S)-1-(Imidazo[1,2-a]pyridin-6-yl)ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine [ 2A2DA6857R 9935 Phase III, AstraZeneca Hutchison China MediTech (Chi-Med), Cancer, kidney (renal cell carcinoma, papillary) A c-Met kinase inhibitor with antineoplastic activity. NCI: volitinib. An orally bioavailable inhibitor of …

Epitinib

It’s only fair to share… Epitinib succinate; HMPL-813; Huposuan yipitini 1203902-67-3, 430.50, C24 H26 N6 O2 1-Piperazinecarboxamide, 4-ethyl-N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]- 4-Ethyl-N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]-1-piperazinecarboxamide Cancer; Glioblastoma; Non-small-cell lung cancer Epitinib is in phase I clinical trials by Hutchison MediPharma for the treatment of solid tumours. Epitinib succinate is an oral EGFR tyrosine kinase inhibitor in early clinical development at Hutchison China MediTech (Chi-Med) for the …

Eluxadoline, エルクサドリン ,элуксадолин ,إيلوكسادولين ,艾沙多林 ,

It’s only fair to share… Eluxadoline Molecular FormulaC32H35N5O5 Average mass569.651 Da 5-({[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl][(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid 5-({[2-Amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid 864821-90-9 CAS JNJ-27018966 Molecular Formula: C32H35N5O5 Molecular Weight: 569.6508 Agents for Irritable Bowel Syndrome, mu-Opioid Agonists, delta-Opioid Antagonists Eluxadoline Trade Name: Viberzi® Research Code: JNJ-27018966, JNJ27018966, JNJ 27018966 Chemical Name: 5 – [[[(2S) -2-amino-3- [4- (aminocarbonyl) -2,6-dimethylphenyl ] -1- oxopropyl] [(1S) -1- (4-phenyl-1H-imidazol-2-yl) ethyl] amino] methyl] …

ROLAPITANT, ロラピタント

It’s only fair to share… ROLAPITANT HYDROCHLORIDE Rolapitant HCl Rolapitant hydrochloride Sch 619734 SCH619734 UNII-57O5S1QSAQ (5S ,8S)-8-[[(1R)-1-[3 ,5- Bis(trifluoromethyl)phenyl] ethoxy] methyl]-8-phenyl-1,7- diazaspiro[4.5]decan-2-one hydrochloride monohydrate. CAS 914462-92-3 Empirical Formula: C25H26F6N2O2 · HCl · H2O, Molecular Weight:  555 USAN Name: Rolapitant hydrochloride, INN Name:  rolapitantum or rolapitant CAS Number: 552292-08-7 (rolapitant free base); 914462-92-3 (rolapitant HCl monohydrdate). Rolapitant Molecular FormulaC25H26F6N2O2 Average mass500.477 Da (5S,8S)-8-({(1R)-1-[3,5-Bis(trifluorométhyl)phényl]éthoxy}méthyl)-8-phényl-1,7-diazaspiro[4.5]décan-2-one 1,7-Diazaspiro[4.5]decan-2-one, …

Selexipag, セレキシパグ ,селексипаг , سيليكسيباق ,

It’s only fair to share…     Selexipag Molecular FormulaC26H32N4O4S Average mass496.622 Da Selexipag, Uptravi 475086-01-2 CAS (C26H32N4O4S, Mr = 496.6 g/mol) A prostacyclin receptor (PGI2) agonist used to treat pulmonary arterial hypertension (PAH). NIPPON SHINYAKU….INNOVATOR セレキシパグ UNII-5EXC0E384L селексипаг [Russian] [INN] سيليكسيباق [Amharic] [INN] 2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}-N-(methylsulfonyl)acetamide 475086-01-2 [RN] 5EXC0E384L 9231 Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)- Selexipag (brand name Uptravi) is a drug developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). …