Category «Uncategorized»

Amcenestrant (SAR 439859)

It’s only fair to share… Amcenestrant  (SAR 439859) アムセネストラント Molecular Weight 554.48 Formula C31H30Cl2FNO3 CAS No. 2114339-57-8 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid Amcenestrant 8-(2,4-dichlorophenyl)-9-(4-{[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxy}phenyl)-6,7-dihydro – 5H- Benzo[7]annulene-3-carboxylic acid 8-(2,4-Dichlorophenyl)-9-(4-{[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxy}phenyl)-6,7-dihydro-5 H -benzo [7]annulene-3-carboxylic acid C31H30Cl2FNO3  : 554.48 [ 2114339-57-8 ] _ _ _ _ _ _   Efficacy Antineoplastic, Selective estrogen receptor downregulator Comment Selective estrogen receptor downregulator (SERD) Treatment of breast cancer   SAR439859 (compound 43d) is an orally active, nonsteroidal and selective estrogen receptor degrader …

SC-52458, FORASARTAN

It’s only fair to share… SC-52458, FORASARTAN Molecular FormulaC23H28N8 Average mass416.522 Da PHASE 2,  PFIZER, HYPERTENSION 145216-43-9 [RN] 5-[(3,5-Dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-yl)phenyl]pyridine 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]pyridine форасартан [Russian] [INN], فوراسارتان[Arabic][INN], 福拉沙坦[Chinese][INN] 065F7WPT0B [DBID] 7415 [DBID] UNII-065F7WPT0B [DBID] SC 52458 [DBID] Type-1 angiotensin II receptor Forasartan, otherwise known as the compound SC-52458, is a nonpeptide angiotensin II receptor antagonist (ARB, AT1 receptor blocker).[2][3][4][5] Forasartan, a specific angiotensin II antagonist, is used alone or with …

Adagrasib

It’s only fair to share… Adagrasib Formula C32H35ClFN7O2 cas  2326521-71-3 Mol weight 604.1174 Antineoplastic   Disease Non-small cell lung cancer 2022/12/12 FDA APPROVED, KRAZATI (Mirati Therapeutics) MRTX-849 MRTX849 KRAS G12C inhibitor MRTX849 Adagrasib, sold under the brand name Krazati, is an anticancer medication used to treat non-small cell lung cancer.[1][2] Adagrasib is an inhibitor of the RAS GTPase family.[1] It is taken by mouth.[1] It …

ABT-737

It’s only fair to share… ABT-737 Molecular Weight 813.43 Formula C42H45ClN6O5S2 CAS No. 852808-04-9 ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains. First developed as a potential cancer chemotherapy,[1] it was subsequently identified as a senolytic (a drug that selectively induces cell death in senescent cells).[2] The Bcl-2 family is most notable for their regulation of apoptosis, a form …

Tolebrutinib

It’s only fair to share… Tolebrutinib SAR442168 Treatment of Multiple Sclerosis (MS) CAS 1971920-73-6 PRN 2246, example 3 [WO2016196840A1] C26H25N5O3, 455.5 GTPL10625 BTK’168 EX-A4699 BDBM50557487 WHO 11268 4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one 4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one (R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one 4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-(prop-2- enoyl)piperidin-3-yl]-1,3-dihydro-2H-imidazo[4,5- 2H-Imidazo(4,5-C)pyridin-2-one, 4-amino-1,3-dihydro-1-((3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl)-3-(4-phenoxyphenyl)- 4-Amino-1,3-dihydro-1-((3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl)-3-(4-phenoxyphenyl)-2H-imidazo(4,5-C)pyridin-2-one Tolebrutinib (R&D code SAR442168), developed by Principia and later acquired by Sanofi and included in its product line, Tolebrutinib is a …

Relacorilant

It’s only fair to share… Relacorilant Molecular FormulaC27H22F4N6O3S Average mass586.561 Da CAS 1496510-51-0 Phase III UNII-2158753C7E 2158753C7E [(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone [(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone Methanone, [(4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)-2-pyridinyl]- Methanone, ((4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4ah-pyrazolo(3,4-g)isoquinolin-4a-yl)(4-(trifluoromethyl)-2-pyridinyl)- релакорилант [Russian] [INN] ريلاكوريلانت [Arabic] [INN] 瑞拉可兰 [Chinese] [INN] OriginatorCorcept Therapeutics ClassAntineoplastics; Fluorine compounds; Isoquinolines; Ketones; Organic sulfur compounds; Pyrazoles; Pyridines; Small molecules Mechanism of ActionGlucocorticoid receptor antagonists Orphan Drug StatusYes – Pancreatic cancer; Cushing syndrome Phase IIICushing syndrome; …

Milademetan

It’s only fair to share…   Milademetan Molecular Weight 618.53 Formula C30H34Cl2FN5O4 CAS No. 1398568-47-2   Milademetan. hcl Chemical Formula: C30H35Cl3FN5O4 Exact Mass: 617.1972 Molecular Weight: 654.99 Elemental Analysis: C, 55.01; H, 5.39; Cl, 16.24; F, 2.90; N, 10.69; O, 9.77 1398568-47-2 (free base)   1398569-75-9 (tosylate)   2095625-97-9 (tosylate hydrate)   Milademetan HCl  DS3032b; DS-3032b; DS 3032b; DS3032; …

Firibastat

It’s only fair to share… Firibastat Molecular FormulaC8H20N2O6S4 Average mass368.514 Da C8H20N2O6S4 368.5 RB 150 Qgc-001(racemate) UNII-PD5EII1F9A Firibastat, (+/-)- PD5EII1F9A 3-amino-4-[(2-amino-4-sulfobutyl)disulfanyl]butane-1-sulfonic acid (+/-)-QGC-001 1-Butanesulfonic acid, 4,4′-dithiobis(3-amino- 3-Amino-4-((2-amino-4-sulfo-butyl)disulfanyl)butane-1-sulfonic acid cas 721392-96-7, RACEMIC CAS 648927-86-0, (S)-3-amino-4-(((S)-2-amino-4-sulfobutyl)disulfaneyl)butane-1-sulfonic acid фирибастат [Russian] [INN] فيريباستات [Arabic] [INN] (3S,3’S)-4,4′-Disulfanediylbis(3-aminobutane-1-sulfonic acid) firibastatum фирибастат فيريباستات 非立巴司他 [Chinese] PAPER Journal of Labelled Compounds & Radiopharmaceuticals (2004), 47(13), 997-1005 PATENT https://patents.google.com/patent/WO2020084131A1/en PATENT WO2012045849 …

Ozoralizumab

It’s only fair to share…   Ozoralizumab Formula C1682H2608N472O538S12 CAS  1167985-17-2 Mol weight 38434.3245  PMDA JAPAN  APPROVED 2022 2022/9/26 Nanozora anti-TNFα Nanobody®; ATN-103; Nanozora; PF-5230896; TS-152 Ozoralizumab is a humanized monoclonal antibody designed for the treatment of inflammatory diseases.[1] Ozoralizumab was developed by Pfizer Inc, and now belongs to Ablynx NV. Ablynx has licensed the rights to the antibody in China to Eddingpharm. …

Futibatinib

It’s only fair to share… Futibatinib フチバチニブ Formula C22H22N6O3 CAS 1448169-71-8 Mol weight 418.4485 2022/9/30 FDA APPROVED, Lytgobi Antineoplastic, Receptor tyrosine kinase inhibitor   Disease Cholangiocarcinoma (FGFR2 gene fusion) 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one TAS-120, TAS 120, TAS120; Futibatinib Futibatinib, also known as TAS-120 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR …