Category «PHASE 3»

Piclidenoson, иклиденозон , بيكليدينوسون , 匹利诺生 ,

It’s only fair to share…   CF 101, Piclidenoson ALB-7208 CAS 152918-18-8 Chemical Formula: C18H19IN6O4 Molecular Weight: 510.28 (2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-N-methyltetrahydro-2-furancarboxamide N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide β-D-Ribofuranuronamide, 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl- 1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide 10136 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide 30679UMI0N UNII-30679UMI0N Пиклиденозон [Russian] [INN] بيكليدينوسون [Arabic] [INN] 匹利诺生 [Chinese] [INN] CF 101 (known generically as IB-MECA) is an anti-inflammatory drug for rheumatoid arthritis patients. Its novel mechanism of action relies on antagonism of adenoside A3 …

VX-445, Elexacaftor, エレクサカフトル

It’s only fair to share… VX-445, Elexacaftor, エレクサカフトル 597.658 g/mol, C26H34F3N7O4S 3-Pyridinecarboxamide, N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)- N-[(1,3-Dimethyl-1H-pyrazol-4-yl)sulfonyl]-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-3-pyridinecarboxamide 3-Pyridinecarboxamide, N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)- UNII-RRN67GMB0V RRN67GMB0V VX-445 WHO 11180 Cas 2216712-66-0 WHO 11180 Treatment of cystic fibrosis, CFTR modulator Elexacaftor is under investigation in clinical trial NCT03525548 (A Study of VX-445 Combination Therapy in CF Subjects Homozygous for F508del (F/F)). Cystic fibrosis transmembrane conductance regulator (CFTR) corrector …

MITAPIVAT

It’s only fair to share… MITAPIVAT CAS 1260075-17-9 MF C24H26N4O3S MW 450.55 8-Quinolinesulfonamide, N-[4-[[4-(cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]- N-[4-[[4-(Cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]-8-quinolinesulfonamide Originator Agios Pharmaceuticals Class Antianaemics; Piperazines; Quinolines; Small molecules; Sulfonamides Mechanism of Action Pyruvate kinase stimulants Orphan Drug Status Yes – Inborn error metabolic disorders New Molecular Entity Yes Phase III Inborn error metabolic disorders Phase II  Thalassaemia 27 Feb 2019 Agios Pharmaceuticals plans a phase III trial for …

RISDIPLAM , リスジプラム

It’s only fair to share… RISDIPLAM RG-7916, RO-7034067, リスジプラム Formula C22H23N7O Cas 1825352-65-5 Mol weight 401.4643 US9969754 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one   WHO 10614 RG-7916 HY-109101 RO7034067 CS-0039501 EX-A2074 RG7916 The compound was originally claimed in WO2015173181 , for treating spinal muscular atrophy (SMA). Roche , under license from PTC Therapeutics , and Chugai , are developing risdiplam (RO-7034067; RG-7916), …

FOSTEMSAVIR ,фостемсавир , فوستيمسافير  , 磷坦姆沙韦  ,ホステムサビル;

It’s only fair to share… FOSTEMSAVIR ,фостемсавир , فوستيمسافير  , 磷坦姆沙韦  ,ホステムサビル; Fostemsavir GSK3684934 CAS 864953-29-7 Molecular FormulaC25H26N7O8P Average mass583.490 Da ホステムサビル; [3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate {3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate [ACD/IUPAC Name] 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]- [ACD/Index Name] 10292 864953-29-7 [RN] фостемсавир [Russian] [INN] فوستيمسافير [Arabic] [INN] 磷坦姆沙韦 [Chinese] [INN] BMS 663068 BMS663068 Fostemsavir tromethamine UNII-2X513P36U0   Fostemsavir tromethamine [USAN], CAS 864953-39-9, MW 704.6303 Prodrug of BMS-626529, an HIV-1 attachment inhibitor. …

IMETELSTAT

It’s only fair to share…       IMETELSTAT CAS 868169-64-6, N163L Molecular Formula, C148-H211-N68-O53-P13-S13, Molecular Weight, 4610.2379, Nucleic Acid Sequence Sequence Length: 135 a 1 c 4 g 3 tmodified DNA d(3′-amino-3′-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A) 5′-[O-[2-hydroxy-3-[(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate] PHASE 3, GERON, Myelodysplasia IMETELSTAT SODIUM CAS 1007380-31-5, GRN163L, GRN 163L Sodium Salt Molecular Formula: C148H198N68Na13O53P13S13 Molecular Weight: 4895.941 g/mol 5′-(O-(2-hydroxy-3-((1-oxohexadecyl)amino)propyl)phosphorothioate)-d(3′-amino-3′-deoxy-p-thio)(t-a-g-g-g-t-t-a-g-a-c-a-a), sodium salt (13) …

Esaxerenone エサキセレノン , эсаксеренон , إيساكسيرينون , 艾沙利 酮 ,

It’s only fair to share… Esaxerenone エサキセレノン , эсаксеренон , إيساكسيرينون , 艾沙利  酮 ,  CS-3150, XL-550 Formula C22H21F3N2O4S CAS 1632006-28-0 Mol weight 466.4734 Pmda approved japan, 2019/1/8, Minebro Antihypertensive, Aldosterone antagonist N62TGJ04A1 UNII:N62TGJ04A1 эсаксеренон [Russian] [INN] إيساكسيرينون [Arabic] [INN] 艾沙利酮 [Chinese] [INN] 1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide 10230 1632006-28-0 [RN], 880780-76-7, 1072195-82-4 (+ isomer)   1072195-83-5 (- isomer) 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]- Originator X-Ceptor Therapeutics Developer Daiichi Sankyo Company Class Antihyperglycaemics; Antihypertensives; Pyrroles; Small molecules; Sulfones Mechanism of Action Mineralocorticoid receptor antagonists …

Relugolix レルゴリクス

It’s only fair to share…   Relugolix (TAK-385), RVT 601 レルゴリクス Formula C29H27F2N7O5S CAS 737789-87-6 Mol weight UNII 623.6304 UNII-P76B05O5V6 2019/1/8  PMDA JAPAN APPROVED, Relumina 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N’-methoxy-  737789-87-6 [RN] 9628 P76B05O5V6 Originator Takeda Developer Myovant Sciences; Takeda; Takeda Oncology Class Analgesics; Antineoplastics; Ketones; Pyrimidines; Small molecules Mechanism of Action LHRH receptor antagonists Preregistration Uterine leiomyoma Phase III Pain; Prostate cancer No development reported Solid …

Omecamtiv mecarbil オメカムティブメカビル

It’s only fair to share… Omecamtiv mecarbil Molecular FormulaC20H24FN5O3 Average mass401.435 Da 4-[2-fluoro-3-[(6-methyl-3-pyridyl)carbamoylamino]benzyl]piperazine-1-carboxylic acid methyl ester AMG 423 AMG-423 CK1827452 CK-1827452; CK1827452 Cladribine [BAN] [INN] [JAN] [USAN] [Wiki] methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester 2M19539ERK オメカムティブメカビル 873697-71-3 [RN] 9088 Methyl 4-(2-fluoro-3-{[(6-methyl-3-pyridinyl)carbamoyl]amino}benzyl)-1-piperazinecarboxylate NMR https://file.selleckchem.com/downloads/nmr/S262301-CK-1827452-NMR-Selleck.pdf In January 2019, Cytokinetics and licensees Amgen and Servier are developing oral modified- and immediate-release formulations of the cardiac …

SELETALISIB, селеталисиб , سيلستاليسيب , 司来利塞 ,

It’s only fair to share… SELETALISIB CAS 1362850-20-1 UCB-5857 , Plaque psoriasis,Sjoegren’s syndrome,Immunodeficiency disorders PHASE 3 UCB 23H14ClF3N6O , 482.85 Phosphatidylinositol 3 kinase delta (PI3Kδ) inhibitors 10023 1362850-20-1 [RN] N-{(1R)-1-[8-Chlor-2-(1-oxido-3-pyridinyl)-3-chinolinyl]-2,2,2-trifluorethyl}pyrido[3,2-d]pyrimidin-4-amine N—{(R)-1-[8-Chloro-2-(pyridin-3-yl)quinolin-3-yl]-2,2,2-trifluoroethyl}N-(1-oxypyrido-[3,2-d]pyrimidin-4-yl)amine Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]- 3-{8-chloro-3-[(1R)-2,2,2-trifluoro-1-({pyrido[3,2-d]pyrimidin-4-yl}amino)ethyl]quinolin-2-yl}pyridin-1-ium-1-olate селеталисиб [Russian] [INN] سيلستاليسيب [Arabic] [INN] 司来利塞 [Chinese] [INN] N-[(1R)-1-[8-chloro-2-(1-oxidopyridin-1-ium-3-yl)quinolin-3-yl]-2,2,2-trifluoroethyl]pyrido[3,2-d]pyrimidin-4-amine Seletalisib has been used in trials studying the treatment and basic science of Primary Sjogren’s Syndrome. Originator UCB Class Anti-inflammatories; Small molecules Mechanism …