Category «PHASE 3»

Azeliragon

It’s only fair to share… Azeliragon C32H38ClN3O2, 532.1 g/mol CAS 603148-36-3 TTP488 UNII-LPU25F15UQ LPU25F15UQ TTP-488; PF-04494700 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine MOA:RAGE inhibitor Indication:Alzheimer’s disease (AD) Status:Phase III (Active), Dementia, Alzheimer’s type Company:vTv Therapeutics (Originator) Azeliragon Azeliragon is in phase III clinical for the treatment of Alzheimer’s type dementia. Azeliragon was originally by TransTech Pharma (now vTv Therapeutics), then licensed to Pfizer in …

Benvitimod, Tapinarof, тапинароф , تابيناروف , 他匹那罗 ,

It’s only fair to share… Benvitimod, Tapinarof 3,5-dihydroxy-4-isopropyl-trans-stilbene Launched – 2019 CHINA, Psoriasis, Tianji Pharma тапинароф [Russian] [INN]WBI-1001 تابيناروف [Arabic] [INN] 他匹那罗 [Chinese] [INN] (E)-2-(1-Methylethyl)-5-(2-phenylethenyl)-1,3-benzenediol 1,3-Benzenediol, 2-(1-methylethyl)-5-(2-phenylethenyl)-, (E)- 1,3-Benzenediol, 2-(1-methylethyl)-5-[(E)-2-phenylethenyl]- 10253 2-Isopropyl-5-[(E)-2-phenylvinyl]-1,3-benzenediol 3,5-Dihydroxy-4-isopropyl-trans-stilbene 5-[(E)-2-phenylethenyl]-2-(propan-2-yl)benzene-1,3-diol 79338-84-4 [RN] 84HW7D0V04 Research Code:WB-1001; WBI-1001 Trade Name:MOA:NSAID Indication:Atopic dermatitis; PsoriasisStatus: Phase III (Active) Company:GlaxoSmithKline (Originator), Welichem Biotech (Originator), 天济药业 (Originator) 2894512 DMVT-505 GSK-2894512 RVT-505 WB-1001 WBI-1001 84HW7D0V04 (UNII code) In May 2019, the drug …

PF 04965842, Abrocitinib

It’s only fair to share…   PF-04965842 PF 04965842, Abrocitinib UNII: 73SM5SF3OR CAS Number 1622902-68-4, Empirical Formula  C14H21N5O2S, Molecular Weight 323.41 N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide, N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide 1-Propanesulfonamide, N-(cis-3-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)cyclobutyl)- N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide PHASE 3, for the potential oral treatment of moderate-to-severe atopic dermatitis (AD) Jak1 tyrosine kinase inhibitor THE US In February 2018, the FDA granted Breakthrough Therapy designation for the treatment of patients with moderate-to-severe …

Fasoracetam

It’s only fair to share… Fasoracetam Molecular FormulaC10H16N2O2 Average mass196.246 Da (5R)-5-(1-Piperidinylcarbonyl)-2-pyrrolidinone (5R)-5-(Piperidin-1-ylcarbonyl)pyrrolidin-2-one 110958-19-5 [RN] 2-Pyrrolidinone, 5-(1-piperidinylcarbonyl)-, (5R)- 7708, UNII: 42O8UF5CJB NS 105 N-(5-Oxo-D-prolyl)piperidine (+)-1-(((R)-5-Oxo-2-pyrrolidinyl)carbonyl)piperidine AEVI GENOMIC MEDICINE, INC. [US/US]; 435 Devon Park Drive, Suite 715 Wayne, Pennsylvania 19087, US Fasoracetam is a research chemical of the racetam family.[3] It is a putative nootropic that failed to show sufficient efficacy in clinical trials for vascular dementia. It is currently being …

Piclidenoson, иклиденозон , بيكليدينوسون , 匹利诺生 ,

It’s only fair to share…   CF 101, Piclidenoson ALB-7208 CAS 152918-18-8 Chemical Formula: C18H19IN6O4 Molecular Weight: 510.28 (2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-N-methyltetrahydro-2-furancarboxamide N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide β-D-Ribofuranuronamide, 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl- 1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide 10136 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide 30679UMI0N UNII-30679UMI0N Пиклиденозон [Russian] [INN] بيكليدينوسون [Arabic] [INN] 匹利诺生 [Chinese] [INN] CF 101 (known generically as IB-MECA) is an anti-inflammatory drug for rheumatoid arthritis patients. Its novel mechanism of action relies on antagonism of adenoside A3 …

VX-445, Elexacaftor, エレクサカフトル

It’s only fair to share… VX-445, Elexacaftor, エレクサカフトル 597.658 g/mol, C26H34F3N7O4S 3-Pyridinecarboxamide, N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)- N-[(1,3-Dimethyl-1H-pyrazol-4-yl)sulfonyl]-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-3-pyridinecarboxamide 3-Pyridinecarboxamide, N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)- UNII-RRN67GMB0V RRN67GMB0V VX-445 WHO 11180 Cas 2216712-66-0 WHO 11180 Treatment of cystic fibrosis, CFTR modulator Elexacaftor is under investigation in clinical trial NCT03525548 (A Study of VX-445 Combination Therapy in CF Subjects Homozygous for F508del (F/F)). Cystic fibrosis transmembrane conductance regulator (CFTR) corrector …

MITAPIVAT

It’s only fair to share… MITAPIVAT CAS 1260075-17-9 MF C24H26N4O3S MW 450.55 8-Quinolinesulfonamide, N-[4-[[4-(cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]- N-[4-[[4-(Cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]-8-quinolinesulfonamide Originator Agios Pharmaceuticals Class Antianaemics; Piperazines; Quinolines; Small molecules; Sulfonamides Mechanism of Action Pyruvate kinase stimulants Orphan Drug Status Yes – Inborn error metabolic disorders New Molecular Entity Yes Phase III Inborn error metabolic disorders Phase II  Thalassaemia 27 Feb 2019 Agios Pharmaceuticals plans a phase III trial for …

RISDIPLAM , リスジプラム

It’s only fair to share… RISDIPLAM RG-7916, RO-7034067, リスジプラム Formula C22H23N7O Cas 1825352-65-5 Mol weight 401.4643 US9969754 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one   WHO 10614 RG-7916 HY-109101 RO7034067 CS-0039501 EX-A2074 RG7916 The compound was originally claimed in WO2015173181 , for treating spinal muscular atrophy (SMA). Roche , under license from PTC Therapeutics , and Chugai , are developing risdiplam (RO-7034067; RG-7916), …

FOSTEMSAVIR ,фостемсавир , فوستيمسافير  , 磷坦姆沙韦  ,ホステムサビル;

It’s only fair to share… FOSTEMSAVIR ,фостемсавир , فوستيمسافير  , 磷坦姆沙韦  ,ホステムサビル; Fostemsavir GSK3684934 CAS 864953-29-7 Molecular FormulaC25H26N7O8P Average mass583.490 Da ホステムサビル; [3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate {3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate [ACD/IUPAC Name] 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]- [ACD/Index Name] 10292 864953-29-7 [RN] фостемсавир [Russian] [INN] فوستيمسافير [Arabic] [INN] 磷坦姆沙韦 [Chinese] [INN] BMS 663068 BMS663068 Fostemsavir tromethamine UNII-2X513P36U0   Fostemsavir tromethamine [USAN], CAS 864953-39-9, MW 704.6303 Prodrug of BMS-626529, an HIV-1 attachment inhibitor. …

IMETELSTAT

It’s only fair to share…       IMETELSTAT CAS 868169-64-6, N163L Molecular Formula, C148-H211-N68-O53-P13-S13, Molecular Weight, 4610.2379, Nucleic Acid Sequence Sequence Length: 135 a 1 c 4 g 3 tmodified DNA d(3′-amino-3′-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A) 5′-[O-[2-hydroxy-3-[(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate] PHASE 3, GERON, Myelodysplasia IMETELSTAT SODIUM CAS 1007380-31-5, GRN163L, GRN 163L Sodium Salt Molecular Formula: C148H198N68Na13O53P13S13 Molecular Weight: 4895.941 g/mol 5′-(O-(2-hydroxy-3-((1-oxohexadecyl)amino)propyl)phosphorothioate)-d(3′-amino-3′-deoxy-p-thio)(t-a-g-g-g-t-t-a-g-a-c-a-a), sodium salt (13) …