Category «APPROVALS 2022»

Olipudase alfa

It’s only fair to share…   HPLSPQGHPA RLHRIVPRLR DVFGWGNLTC PICKGLFTAI NLGLKKEPNV ARVGSVAIKL CNLLKIAPPA VCQSIVHLFE DDMVEVWRRS VLSPSEACGL LLGSTCGHWD IFSSWNISLP TVPKPPPKPP SPPAPGAPVS RILFLTDLHW DHDYLEGTDP DCADPLCCRR GSGLPPASRP GAGYWGEYSK CDLPLRTLES LLSGLGPAGP FDMVYWTGDI PAHDVWHQTR QDQLRALTTV TALVRKFLGP VPVYPAVGNH ESTPVNSFPP PFIEGNHSSR WLYEAMAKAW EPWLPAEALR TLRIGGFYAL SPYPGLRLIS LNMNFCSREN FWLLINSTDP AGQLQWLVGE LQAAEDRGDK VHIIGHIPPG HCLKSWSWNY YRIVARYENT LAAQFFGHTH VDEFEVFYDE ETLSRPLAVA FLAPSATTYI GLNPGYRVYQ IDGNYSGSSH VVLDHETYIL NLTQANIPGA IPHWQLLYRA RETYGLPNTL …

TOLVAPTAN

It’s only fair to share… TOLVAPTAN 的合成 N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide Formula C26H25ClN2O3  Mol. mass 448.941 g/mol 150683-30-0 CAS NO + form  331947-66-1 Rform OPC-41061 Otsuka…..innovator   UPDATE 2022 Tolvaptan sodium phosphate, Samtasu, トルバプタンリン酸エステルナトリウム 2022/3/28 JAPAN PPROVED Formula C26H24ClN2O6P. 2Na CAS Mol weight 572.8849 Tolvaptan sodium phosphate disodium;[(5R)-7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1-benzazepin-5-yl] phosphate European Medicines Agency (EMA) Accepts Otsuka’s Marketing Authorisation Application …

Andexanet alfa

It’s only fair to share…   (heavy chain) IVGGQECKDG ECPWQALLIN EENEGFCGGT ILSEFYILTA AHCLYQAKRF KVRVGDRNTE QEEGGEAVHE VEVVIKHNRF TKETYDFDIA VLRLKTPITF RMNVAPACLP ERDWAESTLM TQKTGIVSGF GRTHEKGRQS TRLKMLEVPY VDRNSCKLSS SFIITQNMFC AGYDTKQEDA CQGDAGGPHV TRFKDTYFVT GIVSWGEGCA RKGKYGIYTK VTAFLKWIDR SMKTRGLPKA KSHAPEVITS SPLK (light chan) ANSFLFWNKY KDGDQCETSP CQNQGKCKDG LGEYTCTCLE GFEGKNCELF TRKLCSLDNG DCDQFCHEEQ NSVVCSCARG YTLADNGKAC IPTGPYPCGK QTLER (Disulfide bridge: H7-H12, H27-H43, H108-L98, H156-H170, H181-H209, L16-L27, …

Ferric derisomaltose

It’s only fair to share… Ferric derisomaltose WeightAverage: 562.297 Monoisotopic: 562.117975Chemical FormulaC18H34FeO16 Monover, JAPAN 2022, 2022/3/28 Monoferric (TN); Monover (TN) Anti-anemic, Hematinic, Supplement (iron) CAS 1345510-43-1 デルイソマルトース第二鉄 NS32 WHO 9712 UNII-AHU547PI9H Originator Company Pharmacosmos Active Companies Nippon Shinyaku Co Ltd; Pharmacosmos A/S; Wasserburger Arzneimittelwerk Gmbh; Zealand University Hospital iron(3+) (2S,3R,4R,5R)-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}hexane-1,2,3,4,5-pentol alpha-D-Glucan, (1-6)-, reduced, reaction products with iron …

Carotegrast methyl

It’s only fair to share… Carotegrast methyl Formula C28H26Cl2N4O5 CAS 401905-67-7 Mol weight 569.4358 PMDA APROVED, CAROGRA, カロテグラストメチル ON 2022/3/28 Antiasthmatic, Integrin alpha 4 inhibitor An alpha4 integrin antagonist. 401905-67-7 [RN] L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[6-(dimethylamino)-1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl]-, methyl ester methyl (2S)-2-[(2,6-dichlorophenyl)formamido]-3-{4-[6-(dimethylamino)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl]phenyl}propanoate Methyl N-(2,6-dichlorobenzoyl)-4-[6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]-L-phenylalaninate Carotegrast Methyl Methyl (2S)-2-(2,6-dichlorobenzamido)-3-{4-[6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]phenyl}propanoate C28H26Cl2N4O5 : 569.44 [401905-67-7] PATENT WO 2008062859 https://patents.google.com/patent/WO2008062859A1/en       Step 1 (Method 2): The title compound …

Risperidone

It’s only fair to share… Risperidone EU APPROVED 2022/2/14, Okedi   R-64,766 R-64766 RCN-3028 RCN3028 Risperidone, R-64766, Risperdal M-Tab, Risperdal Consta, Rispolept, Belivon, Risperdal Formula C23H27FN4O2 CAS 106266-06-2 Mol weight 410.4845 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one Product Ingredients INGREDIENT UNII CAS INCHI KEY Risperidone tartrate 0S6B72E3LK 666179-92-6 KSWIOGDSXUFKOC-LREBCSMRSA-N Risperidone CAS Registry Number: 106266-06-2 CAS Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Manufacturers’ Codes: R-64766 Trademarks: Belivon (Organon); Risperdal (J & …

Lutetium Lu 177 vipivotide tetraxetan

It’s only fair to share… Lutetium Lu 177 vipivotide tetraxetan FDA APPROVED 2022/3/23, Pluvicto To treat prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer following other therapies Formula C49H65N9O16. Lu. 3H CAS 1703749-62-5 Mol weight 1214.0819 Antineoplastic, Radioactive agent   Disease Prostate cancer (PSMA positive) ルテチウム(177Lu)ビピボチドテトラキセタン; UNII-G6UF363ECX, WHO 11429 G6UF363ECX 177Lu-Psma-617 Vipivotide tetraxetan Lu-177 177Lu-Labeled PSMA-617 2-[4-[2-[[4-[[(2S)-1-[[(5S)-5-carboxy-5-[[(1S)-1,3-dicarboxypropyl]carbamoylamino]pentyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamoyl]cyclohexyl]methylamino]-2-oxoethyl]-7,10-bis(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;lutetium-177(3+) (177Lu)Lutetium 2,2′,2′‘-[10-(2-{[(trans-4-{[(2S)-1-{[(5S)-5-carboxy-5-({[(1S)-1,3-dicarboxypropyl]carbamoyl}amino)pentyl]amino}-3-(2-naphthyl)-1-oxo-2-propanyl]carbamoyl}cyclohexyl)methyl]amino}-2- oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl]triacetate …

Ganaxolone

It’s only fair to share… Ganaxolone Molecular FormulaC22H36O2 Average mass332.520 Da (3a,5a)-3-Hydroxy-3-methylpregnan-20-one (3α,5α)-3-Hydroxy-3-methylpregnan-20-one 38398-32-2 [RN] 3α-hydroxy-3β-methyl-5α-pregnan-20-one 7476 CCD-1042 FDA APPROVED 3/18/2022, Ztalmy To treat seizures in cyclin-dependent kinase-like 5 deficiency disorder Ganaxolone, sold under the brand name Ztalmy, is a medication used to treat seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD).[1][2] Ganaxolone was approved for medical use in …

Ciltacabtagene autoleucel

It’s only fair to share… Ciltacabtagene autoleucel FDA APPROVED, 2022/2/28,  Carvykti   Treatment of multiple myeloma   JNJ-68284528 LCAR-B38M CAR-T cells   Ciltacabtagene autoleucel is a BCMA-directed CAR T-cell therapy used in the treatment of relapsed or refractory multiple myeloma in previously treated patients. U.S. FDA Approves CARVYKTI™ (ciltacabtagene autoleucel), Janssen’s First Cell Therapy, a BCMA-Directed CAR-T …

PACRITINIB

It’s only fair to share…   Pacritinib パクリチニブ; Formula C28H32N4O3 CAS 937272-79-2 Mol weight 472.5787 UPDATE  FDA APPROVED  2/28/2022, Vonjo To treat intermediate or high-risk primary or secondary myelofibrosis in adults with low platelets A Jak2 inhibitor potentially for the treatment of acute myeloid Leukemia and myelofibrosis. UNII-G22N65IL3O пакритиниб باكريتينيب 帕瑞替尼 ONX-0803; SB-1518 CAS No. …