Category «Phase 2»

It’s only fair to share… CAS 2254433-37-7 CAS 2254432-75-0 High probabilty ZYIL 1 TWO PREDICTIONS Cryopyrin-associated periodic syndromes ZYIL-1 is an oral, small-molecule inhibitor of the NLRP3 inflammasome in phase II clinical development at Zydus (formerly known as Cadila Healthcare and Zydus Cadila) for the treatment of cryopyrin-associated periodic syndromes (familial cold autoinflammatory syndrome (FCAS), Muckle-Wells …

Read more

It’s only fair to share… Camizestrant, AZD 9833 AZ 14066724 PHASE 2 CAS: 2222844-89-3 Chemical Formula: C24H28F4N6 Exact Mass: 476.2312 Molecular Weight: 476.5236 Elemental Analysis: C, 60.49; H, 5.92; F, 15.95; N, 17.64  N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine   AZ14066724 AZD-9833 AZD9833 Camizestrant UNII-JUP57A8EPZ WHO 11592   OriginatorAstraZeneca ClassAmines; Antineoplastics; Azetidines; Fluorinated hydrocarbons; Isoquinolines; Pyrazolones; Pyridines; Small molecules Mechanism …

Read more

It’s only fair to share… ARIMOCLOMOL アリモクロモル; Formula C14H20ClN3O3 Exact mass 313.1193 Mol weight 313.7799 CAS 289893-25-0 289893-26-1 (Arimoclomol maleate); INN 8300 N-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy]-1-oxidopyridin-1-ium-3-carboximidoyl chloride BRX 220 Arimoclomol maleate is in a phase III clinical trials by Orphazyme for the treatment of Niemann-Pick disease type C (NP-C). It is also in phase II clinical studies for the …

Read more

It’s only fair to share… Rabeximod, ROB 803 C22H24ClN5O,  409.92 2-(9-chloro-2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-N-[2-(dimethylamino)ethyl]acetamide CAS 872178-65-9 UNII-J4D3K58W3Z, рабексимод , رابيكسيمود 雷贝莫德 6H-Indolo[2,3-b]quinoxaline-6-acetamide, 9-chloro-N-[2-(dimethylamino)ethyl]-2,3-dimethyl- 872178-65-9 [RN] 8866, J4D3K58W3Z OriginatorOxyPharma DeveloperCyxone; University of California ClassAcetamides; Anti-inflammatories; Disease-modifying antirheumatics; Heterocyclic compounds with 4 or more rings; Small molecules Mechanism of ActionCell differentiation modulators; Macrophage inhibitors Phase IICOVID 2019 infections; Rheumatoid arthritis 12 Oct 2021Cyxone terminates a phase-II trial …

Read more

It’s only fair to share… (2S,3R)-2-(3-((S)-3-amino-1-(3-((R)-1-amino-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)-3-oxopropyl)ureido)-3-hydroxybutanoic acid Molecular Weight (MW)  360.33 Formula  C12H20N6O7 CAS No.  1673534-76-3 N-[[[(1S)-3-Amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]amino]carbonyl]-L-threonine L-Threonine, N-[[[(1S)-3-amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]amino]carbonyl]-  AUPM 170, CA 170, AUPM-170, CA-170, PD-1-IN-1 Novel inhibitor of programmed cell dealth-1 (PD-1) CA-170 (also known as AUPM170 or PD-1-IN-1) is a first-in-class, potent and orally available small molecule inhibitor of the immune checkpoint regulatory proteins PD-L1 …

Read more

It’s only fair to share… AUR 101 AUR101-201 ANTIINNFLAMATORY AUR-101, a ROR gamma inverse agonist for autoimmune disorders like psoriasis AUR-101 is an ROR-gammaT inverse agonist in phase II clinical development at Aurigene for the treatment of patients with moderate-to-severe chronic plaque-type psoriasis. DrugsAUR 101 (Primary) IndicationsPlaque psoriasis FocusAdverse reactions; First in man AcronymsINDUS SponsorsAurigene Discovery …

Read more

It’s only fair to share…   Pralnacasan VX 740 cas 192755-52-5 (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide N-[(4S,7S)-4-{[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]carbamoyl}-6,10-dioxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-yl]isoquinoline-1-carboxamide (1S,9S)-N-((2R,3S)-2-Ethoxy-5-oxotetrahydrofuran-3-yl)-9-((isoquinolin-1-ylcarbonyl)amino)-6,10-dioxooctahydro-6-H-pyridazino(1,2-a)(1,2)diazepine-1-carboxamide 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxamide, N-((2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl)octahydro-9-((1-isoquinolinylcarbonyl)amino)-6,10-dioxo-, (1S,9S)- HMR 3480 HMR3480 HMR3480/VX-740 Pralnacasan UNII-N986NI319S VX 470 VX-740 C26H29N5O7, 523.543 NSAID, ICE inhibitor & metastasis inhibitor. пралнаказан [Russian] [INN] برالناكاسان [Arabic] [INN] 普那卡生 [Chinese] [INN] Pralnacasan is an orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE). Pralnacasan is …

Read more

It’s only fair to share… VX 148 297730-05-3 Name: VX-148 CAS#: 297730-05-3 Chemical Formula: C23H25N5O4 Exact Mass: 435.19065 Molecular Weight: 435.48 Elemental Analysis: C, 63.44; H, 5.79; N, 16.08; O, 14.70 Molecular Weight 435.48 Formula C23H25N5O4 CAS No. 297730-05-3 (VX 148); Chemical Name Carbamic acid, N-[(1S)-1-[3-[[[(4-cyano-3-methoxyphenyl)amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester MOA：Inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitorIndication：PsoriasisStatus：Phase Ⅱ (Discontinued)Company：Vertex (Originator) …

Read more

It’s only fair to share… VX- ? CAS  2446817-72-5 HYDRATE 2446818-26-2 Acetic acid, 1-methylethyl ester 2446818-27-3 C21 H20 F N3 O3, 381.4 1H-Indole-3-propanamide, 2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]- 3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).   PATENT WO/2021/158666 SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME Compound I is disclosed as Compound 87 …

Read more

It’s only fair to share… ONO-2910 CAS 2410177-35-2 3- [2-[(E) -5- [3- (benzenesulfonamide) phenyl] penta-4-enoxy] phenyl] propanoic acid 3- [2-[(E) -5- [3- (benzenesulfonamido) phenyl] penta-4-enoxy] phenyl] propanoic acid C26 H27 N O5 S 465.56 Benzenepropanoic acid, 2-[[(4E)-5-[3-[(phenylsulfonyl)amino]phenyl]-4-penten-1-yl]oxy]- ONO Pharmaceuticals is developing ONO-2910 , the lead from a program of novel transient receptor potential cation channel 4/5 inhibitors, for treating …

Read more