It’s only fair to share… SOVESUDIL PHP-201; AMA 0076, C23O3R93BM CAS 1333400-14-8 Molecular Weight 407.44 Formula C23H22FN3O3 Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia. SCHEME PATENTS Bioorganic & Medicinal Chemistry Letters (2013), 23(23), …
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Contezolid
It’s only fair to share… Contezolid WeightAverage: 408.337Monoisotopic: 408.104539468 Chemical FormulaC18H15F3N4O4 Shanghai MicuRx Pharmaceutical Co. Ltd Contezolid was approved for use by the National Medical Products Administration (NMPA) of China in 2021 Contezolid (trade name Youxitai) is an antibiotic of the oxazolidinone class.[1][2] It is effective against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, Streptococcus agalactiae, and other bacteria.[3] In 2021, it was approved by the National Medical …
AZVUDINE
It’s only fair to share… CAS 1011529-10-4 WeightAverage: 286.223Monoisotopic: 286.082581021 Chemical FormulaC9H11FN6O4 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one Azvudine is an antiviral drug which acts as a reverse transcriptase inhibitor.[3] It was discovered for the treatment of hepatitis C[4] and has since been investigated for use against other viral diseases such as AIDS and COVID-19,[2][5] for which it was granted conditional approval in China.[6][7] Azvudine was first discovered in 2007.[8] It costs …
Sontigidomide
It’s only fair to share… Sontigidomide CAS 2560577-69-5 Molecular Weight 513.47 Formula C26H22F3N3O5 N-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α-oxo-4-[1-(trifluoromethyl)cyclopropyl]benzeneacetamide enzeneacetamide, N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α-oxo-4-[1-(trifluoromethyl)cyclopropyl]- FDD2NVW84X, Sontigidomida Sontigidomide (Compound 5) is an antineoplastic compound. Sontigidomide inhibits MOLM-13 cell proliferation more than 80% at 1 μM (3 days). SCHEME COUPLER…………. MAIN………. PATENTS WO2023070120 BioTheryX, Inc. PATENT US20200369679 https://patentscope.wipo.int/search/en/detail.jsf?docId=US311579044&_cid=P20-MD87Y5-18242-1 Example 5 Compound I-5: N-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2-oxo-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide Compound I-5 …
Keverprazan
It’s only fair to share… 432.5 g/mol 1-[5-(2-fluorophenyl)-1-[3-(3-methoxypropoxy)phenyl]sulfonylpyrrol-3-yl]-N-methylmethanamine C22H25FN2O4S CAS 2209911-80-6 Molecular Weight 468.97 Formula C22H26ClFN2O4S Jiangsu Carephar Pharmaceuticals, isa potassium ion competitive acidblocker (P-CAB) that was approved inFebruary2023inChina for thetreatment of refluxesophagitis or duodenal ulcer inadults P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride …
BEXAGLIFLOZIN
It’s only fair to share… BexagliflozinTHR1442; THR-1442, EGT 0001442; EGT1442CAS :1118567-05-7(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[2- (cyclopropyloxy) ethoxy] phenyl} methyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H- pyran-3,4,5-triol D-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1S)- (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1-[4-Chloro-3-[4-[2-(cyclopropyloxy)ethoxy]benzyl]phenyl]-1-deoxy-beta-D-glucopyranose1,5-Anhydro-1(S)-[4-chloro-3-[4-[2-(cyclopropyloxy)ethoxy]benzyl]phenyl]-D-glucitol (1S)-1,5-anhydro-1-C-[4-chloro-3-({4-[2- (cyclopropyloxy)ethoxy]phenyl}methyl)phenyl]-D-glucitol Chemical Formula: C24H29ClO7Exact Mass: 464.16018 Mechanism of Action:SGLT2 inhibitor, Sodium-glucose transporter 2 inhibitorsIndication:Type 2 diabetes FDA APPROVED 1/20/2023 Brenzavvy To improve glycemic control in adults with type 2 diabetes mellitus as an …
Risevistinel
It’s only fair to share… Risevistinel NYX-783 CAS 2591344-26-0, UNII-52TU5MZG22 NYX 2925, 2012536-16-0, X062KF5ZV3 C14H23N3O4, 297.35 UNII-52TU5MZG22, X062KF5ZV3 (αS,4R)-α-[(1R)-1-Hydroxyethyl]-5-(2-methyl-1-oxopropyl)-1-oxo-2,5-diazaspiro[3.4]octane-2-acetamide 2,5-Diazaspiro[3.4]octane-2-acetamide, α-[(1R)-1-hydroxyethyl]-5-(2-methyl-1-oxopropyl)-1-oxo-, (αS,4S)- (2S,3R)-3-hydroxy-2-[(4S)-5-(2-methylpropanoyl)-3-oxo-2,5-diazaspiro[3.4]octan-2-yl]butanamide Risevistinel (NYX-783) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer’s disease, Parkinson’s …
Rezatapopt
It’s only fair to share… Rezatapopt, PC 14586 CAS 2636846-41-6 Molecular Weight 545.57 Synonyms PC14586 Formula C28H31F4N5O2 CAS No. 2636846-41-6 4-[3-[4-[[(3S,4R)-3-fluoro-1-methylpiperidin-4-yl]amino]-1-(2,2,2-trifluoroethyl)indol-2-yl]prop-2-ynylamino]-3-methoxy-N-methylbenzamide 5W59S33KC9 Rezatapopt (PC14586) is an orally active antineoplastic agent. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure. Rezatapopt …
Resigratinib
It’s only fair to share… Resigratinib, KIN 3248 CAS 2750709-91-0 C26H27F2N7O3 523.5 g/mol 3-[2-(1-cyclopropyl-4,6-difluorobenzimidazol-5-yl)ethynyl]-1-[(3S,5R)-5-(methoxymethyl)-1-prop-2-enoylpyrrolidin-3-yl]-5-(methylamino)pyrazole-4-carboxamide Resigratinib (KIN-3248) is an experimental anticancer medication which acts as a fibroblast growth factor receptor inhibitor (FGFRi) and is in early stage human clinical trials.[1][2][3] KIN-3248 is a small molecule that targets and inhibits oncogenic fibroblast growth factor receptors (FGFRs). It was designed to mainly target FGFR2 and …
Sebetralstat
It’s only fair to share… Sebetralstat, KVD 900 CAS 1933514-13-6 491.5 g/mol O5ZD2TU2B7 FDA 7/3/2025, Ekterly, To treat acute attacks of hereditary angioedema N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxopyridin-1-yl)methyl]phenyl]methyl]pyrazole-4-carboxamide Sebetralstat, sold under the brand name Ekterly, is a medication used for the treatment of hereditary angioedema.[1] Sebetralstat is a plasma kallikrein inhibitor.[1] Sebetralstat was approved for medical use in the United States in July 2025.[1][2] SYN https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00921 aReagents …