It’s only fair to share… Zevotrelvir, EDP 235 cas 2773516-53-1 N-[(2S)-1-[(2′S,3R)-2′-cyano-2-oxospiro[1H-indole-3,4′-pyrrolidine]-1′-yl]-4-methyl-1-oxopentan-2-yl]-4,6,7-trifluoro-N-methyl-1H-indole-2-carboxamide C28H26F3N5O3, 537.5 4U32ECV8B7 1H-Indole-2-carboxamide, N-[(1S)-1-[[(3R,5’S)-5′-cyano-1,2-dihydro-2-oxospiro[3H-indole-3,3′-pyrrolidin]-1′-yl]carbonyl]-3-methylbutyl]-4,6,7-trifluoro-N-methyl- Zevotrelvir (Compound 52) is a coronavirus inhibitor with IC50 ranges of <0.1 μM and <0.1mM for 229E hCoV and SARS-CoV-23C-like (3CL) proteases, respectively. Zevotrelvir has the potential to study viral infections. Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses. The genomic RNA of CoVs has a 5′-cap structure and …
Category «Uncategorized»
Afimetoran
It’s only fair to share… Afimetoran BMS-986256, WHO 11516 cas 2171019-55-7 2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]acetamide 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)acetamide C26H32N6O,444.583, phase 1 Afimetoran is an immunomodulator and an antagonist of toll-like receptors 7 and 8.1,2 It is also is under investigation in clinical trial NCT04269356 (Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986256 in Healthy Male …
Cefepime
It’s only fair to share… Cefepime 88040-23-7 INGREDIENT UNII CAS INCHI KEY Cefepime hydrochloride I8X1O0607P 123171-59-5 LRAJHPGSGBRUJN-OMIVUECESA-N Cefepime CAS Registry Number: 88040-23-7 CAS Name: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium inner salt Additional Names: 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium hydroxide inner salt 72-(Z)-2-(O-methyloxime); 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate Manufacturers’ Codes: BMY-28142 Molecular Formula: C19H24N6O5S2 Molecular Weight: 480.56 Percent Composition: C 47.49%, H 5.03%, N 17.49%, O 16.65%, S 13.34% Literature References: Semisynthetic, fourth generation cephalosporin …
Ceftobiprole
It’s only fair to share… C20H22N8O6S2 534.57 209467-52-7 (6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(N-hydroxyimino)acetamido]-8-oxo-3-{[(3E,3’R)-2-oxo-[1,3′-bipyrrolidin]-3-ylidene]methyl}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid BAL-9141 BAL-9141-000 BAL-9141000 BAL9141-000 RO 63-9141 RO-63-9141 RO-639141 ceftobiprole medocaril sodium Ro-655788 BAL-5788-001 Molecular Weight 712.64 Formula C26H25N8NaO11S2 CAS No. 252188-71-9 Appearance Solid Color Off-white to light yellow SMILES O=C(C(N(C1=O)[C@@](SC2)([H])[C@@H]1NC(/C(C3=NSC(N)=N3)=N\O)=O)=C2/C=C(CCN4[C@@](CC5)([H])CN5C(OCC(OC6=O)=C(O6)C)=O)/C4=O)O[Na] fda approved 4/3/2024, To treat certain bloodstream infections, bacterial skin and associated tissue infections, and community-acquired bacterial …
INAXAPLIN
It’s only fair to share… INAXAPLIN, 2446816-88-0 2446816-88-0 S2SJ2RVZ6Y UNII-S2SJ2RVZ6Y C21H18F3N3O3 3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl]propanamide Inaxaplin (VX-147) is a small-molecule apolipoprotein L1 inhibitor developed by Vertex Pharmaceuticals for APOL1-mediated kidney disease. In preliminary studies the drug has shown promise in treating people with kidney disease and multiple gain of function mutations on the APOL1 gene.[1][2] FSGS is a disease of the …
Golcadomide (CC-99282)
It’s only fair to share… Golcadomide (CC-99282) Molecular Weight 535.57 Formula C28H30FN5O5 CAS No. 2379572-34-4 (S)-2-(2,6-Dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione 2-[(3S)-2,6-Dioxo-3-piperidinyl]-4-[[[2-fluoro-4-[[3-(4-morpholinyl)-1-azetidinyl]methyl]phenyl]methyl]amino]-1H-isoindole-1,3(2H)-dione (ACI) (S)-2-(2,6-Dioxopiperidin-3-yl)-4-[[2-fluoro-4-[(3-morpholinoazetidin-1-yl)methyl]benzyl]amino]isoindoline-1,3-dione CC 1007548 CC 99282 CC-99282 CC1007548 Golcadomide WHO 12305 Golcadomide HCl, 2639939-36-7 Chemical Name: CC-99282 Hydrochloride; 2-[(3S)-2,6-Dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione hydrochloride Novel potent and orally active cereblon (CRBN) E3 ligase modulator Ref: https://www.sciencedirect.com/science/article/abs/pii/S0268960X22000686 Golcadomide is a modulator of the …
Igermetostat
It’s only fair to share… Igermetostat C32H46N4O4. 550.73 2409538-60-7 2KES6YSH8D INN 12655 BENZAMIDE, N-((1,2-DIHYDRO-4,6-DIMETHYL-2-OXO-3-PYRIDINYL)METHYL)-3-(ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO)-2-METHYL-5-((TRANS-3-(1-PIPERIDINYL)CYCLOBUTYL)OXY)-IGERMETOSTATIGERMETOSTAT [INN]N-((1,2-DIHYDRO-4,6-DIMETHYL-2-OXO-3-PYRIDINYL)METHYL)-3-(ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO)-2-METHYL-5-((TRANS-3-(1-PIPERIDINYL)CYCLOBUTYL)OXY)BENZAMIDEN-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-(ETHYL(OXAN-4-YL)AMINO)-2-METHYL-5-(((1R,3R)-3-(PIPERIDIN-1-YL)CYCLOBUTYL)OXY)BENZAMIDE IGERMETOSTAT is a small molecule drug with a maximum clinical trial phase of II and has 1 investigational indication. SCHEME PATENT https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020020374&_cid=P22-LR1SQG-34075-1 PATENT US20230382898 https://patentscope.wipo.int/search/en/detail.jsf?docId=US415363922&_cid=P22-LR1S46-25135-1 The compound has been disclosed in patent WO2020020374A1. It is an enhancer of Zeste …
Obeldesivir
It’s only fair to share… Obeldesivir, 2647441-36-7 361.35 g/mol C16H19N5O5 [(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methyl 2-methylpropanoate Q55KCM7PXB; ATV006; UNII-Q55KCM7PXB Scheme NEW A END OF PAGE CHECK Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient treatment of COVID-19 in high risk patients.[1][2] The purpose of the isobutyric ester modification on obeldesivir is to improve the oral bioavailability of the parent nucleoside, GS-441524. …
Oditrasertib
It’s only fair to share… Oditrasertib SAR443820; DNL788 Molecular Formula C14H15F2N3O2 Molecular Weight 295.2846 UNII-I1YQT8HC89 I1YQT8HC89 cas 2252271-93-3 4-(3,3-Difluoro-2,2-dimethylpropanoyl)-3,5-dihydro-2H-pyrido(3,4-F)(1,4)oxazepine-9-carbonitrile PYRIDO(3,4-F)-1,4-OXAZEPINE-9-CARBONITRILE, 4-(3,3-DIFLUORO-2,2-DIMETHYL-1-OXOPROPYL)-2,3,4,5-TETRAHYDRO- Oditrasertib is a serine/threonine kinase (STK) inhibitor. Oditrasertib (SAR443820) is an orally active, BBB-penetrable and selective reversible inhibitor of RIPK1. Oditrasertib can be used in the research of chronic inflammatory central nervous system diseases, such …
ORZILOBEN
It’s only fair to share… ORZILOBEN, CAS 1555822-28-0 2-methyl-3-(pentyloxy)benzoic acid Molecular Weight 222.28 Formula C13H18O3 Orziloben is a medium chain fatty acid (MCFA) analogue[1]. OriginatorPronova BioPharma DeveloperNorthSea Therapeutics ClassAntifibrotics; Hepatoprotectants; Omega 3 fatty acids; Unsaturated fatty acids Mechanism of ActionUndefined mechanism 28 Jan 2025No recent reports of development identified for phase-I development in Liver-disorders(In volunteers) …