Category «Uncategorized»

Gepotidacin

Gepotidacin CAS 1075236-89-3 GSK-2140944GSK2140944 WeightAverage: 448.527Monoisotopic: 448.222288786 Chemical FormulaC24H28N6O3(3R)-3-({4-[({2H,3H,4H-pyrano[2,3-c]pyridin-6-yl}methyl)amino]piperidin-1-yl}methyl)-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione FDA APPROVED 3/25/2025,Blujepa, To treat uncomplicated urinary tract infections Ingredient UNII CAS InChI Key Gepotidacin hydrochloride 30Z5B7ACV6 1075235-46-9 DPAHPKBTWARMFG-FSRHSHDFSA-N Gepotidacin mesylate 5P7X0H2O6B 1624306-20-2 MTLHHQWYERWLIX-RGFWRHHQSA-N Gepotidacin, sold under the brand name Blujepa, is an antibiotic medication used for the treatment of urinary tract infection.[1] Gepotidacin is a triazaacenaphthylene bacterial type II topoisomerase inhibitor.[1][2] It …

Vimseltinib

Vimseltinib 1628606-05-2 DCC-3014 2/14/2025 FDA APPROVED, Romvimza 3-methyl-5-[6-methyl-5-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxypyridin-2-yl]-2-(propan-2-ylamino)pyrimidin-4-one C23H25N7O2, 431.5 To treat symptomatic tenosynovial giant cell tumor for which surgical resection will potentially cause worsening functional limitation or severe morbidity Vimseltinib is an orally bioavailable inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and …

TREOSULFAN

TREOSULFAN C6H14O8S2 MW 278.29 FDA APPROVED 1/21/2025 Grafapex CAS 299-75-2 Treosulfan299-75-2TreosulphanOvastatTreosulfano NSC-39069 [(2S,3S)-2,3-dihydroxy-4-methylsulfonyloxybutyl] methanesulfonate Trecondi, Treosulfan was authorized for medical use in the European Union in June 2019 For use in combination with fludarabine as a preparative regimen for allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome Treosulfan, sold under the …

Bevemipretide

Bevemipretide, CAS 2356106-71-1 FREE BASE CAS SBT-272 Trihydrochloride, 2589640-11-7 607.7 g/mol, C31H45N9O4 F553HAL9V8 Phase IAmyotrophic lateral sclerosis 18 Sep 2024Pharmacodynamics data from a preclinical trial in dry age related macular degenration released by Stealth BioTherapeutics The present technology relates generally to compounds (i.e. peptidomimetics), compositions (e.g. medicaments) and methods for treating, preventing, inhibiting, amelioration or delaying …

Suzetrigine

Suzetrigine CAS 2649467-58-1 WeightAverage: 473.4Monoisotopic: 473.137396951Chemical FormulaC21H20F5N3O4 FDA 1/30/2025, Journavx To treat moderate to severe acute painPress Release Suzetrigine, sold under the brand name Journavx, is a medication used for the management of pain.[1][2] It is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous system,[3][4] avoiding the addictive potential of opioids. Suzetrigine is taken by mouth.[1] The most common adverse reactions include …

BENZGALANTAMINE

BENZGALANTAMINE CAS 224169-27-1 Benzgalantamine gluconate, 1542321-58-3 6h-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, benzoate (ester), (4as,6r,8as)- Formula C24H25NO4 Molar mass 391.467 g·mol−1 External IDs GLN-1062 gluconate UNIILN7PMJ4P57 CAS Number1542321-58-3 WeightAverage: 587.622Monoisotopic: 587.236661015 Chemical FormulaC30H37NO11 Benzgalantamine, sold under the brand name Zunveyl, is a medication used for the treatment of mild to moderate dementia of the Alzheimer’s type.[1] It is a cholinesterase inhibitor.[1] Benzgalantamine is a prodrug of galantamine.[1] The most common …

Tisolagiline

Tisolagiline CAS 1894207-44-3 PCH79KLX33 (2S)-2-[[4-[4-(trifluoromethyl)phenyl]phenyl]methylamino]propanamide 322.32 g/mol SCHEME Tisolagiline (INNTooltip International Nonproprietary Name; developmental code names KDS-2010, SeReMABI) is a potent, highly selective, and reversible monoamine oxidase B (MAO-B) inhibitor which is under development for the treatment of Alzheimer’s disease and obesity.[1][2][3][4] It is taken by mouth.[1] Tisolagiline is being developed by NEUROBiOGEN and Scilex Bio.[1][2] As of December 2024, it is in phase 2 clinical trials for Alzheimer’s disease and obesity.[1][2] Parkinson’s disease is a …

Bemfivastatin, PPD 10558, RBx 10558

Bemfivastatin, PPD 10558, RBx 10558 cas 805241-79-6 Molecular Weight 588.67 Formula C34H37FN2O6 Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin. Bemfivastatin enhances the activity of liver extraction. Bemfivastatin exhibits little developmental toxicity effects in pregnant rats and rabbits via daily oral doses during organogenesis period. The no observed adverse …

Umifoxolaner, ML 878

Umifoxolaner, ML 878 CAS 2021230-37-3 Molecular Weight 643.86 Formula C26H16ClF10N3O3 umifoxolaner (ML-878) is a γ-aminobutyric acid (GABA) regulated chloride channels antagonist. Umifoxolaner is an anti-parasitic agent Animals such as mammals and birds are often susceptible to parasite infestations/infections. These parasites may be ectoparasites, such as insects, and endoparasites such as filariae and other worms. Domesticated animals, such …

Bavtavirine

Bavtavirine, CAS 1956373-71-9 C26H20N6 416.48 Benzonitrile, 4-[[4-amino-8-[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]-2-quinazolinyl]amino]- Gilead Sciences, Inc.; Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i. Bavtavirine is a potent non-nucleoside reverse transcriptase inhibitors (NNRTIs). Bavtavirine is part of highly active antitiretroviral therapy (HAART) treatment regimen. Bavtavirine can be used for HIV disease research. SCHEME PATENT WO2016105564 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016105564&_cid=P11-M8QXHF-67832-1 A mixture of compound 2a (100 …