WO 2016200930, New patent, Citarinostat, Acetylon Pharmaceuticals Inc

It’s only fair to share…   WO 2016200930, New patent, Citarinostat, Acetylon Pharmaceuticals Inc citarinostat Acetylon Pharmaceuticals Inc (WO2016200930) METHODS OF MAKING PROTEIN DEACETYLASE INHIBITORS (I) Compound (I) is disclosed in U.S. Patent No. 8,148,526 as an HDAC inhibitor. Example 2 of U.S. Patent Application Publication No. 2015/0099744 discloses a synthesis of compound (I). As detailed …

Calcifediol, カルシフェジオール

It’s only fair to share… Calcifediol カルシフェジオール Ro 8-8892 U 32070E (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-trien-3,25-diol [German] [ACD/IUPAC Name] (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-triene-3,25-diol [ACD/IUPAC Name] (3S,5Z,7E,20R)-9,10-Sécocholesta-5,7,10-triène-3,25-diol [French] [ACD/IUPAC Name] 19356-17-3 [RN] 1H-indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-a,a,e,7a-tetramethyl-, (eR,1R,3aS,4E,7aR)- 25(OH)D3 25-(OH)Vitamin D3 25-hydroxy Vitamin D3 25-HYDROXYCHOLECALCIFEROL-D6 25-hydroxycholecalciferolmonohydrate 25-hydroxyvitamin D 3-{2-[1-(5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexanol 4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-?,?,?,7a-tetramethyl-(?R,1R,3aS,4E,7aR)-1H-indene-1-pentanol Molecular form.: C₂₇H₄₄O₂ Appearance: White to Off-White Solid Melting Point: 75-93ºC Mol. Weight: 400.64 Calcifediol …

Balsalazide

It’s only fair to share… Balsalazide 80573-04-2; Colazal; Balsalazide Disodium; AC1NSFNR; P80AL8J7ZP; Molecular Formula: C17H15N3O6 Molecular Weight: 357.322 g/mol   (3E)-3-[[4-(2-carboxyethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylic acid  DISODIUMDIHYDRATE CAS Number 150399-21-6 Weight Average: 437.316 Monoisotopic: 437.08110308 Chemical Formula C17H17N3Na2O8 Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the brand names Giazo, …

CENTANAFADINE

It’s only fair to share… Centanafadine; UNII-D2A6T4UH9C; EB-1020 free base; D2A6T4UH9C; 924012-43-1 CTN SR; EB-1020; EB-1020 SR WO 2007016155 Molecular Formula: C15H15N Molecular Weight: 209.292 g/mol Phase II Attention-deficit hyperactivity disorder No development reported Major depressive disorder; Neuropathic pain Most Recent Events 20 Dec 2016 Neurovance plans a phase III trial for Attention-deficit hyperactivity disorder 27 Jul 2016 Efficacy data from …

Niraparib; MK 4827

It’s only fair to share… MK-4827,(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Niraparib; MK 4827; MK4827 UNII:HMC2H89N35 Antineoplastic, Poly(ADP-ribose) Polymerase Inhibitors 1038915-60-4 CAS, free form 1038915-64-8 CAS HYDROCHLORIDE 1613220-15-7 cas TOSYLATE MONOHYDRATE 1038915-73-9  TOSYLATE MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against …

FDA grants accelerated approval to new treatment for advanced ovarian cancer , Rubraca(rucaparib)

It’s only fair to share… The U.S. Food and Drug Administration today granted accelerated approval to Rubraca (rucaparib) to treat women with a certain type of ovarian cancer. Rubraca is approved for women with advanced ovarian cancer who have been treated with two or more chemotherapies and whose tumors have a specific gene mutation (deleterious …

DNDI-VL-2098

It’s only fair to share… DNDI-VL-2098 CAS 681492-17-1 (R)-2-Methyl-6-nitro-2-(4-trifluoromethoxyphenoxymethyl)-2,3-dihydroimidazo[2,1-b]oxazole Watch this post, will be updated……….. MF C14 H12 F3 N3 O5, MW 359.26 Imidazo[2,1-b]oxazole, 2,3-dihydro-2-methyl-6-nitro-2-[[4-(trifluoromethoxy)phenoxy]methyl]-, (2R)- Hidetsugu Tsubouchi, Hirofumi Sasaki, Hideaki Kuroda, Motohiro Itotani, Takeshi Hasegawa, Yoshikazu Haraguchi, Takeshi Kuroda, Takayuki Matsuzaki, Kuninori Tai, Makoto Komatsu, Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige, Yuji Seike, Masanori Kawasaki, …

Citarinostat

It’s only fair to share… Citarinostat Treatment of Hematological Malignancies,  Molecular Formula, C24-H26-Cl-N5-O3, Molecular Weight, 467.9544, RN: 1316215-12-9 UNII: 441P620G3P 2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide 2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide 5-Pyrimidinecarboxamide, 2-((2-chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)- ACY-241; HDAC-IN-2 Histone deacetylase-6 inhibitor Acute myelogenous leukemia; Cancer; Mantle cell lymphoma; Multiple myeloma Mechanism of ActionHDAC6 protein inhibitors Highest Development Phases Phase IIMultiple myeloma Phase IMalignant melanoma; Non-small cell lung cancer; Solid …

FDA approves Eucrisa (crisaborole) for eczema

It’s only fair to share… News Release FDA approves Eucrisa for eczema The U.S. Food and Drug Administration today approved Eucrisa (crisaborole) ointment to treat mild to moderate eczema (atopic dermatitis) in patients two years of age and older. Read more. For Immediate Release December 14, 2016 Release The U.S. Food and Drug Administration today …