It’s only fair to share… Civorebrutinib WS-413, 933NK55FMX 5-amino-3-[4-(5-chloropyridin-2-yl)oxyphenyl]-1-[(6R)-4-cyano-4-azaspiro[2.5]octan-6-yl]pyrazole-4-carboxamide Molecular Weight 463.92 Formula C23H22ClN7O2 CAS No. 2155853-43-1 Civorebrutinib (WS-413) is a Bruton’s tyrosine kinase inhibitor with antineoplastic effect. Scheme Patent Zhejiang Yukon Pharma Co., Ltd. WO2017198050 WO2019091440 WO2019091438 PATENT WO2019091441 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019091441&_cid=P10-MADPL7-76599-1 Example 1 [0116]Preparation of (R)-5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-(4-cyano-4-azaspiro[2.5]octan-6-yl)-1H-pyrazole-4-carboxamide (Compound 1) Step 1 [0119] [0120]DIPEA (185 g, 1.44 …