It’s only fair to share… Momelotinib 414.47, C23H22N6O2, 1056634-68-4 FDA 2023, Ojjaara, To treat intermediate or high-risk myelofibrosis in adults with anemiaDrug Trials Snapshot N-(Cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide N-(Cyanomethyl)-4-[2-[4-(4-morpholinyl)phenylamino]pyrimidin-4-yl]benzamide Jak2 tyrosine kinase inhibitor; Jak1 tyrosine kinase inhibitor Inflammatory disease; Myelofibrosis; Myeloproliferative disorder; Pancreatic ductal adenocarcinoma; Polycythemia vera CYT 387; CYT-387; momelotinib) GS-0387 CYT387 sulfate saltCAS No: 1056636-06-6 CYT387 Mesylate CAS …
Tag «APPROVALS 2023»
Velagliflozin
It’s only fair to share… Velagliflozin 2-[(4-cyclopropylphenyl)methyl]-4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzonitrile Velagliflozin L-proline H2O Velagliflozin, sold under the brand name Senvelgo, is an antidiabetic medication used for the treatment of cats.[2][4][5] Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor.[6] It is taken by mouth.[2] Velagliflozin is the active ingredient of the first oral liquid medication approved by the Food and Drug Administration for the treatment of …
Befotertinib
It’s only fair to share… Befotertinib D-0316, 0XT2CPR891 CAS No. : 1835667-63-4, MESYLATE CAS No. 2226167-02-6 Molecular Weight 567.61 Formula C29H32F3N7O2 Befotertinib (D-0316) is an orally active EGFR tyrosine kinase inhibitor. Befotertinib can inhibit the proliferation of tumor cells. Befotertinib can be used in the research of EGFR T790M-positive non-small cell lung cancer (NSCLC). Befotertinib is an orally available inhibitor of the epidermal …
Iruplinalkib
It’s only fair to share… Iruplinalkib CAS No. : 1854943-32-0 Molecular Weight 569.08 Formula C29H38ClN6O2P 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)phenyl]pyrimidine-2,4-diamine Iruplinalkib (WX-0593) is an orally active and selective ALK/ROS1 inhibitor. Iruplinalkib can effectively inhibit tyrosine autophosphorylation of ALK and mutant ALK, EGFR, with the IC50 between 5.38 and 16.74 nM. Iruplinalkib is also a suppressive agent of the transporter MATE1, MATE2K, P-gp and BCRP. Iruplinalkib can be used in the study of non-small …
Ropotrectinib
It’s only fair to share… Ropotrectinib WeightAverage: 355.373Monoisotopic: 355.144453003 Chemical FormulaC18H18FN5O2 Repotrectinib, sold under the brand name Augtyro, is an anti-cancer medication used for the treatment of non-small cell lung cancer.[2][5] It is taken by mouth.[2] Repotrectinib is an inhibitor of proto-oncogene tyrosine-protein kinase ROS1 (ROS1) and of the tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC.[2] The most common adverse reactions include dizziness, dysgeusia, peripheral neuropathy, constipation, dyspnea, ataxia, fatigue, cognitive disorders, …
Vamorolone
It’s only fair to share… Vamorolone CAS 13209-41-1 Molecular Weight 356.46 Formula C22H28O4 Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects. Vamorolone, sold under the brand name Agamree, is a synthetic corticosteroid, which is used for the treatment of Duchenne muscular …
BEXAGLIFLOZIN
It’s only fair to share… BexagliflozinTHR1442; THR-1442, EGT 0001442; EGT1442CAS :1118567-05-7(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[2- (cyclopropyloxy) ethoxy] phenyl} methyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H- pyran-3,4,5-triol D-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1S)- (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1-[4-Chloro-3-[4-[2-(cyclopropyloxy)ethoxy]benzyl]phenyl]-1-deoxy-beta-D-glucopyranose1,5-Anhydro-1(S)-[4-chloro-3-[4-[2-(cyclopropyloxy)ethoxy]benzyl]phenyl]-D-glucitol (1S)-1,5-anhydro-1-C-[4-chloro-3-({4-[2- (cyclopropyloxy)ethoxy]phenyl}methyl)phenyl]-D-glucitol Chemical Formula: C24H29ClO7Exact Mass: 464.16018 Mechanism of Action:SGLT2 inhibitor, Sodium-glucose transporter 2 inhibitorsIndication:Type 2 diabetes FDA APPROVED 1/20/2023 Brenzavvy To improve glycemic control in adults with type 2 diabetes mellitus as an …
Zilucoplan
It’s only fair to share… Zilucoplan CAS 1841136-73-9 YG391PK0CC, RA101495, WHO 10602 3562 g/mol, C172H278N24O55 Zilucoplan lso designated as RA101495, is the active principle of Zilbrysq®, commercialized by UCB Pharma S.A. It is a 3.5 kDa synthetic macrocyclic peptide composed of 15 amino acid residues, including four unnatural amino acids [27]. The amino acid residues composition …
Gepirone
It’s only fair to share… Gepirone CAS 83928-76-1 BMY 13805, MJ 13805, ORG 13011, Gepirona, JW5Y7B8Z18 FDA 9/22/2023, Gepirone is indicated for the treatment of major depressive disorder (MDD) in adults Exxua WeightAverage: 359.474Monoisotopic: 359.232125194Chemical FormulaC19H29N5O2 4,4-dimethyl-1-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}piperidine-2,6-dione Ingredient UNII CAS InChI Key Gepirone Hydrochloride 80C9L8EP6V 83928-66-9 DGOCVISYYYQFEP-UHFFFAOYSA-N Gepirone, sold under the brand name Exxua, is a medication used …
Lotilaner
It’s only fair to share… Lotilaner 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide FDA Xdemvy, 7/25/2023, To treat Demodex blepharitisDrug Trials Snapshot Lotilaner, sold under the brand name Xdemvy, is an ectoparasiticide (anti-parasitic) medication used for the treatment of blepharitis (inflammation of the eyelid) caused by infestation by Demodex (tiny mites).[1][7] It is used as an eye drop.[1] It was approved for medical use in the United States in July 2023.[1][7][8][9] The US Food …