Tag «Department of Chemistry and Center for Molecular Discovery (BU-CMD)»

Novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8),

It’s only fair to share… CAS 1620779-53-4 MF C22H20N4O2, MW 372.4 (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide 1H-1,2,3-Triazole-1-acetamide, 5-(2-cyclopropylethynyl)-N-hydroxy-4-phenyl-α-(phenylmethyl)-, (αS)- Applicants: TRUSTEES OF BOSTON UNIVERSITY DANA-FARBER CANCER INSTITUTE, INC. Inventors: Aaron Beaty BEELER John A. PORCO, JR. Oscar J. INGHAM James E. BRADNER As histone proteins bind DNA prior to transcription, their biochemical action plays a critical role in the regulation …