It’s only fair to share… Sparsentan (PS433540,RE-021) C32H40N4O5S Average mass592.749 FDA APPROVED 2023/2/17, Filspari 4′-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2′-(ethoxymethyl)-[1,1′-biphenyl]-2-sulfonamide 4′-[(2-Butyl-4-oxo-1.3-diazaspiro[4.41non-l-en-3-yl)methvn-N-(3,4- dimethyl-5-isoxazolyl)-2′-ethoxymethyl [ 1 , l’-biphenyll -2-sulfonamide SparsentanPS433540; RE-021, formerly known as DARACAS :254740-64-24-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5- dimethylisoxazol-3-yl)-2-(ethoxymethyl)biphenyl-2-sulfonamideMechanism of Action:acting as both an Endothelin Receptor Antagonist (ERA) and Angiotensin Receptor Blocker (ARB).Indication: Focal Segmental Glomerulosclerosis (FSGS).Focal Segmental Glomerulosclerosis (FSGS) is a rare …
Tag «FDA 2023»
Momelotinib
It’s only fair to share… Momelotinib 414.47, C23H22N6O2, 1056634-68-4 FDA 2023, Ojjaara, To treat intermediate or high-risk myelofibrosis in adults with anemiaDrug Trials Snapshot N-(Cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide N-(Cyanomethyl)-4-[2-[4-(4-morpholinyl)phenylamino]pyrimidin-4-yl]benzamide Jak2 tyrosine kinase inhibitor; Jak1 tyrosine kinase inhibitor Inflammatory disease; Myelofibrosis; Myeloproliferative disorder; Pancreatic ductal adenocarcinoma; Polycythemia vera CYT 387; CYT-387; momelotinib) GS-0387 CYT387 sulfate saltCAS No: 1056636-06-6 CYT387 Mesylate CAS …
Ropotrectinib
It’s only fair to share… Ropotrectinib WeightAverage: 355.373Monoisotopic: 355.144453003 Chemical FormulaC18H18FN5O2 Repotrectinib, sold under the brand name Augtyro, is an anti-cancer medication used for the treatment of non-small cell lung cancer.[2][5] It is taken by mouth.[2] Repotrectinib is an inhibitor of proto-oncogene tyrosine-protein kinase ROS1 (ROS1) and of the tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC.[2] The most common adverse reactions include dizziness, dysgeusia, peripheral neuropathy, constipation, dyspnea, ataxia, fatigue, cognitive disorders, …
Vamorolone
It’s only fair to share… Vamorolone CAS 13209-41-1 Molecular Weight 356.46 Formula C22H28O4 Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects. Vamorolone, sold under the brand name Agamree, is a synthetic corticosteroid, which is used for the treatment of Duchenne muscular …
BEXAGLIFLOZIN
It’s only fair to share… BexagliflozinTHR1442; THR-1442, EGT 0001442; EGT1442CAS :1118567-05-7(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[2- (cyclopropyloxy) ethoxy] phenyl} methyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H- pyran-3,4,5-triol D-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1S)- (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1-[4-Chloro-3-[4-[2-(cyclopropyloxy)ethoxy]benzyl]phenyl]-1-deoxy-beta-D-glucopyranose1,5-Anhydro-1(S)-[4-chloro-3-[4-[2-(cyclopropyloxy)ethoxy]benzyl]phenyl]-D-glucitol (1S)-1,5-anhydro-1-C-[4-chloro-3-({4-[2- (cyclopropyloxy)ethoxy]phenyl}methyl)phenyl]-D-glucitol Chemical Formula: C24H29ClO7Exact Mass: 464.16018 Mechanism of Action:SGLT2 inhibitor, Sodium-glucose transporter 2 inhibitorsIndication:Type 2 diabetes FDA APPROVED 1/20/2023 Brenzavvy To improve glycemic control in adults with type 2 diabetes mellitus as an …
Zilucoplan
It’s only fair to share… Zilucoplan CAS 1841136-73-9 YG391PK0CC, RA101495, WHO 10602 3562 g/mol, C172H278N24O55 Zilucoplan lso designated as RA101495, is the active principle of Zilbrysq®, commercialized by UCB Pharma S.A. It is a 3.5 kDa synthetic macrocyclic peptide composed of 15 amino acid residues, including four unnatural amino acids [27]. The amino acid residues composition …
Gepirone
It’s only fair to share… Gepirone CAS 83928-76-1 BMY 13805, MJ 13805, ORG 13011, Gepirona, JW5Y7B8Z18 FDA 9/22/2023, Gepirone is indicated for the treatment of major depressive disorder (MDD) in adults Exxua WeightAverage: 359.474Monoisotopic: 359.232125194Chemical FormulaC19H29N5O2 4,4-dimethyl-1-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}piperidine-2,6-dione Ingredient UNII CAS InChI Key Gepirone Hydrochloride 80C9L8EP6V 83928-66-9 DGOCVISYYYQFEP-UHFFFAOYSA-N Gepirone, sold under the brand name Exxua, is a medication used …
Lotilaner
It’s only fair to share… Lotilaner 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide FDA Xdemvy, 7/25/2023, To treat Demodex blepharitisDrug Trials Snapshot Lotilaner, sold under the brand name Xdemvy, is an ectoparasiticide (anti-parasitic) medication used for the treatment of blepharitis (inflammation of the eyelid) caused by infestation by Demodex (tiny mites).[1][7] It is used as an eye drop.[1] It was approved for medical use in the United States in July 2023.[1][7][8][9] The US Food …
Flotufolastat F 18
It’s only fair to share… Flotufolastat F 18 gallium;2-[7-[(1S)-1-carboxy-4-[[(2R)-1-[[(1R)-1-carboxy-5-[[4-[[(4R)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(1S)-1,3-dicarboxypropyl]carbamoylamino]butanoyl]amino]butyl]amino]-4-oxobutanoyl]amino]pentyl]amino]-3-[[4-[ditert-butyl(fluoranyl)silyl]benzoyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutyl]-4,10-bis(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate WeightAverage: 1470.63Monoisotopic: 1469.662295938 Chemical FormulaC63H99FN12O25Si 2639294-14-5 CAS FDA 2023, Posluma, 5/25/2023, To use with positron emission tomography imaging in certain patients with prostate cancerDrug Trials Snapshot Flotufolastat (18F), sold under the brand name Posluma, is a radioactive diagnostic agent for use with positron emission tomography (PET) imaging for prostate cancer.[1] The active ingredient is flotufolastat …
Durlobactam
It’s only fair to share… Durlobactam CAS 1467829-71-5 WeightAverage: 277.25Monoisotopic: 277.03685626 Chemical FormulaC8H11N3O6S Ingredient UNII CAS InChI Key Durlobactam sodium F78MDZ9CW9 1467157-21-6 WHHNOICWPZIYKI-IBTYICNHSA-M FDA 5/23/2023, Xacduro, To treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complexPress ReleaseDrug Trials Snapshots (2S,5R)-2-CARBAMOYL-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL SULFATE SULFURIC ACID, MONO((2S,5R)-2-(AMINOCARBONYL)-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL) ESTERETX 2514, ETX-2514, ETX2514, WHO …