Tag «Tagtociclib»

Tagtociclib

It’s only fair to share… Tagtociclib (PF-07104091), 2460249-19-6, MW 404.5, C19H28N6O4 CAS  2733575-91-0 HYDRATE Molecular Weight HYDRATE 422.48 Formula C19H30N6O5 [(1R,3S)-3-[3-[[5-(methoxymethyl)-2-methylpyrazole-3-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-propan-2-ylcarbamate PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2). Phase IIBreast cancer; Solid tumours Phase I/IINon-small cell lung …