It’s only fair to share… Danicopan USFDA 3/29/2024, To treat extravascular hemolysis with paroxysmal nocturnal hemoglobinuria, Voydeya C26H23BrFN7O3 580.418 1903768-17-1 (2S,4R)-1-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide ACH 0144471 ACH-4471 ACH0144471 ALXN 2040 ALXN-2040 ALXN2040 Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria.[2] It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and …
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INAXAPLIN
It’s only fair to share… INAXAPLIN, 2446816-88-0 2446816-88-0 S2SJ2RVZ6Y UNII-S2SJ2RVZ6Y C21H18F3N3O3 3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl]propanamide Inaxaplin (VX-147) is a small-molecule apolipoprotein L1 inhibitor developed by Vertex Pharmaceuticals for APOL1-mediated kidney disease. In preliminary studies the drug has shown promise in treating people with kidney disease and multiple gain of function mutations on the APOL1 gene.[1][2] FSGS is a disease of the …
Golcadomide (CC-99282)
It’s only fair to share… Golcadomide (CC-99282) Molecular Weight 535.57 Formula C28H30FN5O5 CAS No. 2379572-34-4 (S)-2-(2,6-Dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione 2-[(3S)-2,6-Dioxo-3-piperidinyl]-4-[[[2-fluoro-4-[[3-(4-morpholinyl)-1-azetidinyl]methyl]phenyl]methyl]amino]-1H-isoindole-1,3(2H)-dione (ACI) (S)-2-(2,6-Dioxopiperidin-3-yl)-4-[[2-fluoro-4-[(3-morpholinoazetidin-1-yl)methyl]benzyl]amino]isoindoline-1,3-dione CC 1007548 CC 99282 CC-99282 CC1007548 Golcadomide WHO 12305 Golcadomide HCl, 2639939-36-7 Chemical Name: CC-99282 Hydrochloride; 2-[(3S)-2,6-Dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione hydrochloride Novel potent and orally active cereblon (CRBN) E3 ligase modulator Ref: https://www.sciencedirect.com/science/article/abs/pii/S0268960X22000686 Golcadomide is a modulator of the …
Igermetostat
It’s only fair to share… Igermetostat C32H46N4O4. 550.73 2409538-60-7 2KES6YSH8D INN 12655 BENZAMIDE, N-((1,2-DIHYDRO-4,6-DIMETHYL-2-OXO-3-PYRIDINYL)METHYL)-3-(ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO)-2-METHYL-5-((TRANS-3-(1-PIPERIDINYL)CYCLOBUTYL)OXY)-IGERMETOSTATIGERMETOSTAT [INN]N-((1,2-DIHYDRO-4,6-DIMETHYL-2-OXO-3-PYRIDINYL)METHYL)-3-(ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO)-2-METHYL-5-((TRANS-3-(1-PIPERIDINYL)CYCLOBUTYL)OXY)BENZAMIDEN-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-(ETHYL(OXAN-4-YL)AMINO)-2-METHYL-5-(((1R,3R)-3-(PIPERIDIN-1-YL)CYCLOBUTYL)OXY)BENZAMIDE IGERMETOSTAT is a small molecule drug with a maximum clinical trial phase of II and has 1 investigational indication. SCHEME PATENT https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020020374&_cid=P22-LR1SQG-34075-1 PATENT US20230382898 https://patentscope.wipo.int/search/en/detail.jsf?docId=US415363922&_cid=P22-LR1S46-25135-1 The compound has been disclosed in patent WO2020020374A1. It is an enhancer of Zeste …
Obeldesivir
It’s only fair to share… Obeldesivir, 2647441-36-7 361.35 g/mol C16H19N5O5 [(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methyl 2-methylpropanoate Q55KCM7PXB; ATV006; UNII-Q55KCM7PXB Scheme NEW A END OF PAGE CHECK Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient treatment of COVID-19 in high risk patients.[1][2] The purpose of the isobutyric ester modification on obeldesivir is to improve the oral bioavailability of the parent nucleoside, GS-441524. …
Oditrasertib
It’s only fair to share… Oditrasertib SAR443820; DNL788 Molecular Formula C14H15F2N3O2 Molecular Weight 295.2846 UNII-I1YQT8HC89 I1YQT8HC89 cas 2252271-93-3 4-(3,3-Difluoro-2,2-dimethylpropanoyl)-3,5-dihydro-2H-pyrido(3,4-F)(1,4)oxazepine-9-carbonitrile PYRIDO(3,4-F)-1,4-OXAZEPINE-9-CARBONITRILE, 4-(3,3-DIFLUORO-2,2-DIMETHYL-1-OXOPROPYL)-2,3,4,5-TETRAHYDRO- Oditrasertib is a serine/threonine kinase (STK) inhibitor. Oditrasertib (SAR443820) is an orally active, BBB-penetrable and selective reversible inhibitor of RIPK1. Oditrasertib can be used in the research of chronic inflammatory central nervous system diseases, such …
ORZILOBEN
It’s only fair to share… ORZILOBEN, CAS 1555822-28-0 2-methyl-3-(pentyloxy)benzoic acid Molecular Weight 222.28 Formula C13H18O3 Orziloben is a medium chain fatty acid (MCFA) analogue[1]. OriginatorPronova BioPharma DeveloperNorthSea Therapeutics ClassAntifibrotics; Hepatoprotectants; Omega 3 fatty acids; Unsaturated fatty acids Mechanism of ActionUndefined mechanism 28 Jan 2025No recent reports of development identified for phase-I development in Liver-disorders(In volunteers) …
Opevesostat
It’s only fair to share… Opevesostat ODM208 2231294-96-3Chemical Formula: C21H26N2O5S Molecular Weight: 418.508 2-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-5-{[1-(methanesulfonyl)piperidin-4-yl]methoxy}-4H-pyran-4-one Opevesostat tosylate 2832831-08-8 Molecular Formula C21H26N2O5S.C7H8O3S Molecular Weight 590.71 4H-Pyran-4-one, 2-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-5-[[1-(methylsulfonyl)-4-piperidinyl]methoxy]-, 4-methylbenzenesulfonate (1:1) 2-((1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL)-5-((1-(METHYLSULFONYL)-4-PIPERIDINYL)METHOXY)-4H-PYRAN-4-ONE, TOSYLATE SCHEME SEE AT THE END OF PAGE Opevesostat is an investigational new drug being developed for the treatment of metastatic castration-resistant prostate cancer (mCRPC).[1] It is a non-steroidal, selective inhibitor of CYP11A1 (cholesterol …
Sotuletinib HCl
It’s only fair to share… Sotuletinib HCl CAS: 2222138-31-8 (HCl) Chemical Formula: C20H23ClN4O3S Molecular Weight: 434.939 7W3V82OQ0P Synonym: Sotuletinib HCl; Sotuletinib hydrochloride, Sotuletinib monohydrochloride, BLZ945; BLZ 945; BLZ-945; IUPAC/Chemical Name: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide hydrochloride 2-PYRIDINECARBOXAMIDE, 4-((2-(((1R,2R)-2-HYDROXYCYCLOHEXYL)AMINO)-6-BENZOTHIAZOLYL)OXY)-N-METHYL- Sotuletinib, also known as BLZ945, is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune …
TACACICLIB, AUR-102, AURIGENE
It’s only fair to share… Tacaciclib 2768774-66-7 AUR-102 Tacaciclib SCHEMBL24548621 GTPL12880 528.6 g/mol C30H36N6O3 INN 12755 UNI D3G4JKK1MA (2S)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-methyl-2-[3-[6-[[(E)-4-morpholin-4-ylbut-2-enoyl]amino]pyridin-3-yl]phenyl]butanamide (αS)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]benzeneacetamide Benzeneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]-, (αS)- Tacaciclib is a CDK inhibitor, antineoplastic effect. The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders …