Category «Coronavirus disease»

EpiVacCorona

It’s only fair to share… Origin of EpiVacCorona antigenes MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNSSSNNNNNNNNNNLGDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDLSKQLQQSMSSADSTQA. “Carrier protein sequence”. EpiVacCorona Federal Budgetary Research Institution State Research Center of Virology and Biotechnology peptide, russia PATENT https://www.fips.ru/registers-doc-view/fips_servlet?DB=RUPAT&DocNumber=2743594&TypeFile=html RU 2 743 594 RU 2 743 593 RU 2 743 595 RU 2 738 081 Science (Washington, DC, United States) (2021), 372(6538), 116-117. EpiVacCorona (Russian: ЭпиВакКорона, tr. EpiVakKorona) is a peptide-based vaccine against COVID-19 developed by the VECTOR center of …

ZF 2001, ZIFIVAX

It’s only fair to share… Republic of Uzbekistan Oʻzbekiston Respublikasi  (Uzbek) Flag State emblem ZF2001 ZIFIVAX CAS 2609662-31-7 A COVID-19 vaccine comprising a dimeric form of SARS-CoV-2 receptor-binding domain (RBD) produced in China hamster ovary (CHO) cells and adjuvanted with aluminum hydroxide (Anhui Zhifei Longcom/Institute of Microbiol. China Academy of Sciences) Recombinant vaccine Anhui Zhifei Longcom Biopharmaceutical, …

Colchicine

It’s only fair to share… Colchicine CAS Registry Number: 64-86-8 CAS Name: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide Molecular Formula: C22H25NO6 Molecular Weight: 399.44 CSIR-Laxai Life Sciences get DCGI nod for clinical trials Colchicine on Covid patients https://www.thehindubusinessline.com/news/csir-laxai-life-sciences-get-dcgi-nod-for-clinical-trials-colchicine-on-covid-patients/article34795126.ece?fbclid=IwAR21MOLpbdhdTR-owHYYWC-xG1DZEECOg1PcYRoMICoAwVkV7TWO2CgZQWA It is an important therapeutic intervention for Covid-19 patients with cardiac co-morbidities and also for reducing proinflammatory cytokines The Council of Scientific & Industrial Research (CSIR), …

Corbevax, BioE COVID-19, BECOV2D

It’s only fair to share… Corbevax BioE COVID-19, BECOV2D the Baylor College of Medicine in Houston, United States, Dynavax Technologies Adjuvanted protein subunit vaccine Corbevax is a “recombinant protein sub-unit” vaccine, which means it is made up of a specific part of SARS-CoV-2 — the spike protein on the virus’s surface. The spike protein allows the virus to enter …

Casirivimab

It’s only fair to share… (Heavy chain) QVQLVESGGG LVKPGGSLRL SCAASGFTFS DYYMSWIRQA PGKGLEWVSY ITYSGSTIYY ADSVKGRFTI SRDNAKSSLY LQMNSLRAED TAVYYCARDR GTTMVPFDYW GQGTLVTVSS ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK (Light chain) DIQMTQSPSS …

ZyCoV-D

It’s only fair to share… ZyCoV-D CAS 2541524-47-2 DNA vaccine construct encoding a spike protein antigen of SARS-CoV-2 virus (Zydus-Cadila) https://zyduscadila.com/public/pdf/Covid%2019_Booklet_9th%20FEB_FINAL.pdf http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=51254&EncHid=&userName=ZyCoV-D bioRxiv (2021), 1-26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423510/ ZyCoV-D | (CTRI/2020/07/026352, 2020, CTRI/2020/07/026352, 2020; Myupchar, 2020) ZYDUS CADILA ZyCoV-D is a genetically engineered DNA plasmid based vaccine encoding for the membrane proteins of the virus. The clinical trials to study the immunogenicity, …

2-Deoxy-D-glucose

It’s only fair to share… 2-Deoxy-D-glucose Molecular FormulaC6H12O5 Average mass164.156 Da 2-Deoxy-D-glucose (4R,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol (4R,5S,6R)-6-(Hydroxyméthyl)tétrahydro-2H-pyran-2,4,5-triol 154-17-6 [RN] 2-Deoxy-D-arabino-hexopyranose 2-deoxy-D-glucopyranose 2-deoxyglucose 2-DG D-arabino-2-Desoxyhexose D-arabino-Hexopyranose, 2-deoxy- [ (4R,5S,6R)-6-(Hydroxymethyl)oxane-2,4,5-triol 2-deoxyglucopyranose 2-deoxymannopyranose 2-dGlc 61-58-5 [RN] 77252-38-1 [RN] D-arabino-2-Deoxyhexose glucitol, 2,5-anhydro- 2-Deoxy-D-arabino-hexose 2 DG 2-Deoxy-D-glucose 2-Deoxy-D-mannose 2-Deoxyglucose 2-Desoxy-D-glucose Ba 2758 D-Glucose, 2-deoxy- NSC 15193 2-Deoxy-D-glucose CAS Registry Number: 154-17-6 CAS Name: 2-Deoxy-D-arabino-hexose Additional Names: D-arabino-2-desoxyhexose; 2-deoxyglucose; 2-DG Manufacturers’ …

Ramatroban

It’s only fair to share… Ramatroban   Formula C21H21FN2O4S  CAS  116649-85-5 Mol weight 416.4658   (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid (+)-(3R)-3-(p-fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid; (+)-3-(4-fluorophenylsulfonamido)-9-(2-carboxyethyl)-1,2,3,4-tetrahydrocarbazole 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid Manufacturers’ Codes: Bay u 3405 3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid BAY u 3405 BAY u 3406 BAY u-3405 BAY u3405 ramatroban Trademarks: Baynas (Bayer) MF: C21H21FN2O4S MW: 416.47 Percent Composition: C 60.56%, H 5.08%, F …

Pegylated Interferon alpha-2b, (PegIFN), Virafin

It’s only fair to share… DB00022 sequence CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMI QQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVR KYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE   CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE Chemical structure of peginterferon α-2a and α-2b. Abbreviations: PeG-IFN, peginterferon; IFN, interferon; Lys, lysine; His, histidine; Cys, cysteine; Ser, serine. Pegylated Interferon alpha-2b (PegIFN), Virafin Formula C860H1353N229O255S9 …

PF-07321332

It’s only fair to share… PF-07321332 https://clinicaltrials.gov/ct2/show/NCT04756531 PFIZER INITIATES PHASE 1 STUDY OF NOVEL ORAL ANTIVIRAL THERAPEUTIC AGENT AGAINST SARS-COV-2 Tuesday, March 23, 2021 – 11:00am In-vitro studies conducted to date show that the clinical candidate PF-07321332 is a potent protease inhibitor with potent anti-viral activity against SARS-CoV-2 This is the first orally administered coronavirus-specific …