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Cp2TiCl: An Ideal Reagent for Green Chemistry?

The development of Green Chemistry inevitably involves the development of green reagents. In this review, we highlight that Cp2TiCl is a reagent widely used in radical and organometallic chemistry, which shows, if not all, at least some of the 12 principles summarized for Green Chemistry, such as waste minimization, catalysis, safer solvents, toxicity, …

One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone Green Chem., 2017, Advance Article DOI: 10.1039/C7GC00578D, Communication Lei Song, Mingyuan Zheng, Jifeng Pang, Joby Sebastian, Wentao Wang, Minjie Qu, Jian Zhao, Xinhong Wang, Tao Zhang An efficient and environmentally benign method for the synthesis of 2-hydroxymethyl-5-methylpyrazine (HMMP) from biomass derived 1,3-dihydroxyacetone was developed. From the journal: …

Lisdexamphetamine

Lisdexamfetamine Molecular FormulaC15H25N3O Average mass263.379 Da 608137-32-2 [RN] Elvanse [Trade name] Hexanamide, 2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-, (2S)- Lisdexamfetamine L-lysine-d-amphetamine (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanimidic acid H645GUL8KJ L-lysine-(+)-amphetamine NRP104|Vyvanse® UNII:H645GUL8KJ UNII-H645GUL8KJ Vyvanse® CAS 608137-33-3 (2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide dimethanesulfonate https://www.google.com/patents/WO2005032474A2 Applicants: NEW RIVER PHARMACEUTICALS INC. [US/US]; The Governor Tyler, 1881 Grove Avenue, Radford, VA 24141 (US) (For All Designated States Except US). MICKLE, Travis [US/US]; (US) (For …

Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01289F, Paper Zhanhui Yang, Zhongpeng Zhu, Renshi Luo, Xiang Qiu, Ji-tian Liu, Jing-Kui Yang, Weiping Tang A highly efficient iridium catalyst is developed for the chemoselective reduction of aldehydes to alcohols in …

A Convenient and “Greener” Synthesis of Methyl Nitroacetate

Methyl Nitroacetate (2) Warning: Although no incidents occurred, the intermediates generated, as well as the end product, are energetic and should be handled as if they are explosive materials. It is essential that all reactions be conducted behind a blast shield and that proper protective equipment, including a face shield, be worn at all …

Selective synthesis of dimethoxyethane via directly catalytic etherification of crude ethylene glycol

Selective synthesis of dimethoxyethane via directly catalytic etherification of crude ethylene glycol Green Chem., 2017, Advance Article DOI: 10.1039/C7GC00659D, Paper Weiqiang Yu, Fang Lu, Qianqian Huang, Rui Lu, Shuai Chen, Jie Xu A potential diesel fuel additive, dimethoxyethane, was highly selectively produced via etherification of crude ethylene glycol over SAPO-34 From the journal: Green …

Selective hydrogenation of N-heterocyclic compounds using Ru nanocatalysts in ionic liquids

Selective hydrogenation of N-heterocyclic compounds using Ru nanocatalysts in ionic liquids Green Chem., 2017, 19,2762-2767 DOI: 10.1039/C7GC00513J, Communication Hannelore Konnerth, Martin H. G. Prechtl N-Heterocyclic compounds have been tested in the selective hydrogenation catalysed by small 1-3 nm sized Ru nanoparticles (NPs) embedded in various imidazolium based ionic liquids (ILs). http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC00513J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract From the …

Is water a suitable solvent for the catalytic amination of alcohols?

Is water a suitable solvent for the catalytic amination of alcohols? Green Chem., 2017, 19,2839-2845 DOI: 10.1039/C7GC00422B, Paper Johannes Niemeier, Rebecca V. Engel, Marcus Rose The catalytic aqueous-phase amination of biogenic alcohols with solid catalysts is reported for future development of renewable amine value-added chains. From the journal: Green Chemistry Is water a suitable solvent …

Efficient and Stereoselective Syntheses of Isomerically Pure 4-Aminotetrahydro-2H-thiopyran 1-Oxide Derivatives

trans-4-Aminotetrahydro-2H-thiopyran 1-Oxide Methanesulfonate (trans–3d-MsOH) Compound ……………….afforded trans-3d-MsOH (20 g, 68%) as a white crystalline solid. 1H NMR (300 MHz, DMSO-d6) δ 1.60–1.76 (2H, m), 2.16–2.29 (2H, m), 2.31 (3H, s), 2.68–2.81 (2H, m), 3.13–3.23 (2H, m), 3.27–3.35 (1H, m), 7.86 (3H, brs). 13C NMR (75 MHz, D2O) δ 24.98, 38.51, 46.18, 46.84. LCMS m/z calcd …

Tropylium salts as efficient organic Lewis acid catalysts for acetalization and transacetalization reactions in batch and flow

Tropylium salts as efficient organic Lewis acid catalysts for acetalization and transacetalization reactions in batch and flow Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01519D, Communication D. J. M. Lyons, R. D. Crocker, D. Enders, T. V. Nguyen Tropylium salts were reported as organic-Lewis acids to efficiently catalyze acetalization reactions in batch and flow. From the …