Category «Uncategorized»

IPI-549

It’s only fair to share… IPI-549 CAS 1693758-51-8 MF : C30H24N8O2 Molecular Weight: 528.576 (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Company Infinity Pharmaceuticals Inc. Description Small molecule inhibitor of phosphoinositide 3-kinase (PI3K) gamma Molecular Target Phosphoinositide 3-kinase (PI3K) gamma Mechanism of Action Phosphoinositide 3-kinase (PI3K) gamma inhibitor Therapeutic Modality Small molecule Latest Stage of Development Phase I Standard Indication Solid …

Ibipinabant Revisited

It’s only fair to share…   Ibipinabant cas  464213-10-3; UNII-O5CSC6WH1T; BMS-646256; SLV-319; Molecular Formula: C23H20Cl2N4O2S Molecular Weight: 487.4015 g/mol (4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N’-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N’-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N-methyl-4-phenyl-, (4S)- (4S)-3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N’-methyl-4-phenyl-1H-pyrazole-1-carboximidamide 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N‘-methyl-4-phenyl-, (4S)- (-)-(4S)-N-Methyl-N’-((4-chlorophenyl)sulfonyl)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1 H-pyrazole-1 -carboxamidine 4S)-(−)-3-(4-Chlorophenyl)-N-methyl-N‘-[(4-chlorophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine It was originally developed by Solvay, which was acquired by Abbott in 2010. SLV 319, UNII:O5CSC6WH1T, (S)-SLV 319, BMS 646256, JD 5001 Originator Solvay Class Antipsychotics; Imides; Obesity therapies; Pyrazoles; Small molecules; Sulfonamides …

1, 2-Bis(4-(4-4-nitrophenyl)piperazin-1-yl)ethanone for androgen sensitive prostatic disorders

It’s only fair to share…   1, 2-Bis(4-(4-4-nitrophenyl)piperazin-1-yl)ethanone Molecular Formula: C22H26N6O5 Molecular Weight: 454.47904 g/mol CAS 330633-91-5 CDRI-? For treatment of androgen sensitive prostatic disorders 1, 2-Bis(4-(4-4-nitrophenyl)piperazin-1-yl)ethanone In the quest for novel scaffolds for the management of androgen sensitive prostatic disorders like prostate cancer and benign prostatic hyperplasia, a series of twenty-six aryl/heteroaryl piperazine derivatives have …

PF-04745637

It’s only fair to share…   PF-04745637 cas 1917294-46-2 MW 509.00, MF C27 H32 Cl F3 N2 O2 Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]- rac-1-(4-Chlorophenyl)-N-f2-r4-hvdroxy-4-(trifluoromethyl)piperidin-1-vn-3-phenylpropyDcyclopentanecarboxamide PRODUCT PATENT WO-2016067143-A1 Applicants: PFIZER INC. [US/US]; 235 East 42nd Street New York, New York 10017 (US) Inventors: SWAIN, Nigel Alan; (GB). PRYDE, David Cameron; (GB). RAWSON, David James; (GB). RYCKMANS, Thomas; (GB). SKERRATT, Sarah Elizabeth; (GB). …

ALMOREXANT REVISITED

It’s only fair to share… Almorexant; ACT-078573;  (R)-2-((S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide; Almorexant (INN, codenamed ACT-078573) is an orexin antagonist, functioning as a competitive receptor antagonist of the OX1 and OX2 orexin receptors, which was being developed by the pharmaceutical companies Actelion and GSK for the treatment of insomnia. Development of the drug was abandoned in January 2011.[1] Development …

SNS-032, BMS-387032 A potent and selective Cdk inhibitor

It’s only fair to share… SNS 032, BMS-387032 N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide Cas 345627-80-7, MP 165-167° C M.Wt:380.53, Formula:C17H24N4O2S2   SNS 032, BMS-387032 HYDROCHLORIDE Formula C17H24N4O2S2 . HCl MW 380.5 . 36.5 CAS 345627-90-9   A potent and selective Cdk inhibitor Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM …

Evofosfamide, эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 ,

It’s only fair to share…   Evofosfamide, HAP-302 , TH-302, TH 302 эвофосфамид ,  إيفوفوسفاميد ,  艾伏磷酰胺 , Molecular Formula C9H16Br2N5O4P Average mass 449.036 Da (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N’-bis(2-bromoethyl)phosphorodiamidate (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl-N,N’-bis(2-bromethyl)phosphorodiamidat 918633-87-1 TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs Originator Threshold Pharmaceuticals Developer Merck KGaA; Threshold Pharmaceuticals Class Antineoplastics; Nitroimidazoles; Phosphoramide mustards; Small …

PF-04136309

It’s only fair to share… PF 4136309 PF4136309; PF 4136309; PF-4136309; PF04136309; PF4136309; PF-04136309; INCB8761; INCB 8761; INCB-8761 (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide N-[2-[(3S)-3-[[trans-4-Hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)benzamide N-[2-((3S)-3-[4-hydroxy-4-(4-pyrimidin-2-ylphenyl)cyclohexyl]aminopyrrolidin-1-yl)-2- oxoethyl]-3-(trifluoromethyl)benzamide 1341224-83-6 MF: C29H31F3N6O3 MW: 568.24097 CC chemokine receptor 2 (CCR2) antagonist Pfizer Limited Gary Burgess PF-4136309, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating …

ミチグリニドカルシウム水和物 , Mitiglinide calcium hydrate, 快如妥/Glufast

It’s only fair to share… Mitiglinide MF C19H25NO3 MW 315.407 Da Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes.[1] Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals. …

Duloxetine Hydrochloride, MSN, PATENT, US. 8362279

It’s only fair to share… US. 8362279 http://www.google.co.in/patents/US8362279 Inventors Manne Satyanarayana Reddy, Muppa Kishore Kumar, Srinivasan Thirumalai Rajan,Durgadas Shyla Prasad,  Original Assignee Msn Laboratories Limited Synthesis of duloxetine is described in detail in EP-A-273 658, EP-A-457 559 and EP-A-650965, starting from 2-acetylthiophene, an aminomethylation with dimethylamine and formaldehyde (Mannich reaction) is carried out in step-A. …