Category «Uncategorized»

Telcagepant Revisited

It’s only fair to share… Telcagepant, MK-0974 Molecular FormulaC26H27F5N6O3 Average mass566.523 Da 1-piperidinecarboxamide, N-[(3R,6S)-6-(2,3-difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-  CAS 781649-09-0 OriginatorMerck & Co ClassAntimigraines; Piperidines Mechanism of ActionCalcitonin gene-related peptide receptor antagonists Migraine is a neurovascular disorder characterized by severe, debilitating, and throbbing unilateral headache. Though a leading cause of disability, it is a highly prevalent disease with a clear unmet …

Nonsteroidal antiandrogens, (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide

It’s only fair to share…   C12 H17 Br N2 O3, 317.18 Butanamide, N-(2-bromo-6-methoxy-4-pyridinyl)-2-hydroxy-2,3-dimethyl-, (2S)- (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide (S)-N-(2-Bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide CAS 1433905-44-2 Nonsteroidal antiandrogens HPLC (Daicel Chiralpak IC 250 × 4.6 mm, 5 μm, n-heptane/IPA/TFA 930:70:1, 1 mL·min–1, 25 °C, UV 210 nm): tr (minor) = 5.1 min, tr (major) = 5.9 min. NMR 1H (400 MHz, DMSO-d6): 10.0 …

Brigatinib, Бригатиниб, بريغاتينيب , 布格替尼 ,

It’s only fair to share… Brigatinib, AP26113 Molecular Formula: C29H39ClN7O2P Molecular Weight: 584.102 g/mol CAS 1197953-54-0 2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]- Бригатиниб[Russian][INN] بريغاتينيب[Arabic][INN] 布格替尼[Chinese][INN] 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine AP-26113 MFCD29472221 UNII:HYW8DB273J In 2016, orphan drug designation was assigned to the compound in the U.S. for the treatment of ALK, ROS1 or EGFR-positive non-small cell lung cancer (NSCLC). WO 2009143389 PDT PAT Inventors Yihan …

HS-10168

It’s only fair to share… HS-10168 CAS 1394346-15-6 471.26, C21 H19 Cl2 F2 N2 O2 P (R)-(4-(6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine Oxide (HS-10168) 2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[4-(dimethylphosphinyl)-2-fluorophenyl]- HS-10168 is a potent and selective mesenchymal epithelial transition factor/anaplastic lymphoma kinase (c-Met/ALK) inhibitor that has advanced into Phase I clinical trials.(1, 2) Inventors Baihua Hu, Kan He, Minsheng Zhang Applicant Jiangsu Hansoh Pharmaceutical Co., …

Amtolmetin guacil, амтолметин гуацил , أمتولمتين غواسيل , 呱氨托美丁

It’s only fair to share… Amtolmetin guacil, ST-679, MED-15, Eufans CAS 87344-06-7 UNII: 323A00CRO9,  Molecular Formula, C24-H24-N2-O5, Molecular Weight, 420.463, 2-Methoxyphenyl 1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate Glycine, N-((5-benzoyl-1-methyl-1H-pyrrol-2-yl)acetyl)-, 2-methoxyphenyl ester Trade names: Amtoril®, Artricol®, Artromed® US 4578481, US 6288241, MEDOSAN RICERCA S.R.L. [IT/IT]; Via Cancelliera, 12 I-00040 Cecchina RM (IT) (For All Designated States Except US). SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE …

SL65.0102-10

It’s only fair to share… CAS 186348-69-6 1,4-Benzodioxin-5-carboxamide, 8-amino-7-chloro-N-(1,4-diazabicyclo[2.2.2]oct-2-ylmethyl)-2,3-dihydro-, (-)- MW, 352.82, C16 H21 Cl N4 O3 US5663173 (A)  –  N-[(1,4-diazabicyclo[2.2.2] oct-2-yl)methyl] benzamide derivatives, their preparations and their application in therapeutics SL65.0102-10 (-)-1,4-benzodioxin-5-carboxamide-8-amino-7-chloro-N-(1,4-diazabicyclo[2.2.2]oct-2- ylmethyl)-2,3-dihydro-, hydrochloride 1,4-Benzodioxin-5-carboxamide, 8-amino-7-chloro-N-(1,4-diazabicyclo[2.2.2]oct-2-ylmethyl)-2,3-dihydro-, hydrochloride (1:2), (-)- 1,4-Benzodioxin-5-carboxamide, 8-amino-7-chloro-N-(1,4-diazabicyclo[2.2.2]oct-2-ylmethyl)-2,3-dihydro-, dihydrochloride, (-)- Dihydrochloride (-) – 8-Amino-7-chloro- N – [(1,4-diazabicyclo [2.2.2] oct-2-yl) methyl] -2,3-dihydro-1,4-benzodioxin-5 -carboxamide. …

Cimaglermin alfa , GGF2

It’s only fair to share… Cimaglermin alfa , GGF2 RN: 1350717-96-2, UNII: B2A4EZ9I83 CGF-2; GGF-2 – Acorda; Glial growth factor 2 – Acorda; Neuregulin 1 protein; Neuregulin 1β3; NRG1 protein; Recombinant human glial growth factor-2 (rhGGF 2) – Acorda Therapeutics; rhGGF2 – Acorda Treatment of Congestive Heart Failure, rhGGF 2 Molecular Formula, C1747-H2770-N502-O535-S17 (unglycosylated), Molecular Weight, 39923.2958 Glial growth …

Calcifediol, カルシフェジオール

It’s only fair to share… Calcifediol カルシフェジオール Ro 8-8892 U 32070E (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-trien-3,25-diol [German] [ACD/IUPAC Name] (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-triene-3,25-diol [ACD/IUPAC Name] (3S,5Z,7E,20R)-9,10-Sécocholesta-5,7,10-triène-3,25-diol [French] [ACD/IUPAC Name] 19356-17-3 [RN] 1H-indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-a,a,e,7a-tetramethyl-, (eR,1R,3aS,4E,7aR)- 25(OH)D3 25-(OH)Vitamin D3 25-hydroxy Vitamin D3 25-HYDROXYCHOLECALCIFEROL-D6 25-hydroxycholecalciferolmonohydrate 25-hydroxyvitamin D 3-{2-[1-(5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexanol 4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-?,?,?,7a-tetramethyl-(?R,1R,3aS,4E,7aR)-1H-indene-1-pentanol Molecular form.: C₂₇H₄₄O₂ Appearance: White to Off-White Solid Melting Point: 75-93ºC Mol. Weight: 400.64 Calcifediol …

Balsalazide

It’s only fair to share… Balsalazide 80573-04-2; Colazal; Balsalazide Disodium; AC1NSFNR; P80AL8J7ZP; Molecular Formula: C17H15N3O6 Molecular Weight: 357.322 g/mol   (3E)-3-[[4-(2-carboxyethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylic acid  DISODIUMDIHYDRATE CAS Number 150399-21-6 Weight Average: 437.316 Monoisotopic: 437.08110308 Chemical Formula C17H17N3Na2O8 Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the brand names Giazo, …