Category «Uncategorized»

Naloxegol oxalate (MovantikTM, Moventig)

It’s only fair to share… Naloxegol Movantik; NKTR-118; NKTR118; UNII-44T7335BKE; NKTR 118 854601-70-0  cas 1354744-91-4 (Naloxegol Oxalate) (4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol MF C34H53NO11 MW 651.78472 g/mol Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5α,6α)-, ethanedioate (1:1) (salt) Naloxegol oxalate [USAN] UNII-65I14TNM33 AZ-13337019 oxalate Naloxegol (oxalate) NKTR-118 oxalate;AZ-13337019 oxalate UNII:65I14TNM33 Naloxegol oxalate (MovantikTM, Moventig) Naloxegol (INN; PEGylated naloxol;[1] trade names Movantik and Moventig) is …

Opicapone

It’s only fair to share… Opicapone 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine-1-oxide BIA-9-1067; ONO-2370; BIA-91067 CAS No.923287-50-7 MF C15H10Cl2N4O6 MW: 411.9977 TRADE NAME (Ongentys®) Approved EU 2016-06-24 BIAL PORTELA PORTELA & CA. S.A. [PT/PT]; Av. Da Siderurgia Nacional, P-4745-457 S. Mamede do Coronado (PT) LEARMONTH, David Alexander; (PT). KISS, Laszlo Erno; (PT). LEAL PALMA, Pedro Nuno; (PT). DOS SANTOS FERREIRA, Humberto; (PT). …

RPL 554

It’s only fair to share… RPL-554 Molecular FormulaC26H31N5O4 Average mass477.555 RPL 554 Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]- (2-[(2E)-9,10-DIMETHOXY-4-OXO-2-[(2,4,6-TRIMETHYLPHENYL)IMINO]-2H,3H,4H,6H,7H-PYRIMIDO[4,3-A]ISOQUINOLIN-3-YL]ETHYL)UREA 2-[9,10-dimethoxy-4-oxo-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-3-yl]ethylurea {2-[(2E)-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H,3H,4H,6H,7H-pyrimido[4,3-a]isoquinolin-3-yl]ethyl}urea 2-[4-keto-9,10-dimethoxy-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[4,3-a]isoquinolin-3-yl]ethylurea 2-[9,10-dimethoxy-4-oxo-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[4,3-a]isoquinolin-3-yl]ethylurea 298680-25-8  CAS UNII:3E3D8T1GIX CFTR stimulator; PDE 3 inhibitor; PDE 4 inhibitor RPL-554 is a mixed phosphodiesterase (PDE) III/IV inhibitor in phase II clinical development at Verona Pharma for the treatment of asthma, allergic rhinitis, chronic obstructive …

AZD-1236 Revisited

It’s only fair to share… AZD1236 CAS 459814-89-2, MF C15 H19 Cl N4 O5 S.  MW402.85 2,4-Imidazolidinedione, 5-[[[4-[(5-chloro-2-pyridinyl)oxy]-1-piperidinyl]sulfonyl]methyl]-5-methyl-, (5S)- (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione (S)-5-[4-(5-ChIoro-pyridin-2-yloxy)-piperidine-l-suIfonylmethyl]-5-methyl- imidazoIidine-2,4-dione UNII-B4OQY51WZS; B4OQY51WZS; (S)-5-(((4-((5-Chloropyridin-2-yl)oxy)piperidin-1-yl)sulfonyl)methyl)-5-methylimidazolidine-2,4-dione; AZD1236; AZD-1236; Piperidine, 4-[(5-chloro-2-pyridinyl)oxy]-1-[[[(4S)-4-methyl-2,5-dioxo-4-imidazolidinyl]methyl]sulfonyl]- (9CI)(5S)-5-[[[4-[(5-Chloro-2-pyridinyl)oxy]-1-piperidinyl]sulfonyl]methyl]-5-methyl-2,4-imidazolidinedione Mechanism of Action: Matrix metalloproteinase 9 & 12 (MMP9,12) inhibitor MMP9 MMP12i Anders Eriksson, Matti Lepistö, Michael Lundkvist, af Rosenschöld Magnus Munck,Pavol Zlatoidsky, Astrazeneca Ab INNOVATOR …

Osanetant , SR-142,801

It’s only fair to share… Osanetant (SR-142,801) 160492-56-8 CAS : MW 605.257582985 Chemical Formula C35H41Cl2N3O2 (R)-(+)-N-[[3-[1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4-yl]-N-methylacetamide Osanetant (SR-142,801) was a neurokinin 3 receptor antagonist developed by Sanofi-Synthélabo, which was being researched for the treatment of schizophrenia, but was discontinued.[1][2] It was the first non-peptide NK3 antagonist developed in the mid-1990s,[3][4] Other potential applications for osanetant …