It’s only fair to share… BPI-7711, Rezivertinib 1835667-12-3 C27H30N6O3, 486.576 N-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide Beta Pharma in collaboration Chinese licensee CSPC Pharmaceuticals Group , is developing BPI-7711 In June 2021, this drug was reported to be in phase 3 clinical development. OriginatorBeta Pharma ClassAmides; Amines; Antineoplastics; Indoles; Phenyl ethers; Pyrimidines; Small molecules Mechanism of ActionEpidermal growth factor receptor antagonists …
Category «Uncategorized»
Upacicalcet sodium hydrate
It’s only fair to share… Upacicalcet sodium hydrate, ウパシカルセトナトリウム水和物 CAS 2052969-18-1 1333218-50-0 free PMDA JAPAN APPROVED 2021/6/23, Upasita Calcium sensing receptor agonist (2S)-2-amino-3-[(3-chloro-2-methyl-5-sulfophenyl)carbamoylamino]propanoic acid Formula C11H13ClN3O6S. Na. xH2O OriginatorAjinomoto Pharma DeveloperSanwa Kagaku Kenkyusho ClassAmines; Chlorobenzenes; Propionic acids; Small molecules; Sulfonic acids; Toluenes Mechanism of ActionCalcium-sensing receptor agonists RegisteredSecondary hyperparathyroidism 25 Jun 2021Chemical structure information added 23 Jun …
Imeglimin hydrochloride
It’s only fair to share… Meglimin hydrochloride Twymeeg Formula C6H13N5. HCl CAS 775351-61-6 (HCl). , C6H14ClN5 191.66 CAS 775351-65-0, FREEFORM 155.20 Mol weight 191.6619 AntidiabeticAPPROVED PMDA JAPAN2021/6/23, イメグリミン塩酸塩 (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine DB12509 NCGC00378621-02 HY-14771 Q6003719 UNII-UU226QGU97 UU226QGU97 1,3,5-Triazine-2,4-diamine,1,6-dihydro-N,N,6-trimethyl-,(+)-(9CI) (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Imeglimin [INN] Emd 387008 (R-imeglimin) HCl EMD-387008 Imeglimin is an experimental drug being developed as an oral anti-diabetic.[1][2] It is an oxidative phosphorylation blocker that …
CVnCoV, zorecimeran, CureVac COVID-19 vaccine
It’s only fair to share… CVnCoV cas 2541470-90-8 An optimized, non-chemical modified mRNA encoding the prefusion-stabilized full-length spike protein of SARS-CoV-2 virus (Curevac) zorecimeran, CureVac COVID-19 vaccine CureVac/Bayer GSK NCT04674189 NCT04449276 NCT04515147 NCT04652102 EudraCT-2020-004066-19 mRNA-based vaccine PHASE 3 CVnCoV Humoral and cellular responses CD4+ T-cells, CD8+ T-cells N/A N/A Rhesus macaque [124] 124. Rauch S, Gooch …
Tucidinostat, Chidamide
It’s only fair to share… Tucidinostat, Chidamide ツシジノスタット 2021/6/23 PMDA JAPAN APPROVED, Hiyasta Formula C22H19FN4O2 CAS 1616493-44-7 Mol weight 390.4103 Antineoplastic, Histone deacetylase inhibitor Chidamide (Epidaza) is a histone deacetylase inhibitor (HDI) developed in China.[1] It was also known as HBI-8000.[2] It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10.[3] Chidamide is approved by the Chinese FDA for …
Isotretinoin
It’s only fair to share… Isotretinoin Title: Isotretinoin CAS Registry Number: 4759-48-2 CAS Name: 13-cis-Retinoic acid Additional Names: 2-cis-vitamin A acid; neovitamin A acid Manufacturers’ Codes: Ro-4-3780 Trademarks: Accutane (Roche); Isotrex (Stiefel); Oratane (Douglas); Roaccutane (Roche) Molecular Formula: C20H28O2 Molecular Weight: 300.44 Percent Composition: C 79.95%, H 9.39%, O 10.65% Literature References: Naturally occurring metabolite of vitamin A, q.v.; inhibits sebum production. Prepn: C. D. Robeson et …
COVAX-19
It’s only fair to share… Vaxine Pty Ltd company logo Vaxine’s promising new COVID-19 vaccine candidate A new multivalent COVID-19 vaccine developed by Australian company Vaxine to tackle the new virus variants could be game-changer in the fight against COVID-19 The world desperately needs a vaccine that blocks virus transmission and protects against all the …
Uprifosbuvir
It’s only fair to share… Uprifosbuvir MK 3682, IDX 21437 ウプリホスブビル; Formula C22H29ClN3O9P CAS 1496551-77-9 Mol weight 545.9071 уприфосбувир [Russian] [INN] أوبريفوسبوفير [Arabic] [INN] 乌磷布韦 [Chinese] [INN] propan-2-yl (2R)-2-[[[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate Isopropyl (2R)-2-{[(R)-{[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate IDX-21437, DB15206, SB18784, D10996, Q27281714 Uprifosbuvir (MK-3682) is an antiviral drug developed for the treatment of Hepatitis C. It is a nucleotide analogue which acts as an NS5B RNA polymerase inhibitor. It is currently in Phase III human clinical trials.[1][2][3] Uprifosbuvir is under investigation …
ARCT-021 (LUNAR-COV19)
It’s only fair to share… ARCT-021 (LUNAR-COV19) cas 2541451-24-3 A lipid-enabled and UnlockedNucleomonomer Agent modified RNA (LUNAR) of self-replicating RNA for vaccination against spike protein of SARS-CoV-2 (Arcturus) Self-replicating RNA vaccine Arcturus Therapeutics and Duke-NUS Medical School, Singapore OriginatorArcturus Therapeutics ClassCOVID-19 vaccines; RNA vaccines; Viral vaccines Mechanism of ActionImmunostimulants Orphan Drug StatusNo New Molecular EntityNo Available …
DAPAGLIFLOZIN
It’s only fair to share… DAPAGLIFLOZIN, BMS-512148 ダパグリフロジン; (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, Cas 461432-26-8 Molecular Formula: C21H25ClO6 Molecular Weight: 408.87 Dapagliflozin propandiol monohydrate; 960404-48-2 Molecular Weight 502.98 Formula C21H25ClO6•C3H8O2•H2O Bristol-Myers Squibb (Originator) AstraZeneca TYPE 2 DIABETES,SGLT-2 Inhibitors launched 2012, as forxiga in EU, FDA 2014, JAPAN PMDA 2014 Dapagliflozin propanediol monohydrate was first approved by European Medicine Agency (EMA) on November 12, …