It’s only fair to share… Oditrasertib Molecular Formula C14H15F2N3O2 Molecular Weight 295.2846 UNII-I1YQT8HC89 I1YQT8HC89 cas 2252271-93-3 4-(3,3-Difluoro-2,2-dimethylpropanoyl)-3,5-dihydro-2H-pyrido(3,4-F)(1,4)oxazepine-9-carbonitrile PYRIDO(3,4-F)-1,4-OXAZEPINE-9-CARBONITRILE, 4-(3,3-DIFLUORO-2,2-DIMETHYL-1-OXOPROPYL)-2,3,4,5-TETRAHYDRO- Oditrasertib is a serine/threonine kinase (STK) inhibitor. PATENT [WO2018213632A1] https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018213632 AS ON DEC2021 3,491,869 VIEWS ON BLOG WORLDREACH AVAILABLEFOR YOUR ADVERTISEMENT join me on Linkedin Anthony Melvin Crasto Ph.D – India | LinkedIn join me on Researchgate RESEARCHGATE …
Category «Uncategorized»
ORZILOBEN
It’s only fair to share… ORZILOBEN, CAS 1555822-28-0 2-methyl-3-(pentyloxy)benzoic acid Molecular Weight 222.28 Formula C13H18O3 Orziloben is a medium chain fatty acid (MCFA) analogue[1]. Patent WO2020074964 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020074964&_cid=P12-LQYZJX-26404-1 The rising global epidemic of obesity and its comorbidities, e.g., type 2 diabetes mellitus and hyperlipidemia, is placing an enormous burden both on public health (mortality and …
Opevesostat
It’s only fair to share… Opevesostat ODM208 2231294-96-3 Chemical Formula: C21H26N2O5S Molecular Weight: 418.508 2-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-5-{[1-(methanesulfonyl)piperidin-4-yl]methoxy}-4H-pyran-4-one Opevesostat tosylate 2832831-08-8 Molecular Formula C21H26N2O5S.C7H8O3S Molecular Weight 590.71 4H-Pyran-4-one, 2-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-5-[[1-(methylsulfonyl)-4-piperidinyl]methoxy]-, 4-methylbenzenesulfonate (1:1) 2-((1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL)-5-((1-(METHYLSULFONYL)-4-PIPERIDINYL)METHOXY)-4H-PYRAN-4-ONE, TOSYLATE useful in the treatment of a steroid receptor, in particular androgen receptor (AR), dependent conditions and diseases, and to pharmaceutical compositions containing such compounds. Prostate …
Sotuletinib HCl
It’s only fair to share… Sotuletinib HCl CAS: 2222138-31-8 (HCl) Chemical Formula: C20H23ClN4O3S Molecular Weight: 434.939 7W3V82OQ0P Synonym: Sotuletinib HCl; Sotuletinib hydrochloride, Sotuletinib monohydrochloride, BLZ945; BLZ 945; BLZ-945; IUPAC/Chemical Name: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide hydrochloride 2-PYRIDINECARBOXAMIDE, 4-((2-(((1R,2R)-2-HYDROXYCYCLOHEXYL)AMINO)-6-BENZOTHIAZOLYL)OXY)-N-METHYL- Sotuletinib, also known as BLZ945, is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating …
TACACICLIB, AUR-102, AURIGENE
It’s only fair to share… Tacaciclib 2768774-66-7 AUR-102 Tacaciclib SCHEMBL24548621 GTPL12880 528.6 g/mol C30H36N6O3 INN 12755 UNI D3G4JKK1MA (2S)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-methyl-2-[3-[6-[[(E)-4-morpholin-4-ylbut-2-enoyl]amino]pyridin-3-yl]phenyl]butanamide (αS)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]benzeneacetamide Benzeneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]-, (αS)- Tacaciclib is a CDK inhibitor, antineoplastic effect. The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or …
CAREBASTINE
It’s only fair to share… CAREBASTINE Molecular Weight 499.64 Appearance Solid Formula C32H37NO4 CAS No. 90729-42-3 Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of macrophage migration inhibitory factor. Carebastine is the active metabolite …
VODOBATINIB
It’s only fair to share… VODOBATINIB 1388803-90-4 Molecular Weight 453.92 Appearance Solid Formula C27H20ClN3O2 SCO-088 K0706 K-0706 2-chloro-6-methyl-N‘-[4-methyl-3-(2-quinolin-3-ylethynyl)benzoyl]benzohydrazide Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic …
Etrasimod
It’s only fair to share… Etrasimod APD334 C26H26F3NO3 457.493 1206123-37-6 2-[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic acid Etrasimod arginine MXE5EMA09L 1206123-97-8 GVPVVOSNDUAUKM-BPGOJFKZSA-N Name: Etrasimod arginine CAS#: 1206123-97-8 (arginine) Chemical Formula: C32H40F3N5O5 Exact Mass: 631.30 Molecular Weight: 631.700 FDA APPROVED, To treat moderately to severely active ulcerative colitis in adults, 10/12/2023 Velsipity Etrasimod, sold under the brand name Velsipity, is a medication that …
Evobrutinib
It’s only fair to share… Evobrutinib 429.5 g/mol,C25H27N5O2 Evobrutinib 1415823-73-2 Evobrutinib [INN] 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one MSC2364447C MSC2364447C M-2951 MSC-2364447C ZA45457L1K 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one M2951 Evobrutinib is under investigation in clinical trial NCT03934502 (Effect of Meal Composition and Timing on Evobrutinib Bioavailability). Evobrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, evobrutinib inhibits the activity of …
MAVORIXAFOR
It’s only fair to share… MAVORIXAFOR AMD 070 N1-(1H-BENZIMIDAZOL-2-YLMETHYL)-N1-((S)-5,6,7,8-TETRAHYDROQUINOLIN-8-YL)-BUTANE-1,4-DIAMINE Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Molecular Weight 349.47 Appearance Solid Formula C21H27N5 CAS No. …