It’s only fair to share… New Website goflow.at online! C. Oliver Kappe Professor at University of Graz Institute of Chemistry Univ.-Prof. Mag. Dr.rer.nat. +43 316 380-5352 +43 (0) 316 380 – 9840 Oliver.kappe (at) uni-graz.at Research in the Kappe lab focuses on flow chemistry, microreactor technology, process intensification and the continuous generation of active pharmaceutical ingredients …
Darifenacin Hydrobromide, 臭化水素酸ダリフェナシン
It’s only fair to share… Darifenacin 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide Darifenacin; Emselex; Enablex; CAS 133099-04-4; UNII-APG9819VLM; US 2004-12-22 APPROVED EU 2004-10-22 APPROVED Molecular Formula: C28H30N2O2 Molecular Weight: 426.56 g/mol Title: Darifenacin CAS Registry Number: 133099-04-4 CAS Name: (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a,a-diphenyl-3-pyrrolidineacetamide Additional Names: 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine; (S)-2-[1-[2-(2,3,-dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide Manufacturers’ Codes: UK-88525 Molecular Formula: C28H30N2O2 Molecular Weight: 426.55 Percent Composition: C 78.84%, H 7.09%, N 6.57%, O …
MK 0633, SETILEUTON
It’s only fair to share… MK 0633, SETILEUTON (-)-enantiomer 910656-27-8 CAS free form MW 463.3817, C22 H17 F4 N3 O4 FREE FORM Tosylate cas 1137737-87-1 2H-1-Benzopyran-2-one, 4-(4-fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]- 4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one WO2006099735A1 Inventors Thiadiazole substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitor WO 2006099735 A1Marc Blouin, Erich L. Grimm, Yves Gareau, Marc Gagnon, Helene Juteau, Sebastien Laliberte, Bruce …
Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts
It’s only fair to share… Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts Green Chem., 2017, 19,809-815 DOI: 10.1039/C6GC03141B, Paper Haigen Huang, Xueguang Wang, Xu Li, Chenju Chen, Xiujing Zou, Weizhong Ding, Xionggang Lu A non-noble Ni-MoO3/CN@SBA-15 catalyst exhibits unprecedented catalytic activity and chemoselectivity for the reduction of nitroarenes to anilines in …
Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature
It’s only fair to share… Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03494B, Paper Zheng Fang, Wen-Li Hu, De-Yong Liu, Chu-Yi Yu, Xiang-Guo Hu A procedure for the synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions has been developed. Synthesis of tetrazines from gem-difluoroalkenes under …
Photobiocatalytic alcohol oxidation using LED light sources
It’s only fair to share… Photobiocatalytic alcohol oxidation using LED light sources Oxidative lactonization of meso-3-methyl-1,5-pentanediol to (S)-4-methyltetrahydro-2H-pyran-2-one using horse liver alcohol dehydrogenase (HLADH) and photocatalytic, aerobic regeneration of NAD+. Green Chem., 2017, 19,376-379 DOI: 10.1039/C6GC02008A, Communication Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. M. Rauch, S. …
Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation
It’s only fair to share… Fig. 3 Stereoselectivities of the new ApPDC-variants for the synthesis of (S)-PAC. The different variants were tested as wet cells, crude cell extracts, and purified enzymes. Reaction conditions: wet cells – 20 mM benzaldehyde; 200 mM pyruvate; 50 mM KPi-buffer (pH 6.5), 2.5 mM MgSO4; 0.1 mM ThDP; 20 …
New Patent, (S)-pregabalin, WO 2017019791, Teva
It’s only fair to share… Synthesis of (S)-pregabalin, Teva WO-2017019791 TEVA PHARMACEUTICALS INTERNATIONAL GMBH [CH/CH]; Schusselstrasse 12 8645 Jona (CH) (For All Designated States Except US). JANAGANI, Satyanarayana [US/US]; (US) (US only) Improved process for preparing (S)-pregabalin, useful for treating pain, seizures, convulsions and anxiety. Also claims novel intermediates of (S)-pregabalin and their preparation method. …
New Patent, Suzhou MiracPharma Technology Co Ltd, Brigatinib, WO 2017016410
It’s only fair to share… New Patent, Suzhou MiracPharma Technology Co Ltd, Brigatinib, WO 2017016410 WO-2017016410 Preparation method for antitumor drug AP26113 Suzhou MiracPharma Technology Co Ltd SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD [CN/CN]; Room 1305, Building 1,Lianfeng Commercial Plaza, Industrial District Suzhou, Jiangsu 215000 (CN) XU, Xuenong; (CN) Improved process for preparing brigatinib, useful for treating cancer …
1 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-4-ol)
It’s only fair to share… 1 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-4-ol) Examples Example 1 – Preparation Of Compound 1 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-4-ol) 4-(3-(methylthio)phenyl)-1 – 4-(3-(methylsulfonyl)phenyl)- propylpiperidin-4-ol 1 -propylpiperidin-4-ol To a suspension of 4-hydroxy-4-(3-(methylthio)phenyl)-l-propylpiperidin-l-ium chloride (140g, 348mmol) in 710mL water were added 1.5g sodium tungstate dihydrate, and the mixture was heated to 45°C. 102mL of 33%H202 were added in 20min at 45-55°C. …