It’s only fair to share… Gamcemetinib CAS 1887069-10-4 CC-99677 , OS2IR8TV1O Molecular Weight 469.94 Formula C22H20ClN5O3S (R)-3-((2-Chloro-5-(ethoxymethyl)pyrimidin-4-yl)oxy)-10-methyl-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-f]quinolin-8-one Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1. SCHEME …
Alflutinib, Furmonertinib, Firmonertinib
It’s only fair to share… FIRMOMERTINIB, Furmonertinib, Alflutinib CAS 1869057-83-9 , AST 2818, UNII-A49A7A5YN4 N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-2-propenamide N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]prop-2-enamide C28H31F3N8O2 568.6 g/mol 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]- Alflutinib is under investigation in clinical trial NCT03452592 (Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients With T790M). Firmonertinib is an orally available selective inhibitor of the epidermal growth …
Lotilaner
It’s only fair to share… Lotilaner 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide FDA Xdemvy, 7/25/2023, To treat Demodex blepharitisDrug Trials Snapshot Lotilaner, sold under the brand name Xdemvy, is an ectoparasiticide (anti-parasitic) medication used for the treatment of blepharitis (inflammation of the eyelid) caused by infestation by Demodex (tiny mites).[1][7] It is used as an eye drop.[1] It was approved for medical use in the United States in July 2023.[1][7][8][9] The US Food …
Fexagratinib
It’s only fair to share… Fexagratinib AZD 4547; ADSK091 cas 1035270-39-3 WeightAverage: 463.582Monoisotopic: 463.258339943 Chemical FormulaC26H33N5O3 N-(5-(2-(3,5-DIMETHOXYPHENYL)ETHYL)-1H-PYRAZOL-3-YL)-4-((3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL)BENZAMIDE N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide Fexagratinib (AZD4547) is an experimental drug which acts as an inhibitor of the fibroblast growth factor receptors, having high affinity for FGFR1, FGFR2 and FGFR3 and weaker activity at FGFR4. It has reached clinical trials in humans against several forms of cancer, …
ETRIPAMIL
It’s only fair to share… ETRIPAMIL CAS 1593673-23-4 AS ACETATE 512.64 CAS 2891832-59-8 HCL SALT 2560549-35-9 WeightAverage: 452.595Monoisotopic: 452.267507647 Chemical FormulaC27H36N2O4 Benzoic acid, 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]-, methyl ester methyl 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-methylamino]ethyl]benzoate Etripamil has been used in trials studying the treatment of Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium …
Ervogastat
It’s only fair to share… Ervogastat CAS 2186700-33-2 Non-alcoholic Steatohepatitis (NASH) with Liver Fibrosis (FAST TRACK – U.S.) 2-[5-(3-ethoxypyridin-2-yl)oxypyridin-3-yl]-N-[(3S)-oxolan-3-yl]pyrimidine-5-carboxamide Phase IINon-alcoholic fatty liver disease; Non-alcoholic steatohepatitis Ervogastat is an experimental small-molecule drug and selective diacylglycerol O-acyltransferase 2 inhibitor developed by Pfizer for non-alcoholic steatohepatitis.[1] Its development was previously halted by the company but resumed in 2022.[2] Scheme SIDE CHAIN MAIN https://doi.org/10.1021/acs.jmedchem.2c01200 SYN …
Flotufolastat F 18
It’s only fair to share… Flotufolastat F 18 gallium;2-[7-[(1S)-1-carboxy-4-[[(2R)-1-[[(1R)-1-carboxy-5-[[4-[[(4R)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(1S)-1,3-dicarboxypropyl]carbamoylamino]butanoyl]amino]butyl]amino]-4-oxobutanoyl]amino]pentyl]amino]-3-[[4-[ditert-butyl(fluoranyl)silyl]benzoyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutyl]-4,10-bis(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate WeightAverage: 1470.63Monoisotopic: 1469.662295938 Chemical FormulaC63H99FN12O25Si 2639294-14-5 CAS FDA 2023, Posluma, 5/25/2023, To use with positron emission tomography imaging in certain patients with prostate cancerDrug Trials Snapshot Flotufolastat (18F), sold under the brand name Posluma, is a radioactive diagnostic agent for use with positron emission tomography (PET) imaging for prostate cancer.[1] The active ingredient is flotufolastat …
ELUBIOL
It’s only fair to share… ELUBIOL Dichlorophenyl imidazoldioxolan CAS 67914-69-6 AMY 925C27H30Cl2N4O5, 561.5 g/mol ethyl 4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-1-carboxylate Elubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff. SCHEME PATENT DE2804096 https://patentscope.wipo.int/search/en/detail.jsf?docId=DE102084041&_cid=P20-MB323Q-91006-1 PATENT US4358449 https://patentscope.wipo.int/search/en/detail.jsf?docId=US37288536&_cid=P20-MB3265-92366-1 PATENT CN102070620 https://patentscope.wipo.int/search/en/detail.jsf?docId=CN84648943&_cid=P20-MB329Q-94515-1 Example 1 According to the method of the present invention, bacteriostatic …
Elfucose
It’s only fair to share… Elfucose Cas 87-96-7 Chemical Formula: C6H12O5Exact Mass: 164.07Molecular Weight: 164.157 L-fucopyranose (6-deoxy-L-galactopyranose) (3S,4R,5S,6S)-6-methyloxane-2,3,4,5-tetrol Fucose is under investigation in clinical trial NCT03354533 (Study of ORL-1F (L-fucose) in Patients With Leukocyte Adhesion Deficiency Type II). L-fucopyranose is the pyranose form of L-fucose. It has a role as an Escherichia coli metabolite and …
Durlobactam
It’s only fair to share… Durlobactam CAS 1467829-71-5 WeightAverage: 277.25Monoisotopic: 277.03685626 Chemical FormulaC8H11N3O6S Ingredient UNII CAS InChI Key Durlobactam sodium F78MDZ9CW9 1467157-21-6 WHHNOICWPZIYKI-IBTYICNHSA-M FDA 5/23/2023, Xacduro, To treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complexPress ReleaseDrug Trials Snapshots (2S,5R)-2-CARBAMOYL-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL SULFATE SULFURIC ACID, MONO((2S,5R)-2-(AMINOCARBONYL)-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL) ESTERETX 2514, ETX-2514, ETX2514, WHO …