It’s only fair to share… Edelinontrine CRD740, PF04447943, cas 1082744-20-4 Molecular Weight 395.46 Formula C20H25N7O2 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM). PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and …
Sulbactam
It’s only fair to share… Sulbactam Ingredient UNII CAS InChI Key Sulbactam benzathine 49MU89FVBV 83031-43-0 YSEPFTSCLHUBNH-HFKSPEPWSA-N Sulbactam sodium DKQ4T82YE6 69388-84-7 NKZMPZCWBSWAOX-IBTYICNHSA-M 68373-14-8 (free acid) WeightAverage: 233.242Monoisotopic: 233.035793157 Chemical FormulaC8H11NO5S (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Betamaze, Penicillanic Acid Sulfone, Sulbactamum, CP 45899, CP-45899, CP45899 FDA 2023, Xacduro, 5/23/2023, To treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by …
Eclitasertib
It’s only fair to share… Eclitasertib CAS 2125450-76-0 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide Molecular Weight 378.38 Formula C19H18N6O3 SAR443122, was investigated in several clinical trials to evaluate its safety and efficacy. NCT04469621 was studied in severe COVID-19 patients, while NCT05588843 is currently recruiting participants with ulcerative colitis. Additionally, NCT04781816, which was completed with results, focused on patients with cutaneous …
Perfluorhexyloctane
It’s only fair to share… WeightAverage: 432.269Monoisotopic: 432.112266666Chemical FormulaC14H17F13 Perfluorhexyloctane 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorotetradecane FDA APPROVED 8/16/2023, Sohonos, To reduce the volume of new heterotopic ossification in adults and pediatric patients (aged 8 years and older for females and 10 years and older for males) with fibrodysplasia ossificans progressivaDrug Trials Snapshot Perfluorohexyloctane is a fluoroalkane that is tetradecane in which …
DIMDAZENIL
It’s only fair to share… DIMDAZENIL CAS 308239-86-3 WeightAverage: 372.81Monoisotopic: 372.1101515 Chemical FormulaC17H17ClN6O2 EVT-201, 308239-86-3, EVT201, 6J8AF7CLE4, EVT 201 7-Chloro-3-[5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl]-4,5-dihydro-5-methyl-6H-imidazo[1,5-a] [1,4]benzodiazepin-6-one 7-chloro-3-[5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl]-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one EVT 201 is a novel partial positive allosteric modulator of the GABAA receptor complex which is being developed as a treatment for insomnia. It is being developed by Evotec Inc. Dimdazenil, sold under …
Digadoglucitol
It’s only fair to share… Digadoglucitol DA-52534 CAS 2098944-37-5 μ-[2,2′,2”,2”’,2””,2””’-({[(2S,3R,4R,5R)-2,3,4,5,6- pentahydroxyhexyl]azanediyl}bis{[2-(hydroxy-κO)propane3,1-diyl]-1,4,7,10-tetraazacyclododecane-10,1,4,7-tetraylκ4 N1 ,N4 ,N7 ,N10})hexa(acetato-κO)]digadolinium diagnostic agent C40H69Gd2N9O19 MW 1,294.536 F2Q2ZU6CAU SCHEME PATENT Bracco Imaging SpA WO2017098044 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017098044&_cid=P12-MAUH6W-49653-1 PATENT WO2023006722 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2023006722&_cid=P12-MAUHGF-56290-1 PATENT WO2022023240 .///////////Digadoglucitol, F2Q2ZU6CAU, X RAY CONTRAST AGENT, DA-52534, DA 52534 It’s only fair to share…
Tofersen
It’s only fair to share… all-P-ambo-2′-O-(2-Methoxyethyl)-5-methyl-P-thiocytidylyl-(3’→5′)-2′-O-(2-methoxyethyl)adenylyl-(3’→5′)-2′-O-(2-methoxyethyl)-P-thioguanylyl-(3’→5′)-2′-O-(2-methoxyethyl)guanylyl-(3’→5′)-2′-O-(2-methoxyethyl)-P-thioadenylyl-(3’→5′)-P-thiothymidylyl-(3’→5′)-2′-deoxy-P-thioadenylyl-(3’→5′)-2′-deoxy-5-methyl-P-thiocytidylyl-(3’→5′)-2′-deoxy-P-thioadenylyl-(3’→5′)-P-thiothymidylyl-(3’→5′)-P-thiothymidylyl-(3’→5′)-P-thiothymidylyl-(3’→5′)-2′-deoxy-5-methyl-P-thiocytidylyl-(3’→5′)-P-thiothymidylyl-(3’→5′)-2′-deoxy-P-thioadenylyl-(3’→5′)-2′-O-(2-methoxyethyl)-5-methylcytidylyl-(3’→5′)-2′-O-(2-methoxyethyl)-P-thioadenylyl-(3’→5′)-2′-O-(2-methoxyethyl)guanylyl-(3’→5′)-2′-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3’→5′)-2′-O-(2-methoxyethyl)-5-methyluridine C230H317N72O123P19S15 : 7127.86[2088232-70-4] Tofersen CAS 2088232-70-4 FDA APPROVED 4/25/2023, Qalsody To treat amyotrophic lateral sclerosis in adults who have a SOD1 gene mutationDrug Trials Snapshot A nucleic acid-based drug indicated for the treatment of a specific type of amyotrophic lateral sclerosis. Tofersen, sold under the brand name Qalsody, is a medication used for the …
Deupsilocin
It’s only fair to share… Deupsilocin, Psilocin-d10 Molecular Formula C12H16N2O Molecular Weight 214.3299 KXD3HS8D6X CAS 1435934-64-7 3-[2-[Di(methyl-d3)amino]ethyl-1,1,2,2–d4]-1H-indol-4-ol 3-[2-[bis(trideuteriomethyl)amino]-1,1,2,2-tetradeuterioethyl]-1H-indol-4-ol 1H-Indol-4-ol, 3-[2-[di(methyl-d3)amino]ethyl-1,1,2,2-d4]- Mental health disorders, or mental illness, refer to a wide range of disorders that include, but are not limited to, depressive disorders, anxiety and panic disorders, schizophrenia, eating disorders, substance misuse disorders, post-traumatic stress disorder, …
Demannose
It’s only fair to share… Demannose CAS 530-26-7, 3458-28-4 180.16 g/mol D-mannopyranose congenital glycosylation disorders D-mannopyranose is d-Mannose in its six-membered ring form. It has a role as a metabolite. It is a D-aldohexose, a D-mannose and a mannopyranose. SCHEME LIT Tetrahedron Letters (1987), 28(31), 3569-72 ///////////Demannose, D-Mannopyranose, Carubinose, Seminose, mannopyranose It’s only fair to share…
Leniolisib
It’s only fair to share… Leniolisib CAS 1354690-24-6 WeightAverage: 450.466Monoisotopic: 450.199108558 Chemical FormulaC21H25F3N6O2 1-[(3S)-3-({6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-4-yl}amino)pyrrolidin-1-yl]propan-1-one FDA APPROVED Joenja, 3/24/2023, To treat activated phosphoinositide 3-kinase delta syndromeDrug Trials Snapshot Leniolisib (INN[3][4]), sold under the brand name Joenja, is a medication used for the treatment of activated phosphoinositide 3-kinase delta syndrome (APDS).[2][5] It is a kinase inhibitor[2][6] that is taken by mouth.[2] The most common side effects …