OLODATEROL, オロダテロール

It’s only fair to share… FDA Approves Striverdi Respimat to Treat Chronic Obstructive Pulmonary Disease July 31, 2014 — Today, the U.S. Food and Drug Administration approved Striverdi Respimat (olodaterol) inhalation spray to treat patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema that are experiencing airflow obstruction. Striverdi Respimat can be …

Fidaxomicin, フィダキソマイシン

It’s only fair to share…     Fidaxomicin (C52H74Cl2O18, Mr = 1058.0 g/mol) Launched – 2011 MERCK, Clostridium difficile-associated diarrhea CUBIST ….INNOVATOR OPT-80 PAR-101 Also tiacumicin B or lipiarmycin A3, A bacterial RNA polymerase inhibitor as macrocyclic antibiotic used to treat clostridium difficile-associated diarrhea (CDAD). SYNTHESIS REFERENCES US 4918174 WO 2006085838 J ANTIBIOTICS 1987, 40, PG …

GDC 0853, Fenebrutinib

It’s only fair to share…   . Picture credit….Bethany Halford GDC 0853, Fenebrutinib GDC-0853; RG 7845 Molecular Formula: C37H44N8O4 Molecular Weight: 664.79646 g/mol 2-[3-(hydroxymethyl)-4-[1-methyl-5-[(7-methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-3-pyridyl]-2-pyridyl]-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1-one 3-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-[2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl]amino]-6-oxopyridin-3-yl]pyridin-2-yl]-7,7-dimethyl-1,2,6,8-tetrahydrocyclopenta[3,4]pyrrolo[3,5-b]pyrazin-4-one 3-[3-(hydroxymethyl)-4-[5-[[5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]-2-pyridyl]amino]-6-oxo-1H-pyridin-3-yl]-2-pyridyl]-7,7-dimethyl-1,2,6,8-tetrahydrocyclopenta[3,4]pyrrolo[3,5-b]pyrazin-4-one 2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, 2-[1,6-dihydro-3′-(hydroxymethyl)-1-methyl-5-[[5-[(2S) -2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino] -6-oxo[3,4′-bipyridin]-2′-yl]-3,4,7,8-tetrahydro-7,7- dimethyl- s ISoMER 1434048-34-6 desired r iSoMER 1434048-57-3 undesired   Phase 1 Patients with Patients with Resistant B-Cell Lymphoma or Chronic Lymphocytic Leukemia.. @genentech‘s Btk inhibitor https://clinicaltrials.gov/ct2/show/NCT01991184 Bruton tyrosine …

TAFENOQUINE, タフェノキン

It’s only fair to share… Tafenoquine タフェノキン N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine 1,4-Pentanediamine, N4-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]- 106635-80-7 [RN] 262P8GS9L9 7835 N4-{2,6-Dimethoxy-4-methyl-5-[3-(trifluormethyl)phenoxy]-8-chinolinyl}-1,4-pentandiamin WR-238605, WR 238605, cas no 106635-80-7, Tafenoquine succinate, Etaquine, SB-252263, WR-238605 N(4)-(2,6-Dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine Molecular Formula: C24H28F3N3O3 Molecular Weight: 463.49263 Medicines for Malaria Venture Walter Reed Army Institute (Originator) PATENT  US 4617394 Synonyms Etaquine[5] WR 238605 [5] SB-252263 New Drug Application (NDA): 210795 Company: GLAXOSMITHKLINE FDA approved on July 20, 2018 FDA …

Umeclidinium bromide, ウメクリジニウム臭化物

It’s only fair to share…   Umeclidinium bromide GSK-573719A, ウメクリジニウム臭化物 Molecular FormulaC29H34BrNO2 Average mass508.490 Da 1-[2-(Benzyloxy)ethyl]-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide 1-Azoniabicyclo[2.2.2]octane, 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-, bromide (1:1) diphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol;bromide 7AN603V4JV 869113-09-7 [RN] 9551 GSK573719A; UNII-7AN603V4JV Umeclidinium bromide (trade name Incruse Ellipta) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).[1] It is also approved for this indication in combination with vilanterol (as umeclidinium bromide/vilanterol).[2][3] In the 2014, …

Ivosidenib,  ивосидениб , إيفوزيدينيب , 艾伏尼布 , 

It’s only fair to share… Ivosidenib AG-120; TIBSOVO FDA approves first targeted treatment Tibsovo (ivosidenib) for patients with relapsed or refractory acute myeloid leukemia who have a certain genetic mutation The U.S. Food and Drug Administration today approved Tibsovo (ivosidenib) tablets for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) …

Vilanterol trifenatate, ビランテロールトリフェニル酢酸塩

It’s only fair to share…   Vilanterol trifenatate, ビランテロールトリフェニル酢酸塩 ビランテロールトリフェナテート UNII-40AHO2C6DG; GW642444M; CAS 503070-58-4 free form, 503068-34-6 HY-14300A, CS-1679 444 642444 GSK-642444 GW-642444 GW-642444M 4-[(1R)-2-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol;2,2,2-triphenylacetic acid 1,3-Benzenedimethanol, α1-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-, (α1R)- 4-{(1R)-2-[(6-{2-[(2,6-Dichlorbenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol Molecular Formula: C44H49Cl2NO7 Molecular Weight: 774.776 g/mol 4-[(1R)-2-({6-[(2-{[(2,6-Dichlorophenyl)methyl]oxy}ethyl)oxy]hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol Acetate Salt J. Med. Chem., 2010, 53 (11), pp 4522–4530 DOI: 10.1021/jm100326d white crystalline solid: mp (DSC) 131.9−134.2 °C, [α]D 20 −14.6 (c 1.034 in MeOH). MS ES …

BMS-978587

It’s only fair to share…   BMS-978587 Molecular Formula: C26H35N3O3 CAS 1629125-65-0 Molecular Weight: 437.582 US9675571   PATENT Inventor James Aaron Balog Audris Huang Bin Chen Libing Chen Steven P. Seitz Amy C. Hart Jay A. Markwalder AssigneeBristol-Myers Squibb Co Priority date 2013-03-15 IDO-IN-4; 1629125-65-0; SCHEMBL17456163; AKOS030526622; ZINC521836543; CS-5086 (1R,2S)-2-[4-(Di-isobutylamino)-3-(3-(p-tolyl)ureido)phenyl] Cyclopropanecarboxylic Acid (1R,2S)-2-[4-[bis(2-methylpropyl)amino]-3-[(4-methylphenyl)carbamoylamino]phenyl]cyclopropane-1-carboxylic acid (lR,2S)-2-(4-(diisobutylamino)-3-(3-(p- tolyl)ureido)phenyl)cyclopropanecarboxylic acid BMS-978587 was discovered and developed within Bristol-Myers Squibb …

YINLITINIB

It’s only fair to share…   YINLITINIB error EMAIL ME amcrasto@gmail.com (E)-4-[(4aR,7aS)-2,3,4a,5,7,7a-hexahydro-[1,4]dioxino[2,3-c]pyrrol-6-yl]-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]but-2-enamide (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-((4aR,7aS)-tetrahydro-2H-[1,4]dioxin[2,3-c]pyrrol-6(3H)-yl)but-2-enamide CAS 1637253-79-2 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel– C25 H25 Cl F N5 O4, 513.95 DNT-04110 ; yinlitinib maleate , Guangdong Hec Pharmaceutical Use for treating proliferative diseases, atherosclerosis and pulmonary fibrosis Phase I CHINA NOTE AND USE YOUR JUDGMENT ON DRUG SUBSTANCE, EMAIL ME amcrasto@gmail.com Molecular Formula: C25H25ClFN5O4 Molecular Weight: …

Carglumic acid, карглумовая кислота , حمض كاروغلوميك , カルグルミ酸 ,

It’s only fair to share…   Carglumic acid N-Carbamyl-L-glutamate; Molecular FormulaC6H10N2O5 Average mass190.154 Da N-Carbamylglutamate карглумовая кислота [Russian] [INN] حمض كاروغلوميك [Arabic] [INN] カルグルミ酸; 1188-38-1 [RN] 5L0HB4V1EW 8008 L-Glutamic acid, N-(aminocarbonyl)- L-Glutamic acid, N-(hydroxyiminomethyl)- N-[Hydroxy(imino)methyl]-L-glutamic acid (S)-2-Ureidopentanedioic acid (S)-2-ureidopentanedioic acid; N-Carbamoyl-L-Glutamic Acid; N-Carbamyl-L-glutamate; N-Carbamylglutamate OE 312 / OE-312, UNII5L0HB4V1EW Prepn: H. McIlwain, Biochem. J. 33, 1942 (1939) Carglumic acid is a Carbamoyl Phosphate Synthetase 1 Activator. The mechanism …