Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions

It’s only fair to share…   Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions Green Chem., 2017, 19,2931-2935 DOI: 10.1039/C7GC00789B, Communication O. N. Chupakhin, A. V. Shchepochkin, V. N. Charushin A simple and efficient electrochemical method for the synthesis of asymmetrical bi(het)aryls through direct functionalization of the C(sp2)-H bond in …

Increasing global access to the high-volume HIV drug nevirapine through process intensification

It’s only fair to share…   Increasing global access to the high-volume HIV drug nevirapine through process intensification Green Chem., 2017, 19,2986-2991 DOI: 10.1039/C7GC00937B, Paper Jenson Verghese, Caleb J. Kong, Daniel Rivalti, Eric C. Yu, Rudy Krack, Jesus Alcazar, Julie B. Manley, D. Tyler McQuade, Saeed Ahmad, Katherine Belecki, B. Frank Gupton Fundamental elements of process …

Cp2TiCl: An Ideal Reagent for Green Chemistry?

It’s only fair to share…     The development of Green Chemistry inevitably involves the development of green reagents. In this review, we highlight that Cp2TiCl is a reagent widely used in radical and organometallic chemistry, which shows, if not all, at least some of the 12 principles summarized for Green Chemistry, such as waste …

One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

It’s only fair to share…   One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone Green Chem., 2017, Advance Article DOI: 10.1039/C7GC00578D, Communication Lei Song, Mingyuan Zheng, Jifeng Pang, Joby Sebastian, Wentao Wang, Minjie Qu, Jian Zhao, Xinhong Wang, Tao Zhang An efficient and environmentally benign method for the synthesis of 2-hydroxymethyl-5-methylpyrazine (HMMP) from biomass derived 1,3-dihydroxyacetone …

Imigliptin dihydrochloride, Xuanzhu Pharma Co Ltd, NEW PATENT, WO 2017107945

It’s only fair to share…   Imigliptin dihydrochloride, Xuanzhu Pharma Co Ltd, NEW PATENT, WO 2017107945 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017107945&redirectedID=true Applicants: XUANZHU PHARMA CO.,LTD. [CN/CN]; 2518, Tianchen Street, National High-tech Development Zone Jinan, Shandong 250101 (CN) Inventors: SHU, Chutian; (CN). WANG, Zhenhua; (CN) The present invention relates to a crystalline form of benzoate of a dipeptidyl peptidase-IV inhibitor, a method for preparing …

Lisdexamphetamine

It’s only fair to share… Lisdexamfetamine Molecular FormulaC15H25N3O Average mass263.379 Da 608137-32-2 [RN] Elvanse [Trade name] Hexanamide, 2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-, (2S)- Lisdexamfetamine L-lysine-d-amphetamine (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanimidic acid H645GUL8KJ L-lysine-(+)-amphetamine NRP104|Vyvanse® UNII:H645GUL8KJ UNII-H645GUL8KJ Vyvanse® CAS 608137-33-3 (2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide dimethanesulfonate https://www.google.com/patents/WO2005032474A2 Applicants: NEW RIVER PHARMACEUTICALS INC. [US/US]; The Governor Tyler, 1881 Grove Avenue, Radford, VA 24141 (US) (For All Designated States Except US). …

Green Synthesis of Veratraldehyde Using Potassium Promoted Lanthanum–Magnesium Mixed Oxide Catalyst

It’s only fair to share…   Veratraldehyde is an important chemical used in perfumery, agrochemical, and pharmaceutical industries. Current processes of manufacture of veratraldehyde use homogeneous catalysts, which make them highly polluting, creating problems of disposal of effluents and product purity. In the current work, veratraldehyde was synthesized from O-alkylation of vanillin with an environmentally …

FDA approves first subcutaneous C1 Esterase Inhibitor to treat rare genetic disease

It’s only fair to share… FDA approves first subcutaneous C1 Esterase Inhibitor to treat rare genetic disease 06/22/2017   The U.S. Food and Drug Administration today approved Haegarda, the first C1 Esterase Inhibitor (Human) for subcutaneous (under the skin) administration to prevent Hereditary Angioedema (HAE) attacks in adolescent and adult patients. The subcutaneous route of …

Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

It’s only fair to share…   Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01289F, Paper Zhanhui Yang, Zhongpeng Zhu, Renshi Luo, Xiang Qiu, Ji-tian Liu, Jing-Kui Yang, Weiping Tang A highly efficient iridium catalyst is developed for the chemoselective reduction …