DESLORATADINE, デスロラタジン

It’s only fair to share… Desloratadine Molecular FormulaC19H19ClN2 Average mass310.821 Da 100643-71-8 [RN] 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)- 7817 Desloratadine, Descarboethoxyloratadine, Sch-34117, DCL, Denosin, Clarinex RediTabs, Allex, Desalex, Opulis, Clarinex, Neoclarityn, Aerius, MK-4117 Desloratadine (trade name Clarinex and Aerius) is a tricyclic H1-antihistamine that is used to treat allergies. It is an active metaboliteof loratadine. It was patented in 1984 and came into medical use in 2001.[1] Medical uses …

CMX-8521, CMX-521

It’s only fair to share… CMX-8521, CMX-521 MF C13 H17 N5 O5,  MW 323.30 CAS Number 2077178-99-3 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-2-methyl-7-β-D-ribofuranosyl- Nucleoside analogs (oral, norovirus infection), Chimerix 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methylpyrrolo[2,3-d]pyrimidine-5-carboxamide CMX8521 is a nucleoside analog that inhibits the norovirus RNA polymerase. CMX8521 has in vitro activity against mouse and human norovirus.Where possible, Chimerix uses its lipid conjugate technology to build nucleoside-analog antivirals that …

RISDIPLAM , リスジプラム

It’s only fair to share… RISDIPLAM RG-7916, RO-7034067, リスジプラム Formula C22H23N7O Cas 1825352-65-5 Mol weight 401.4643 US9969754 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one   WHO 10614 RG-7916 HY-109101 RO7034067 CS-0039501 EX-A2074 RG7916 The compound was originally claimed in WO2015173181 , for treating spinal muscular atrophy (SMA). Roche , under license from PTC Therapeutics , and Chugai , are developing risdiplam (RO-7034067; RG-7916), …

Cladribine, クラドリビン

It’s only fair to share… Cladribine クラドリビン Leustatin クラドリビン RWJ 26251 / RWJ-26251 Molecular FormulaC10H12ClN5O3 Average mass285.687 Da 2-chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine 2-Chlorodeoxyadenosine 4291-63-8 [RN] 6997 adenosine, 2-chloro-2′-deoxy- [ACD/Index Name] AU7357560 CDA (2R,3S,5R)-5-(6-Amino-2-chlor-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol Leustatin (Trade name) Litak (Trade name) MLS000759397 Movectro (Trade name) Mylinax QA-1968 LAUNCHED, 1993, USA Ortho Biotech, Janssen Biotech Cladribine, sold under the brand name Leustatin and Mavenclad among others, is a medication used to …

E 2212

It’s only fair to share… C25 H23 F3 N6 O, 480.48 CAS 1123197-68-1 (+) -2-{(E)-2-[5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (+)-5,6,7,8-Tetrahydro-2-[(1E)-2-[5-methoxy-6-(4-methyl-1H-imidazol-1-yl)-3-pyridinyl]ethenyl]-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridine (+)-2-[(E)-2-[5-Methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl]ethenyl]-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine   E2212 CAS 1123197-82-9 C25 H23 F3 N6 O . 3/2 C4 H6 O6 [1,2,4]Triazolo[1,5-a]pyridine, 5,6,7,8-tetrahydro-2-[(1E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]ethenyl]-8-[2-(trifluoromethyl)phenyl]-, (8S)-, (2S,3S)-2,3-dihydroxybutanedioate (2:3) PATENT https://patents.google.com/patent/US9453000B2/en Examples 394 and 395 Synthesis of (+) and (−)-2-{(E)-2-[5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine 230 mg of the racemic title compound was obtained from 1-amino-3-(2-trifluoromethylphenyl)piperidin-2-one (343 mg) and (E)-3-[5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl]acrylic acid (500 mg) by the same method …

Certolizumab pegol, セルトリズマブペゴル (遺伝子組換え)

It’s only fair to share… >Amino acid sequence of the light chain DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQQKPGKAPKALIYSASFLYSGVPY RFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPLTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC >Amino acid sequence of the heavy chain EVQLVESGGGLVQPGGSLRLSCAASGYVFTDYGMNWVRQAPGKGLEWMGWINTYIGEPIY ADSVKGRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCARGYRSYAMDYWGQGTLVTVSSAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGL YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCAA Certolizumab pegol CAS: 428863-50-7 セルトリズマブペゴル (遺伝子組換え) CDP 870 / CDP-870 / CDP870 / PHA-738144 Formula C2115H3252N556O673S16 Cas 428863-50-7 Mol weight 47748.8128   Reducing signs and symptoms of Crohn’s disease and treatment of moderately to severely …

Cevimeline, セビメリン

It’s only fair to share…   Cevimeline セビメリン Molecular FormulaC10H17NOS Average mass199.313 Da cis-2′-Methylspiro[4-azabicyclo[2.2.2]octane-2,5′-[1,3]oxathiolane] Evoxac [Trade name] Spiro[1-azabicyclo[2.2.2]octane-3,5′-[1,3]oxathiolane], 2‘-methyl-, (2’R,3R)- Cevimeline CAS Registry Number: 107233-08-9 CAS Name: (2¢R,3R)-rel-2¢-Methylspiro[1-azabicyclo[2.2.2]octane-3,5¢-[1,3]oxathiolane] Additional Names: (±)-cis-2-methylspiro[1,3-oxathiolane-5,3¢-quinuclidine] Molecular Formula: C10H17NOS Molecular Weight: 199.31 Percent Composition: C 60.26%, H 8.60%, N 7.03%, O 8.03%, S 16.09% Literature References: Muscarinic M1 and M3 receptor agonist. Prepn: A. Fisher et al., JP Kokai 61 280497; eidem, US 4855290; (1986, 1989 …

FDA approves new oral testosterone capsule for treatment of men with certain forms of hypogonadism

It’s only fair to share…   FDA approves new oral testosterone capsule (testosterone undecanoate) for treatment of men with certain forms of hypogonadism March 27, 2019 Release The U.S. Food and Drug Administration today approved Jatenzo (testosterone undecanoate), an oral testosterone capsule to treat men with certain forms of hypogonadism. These men have low testosterone …

Batimastat, バチマスタット

It’s only fair to share… Batimastat バチマスタット Formula C23H31N3O4S2 cas 130370-60-4 Mol weight 477.6399 Butanediamide, N4-hydroxy-N1-(2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl)-2-(2-methylpropyl)-3-((2-thienylthio)methyl)-, (2R-(1(S*),2R*,3S*))- DESCARBOXY-NOR-N(ω)-HYDROXY-L-ARGININE DSX EJ6675000 UNII:BK349F52C9 (2R,3S)-N4-Hydroxy-2-isobutyl-N1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-3-[(2-thienylsulfanyl)methyl]succinamide (2R,3S)-N4-hydroxy-N1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-2-(2-methylpropyl)-3-[(thiophen-2-ylsulfanyl)methyl]butanediamide (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide (2S,3R)-5-Methyl-3-(((aS)-a-(methylcarbamoyl)phenethyl)carbamoyl)-2-((2-thienylthio)methyl)hexanohydroxamic Acid [2R-[1(S*),2R*,3S*]]-N4-Hydroxy-N1-[2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butane Diamide 130370-60-4 [RN] 7154 Batimastat [BAN] [INN] [USAN] [Wiki] BK349F52C9 CAS Registry Number: 130370-60-4 CAS Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide Additional Names: (2S,3R)-5-methyl-3-[[(aS)-a-(methylcarbamoyl)phenethyl]carbamoyl]-2-[(2-thienylthio)methyl]hexanohydroxamic acid; [4-(N-hydroxyamino)-2R-isobutyl-3S-(2-thienylthiomethyl)succinyl]-L-phenylalanine-N-methylamide Manufacturers’ Codes: BB-94 Molecular Formula: C23H31N3O4S2 Molecular Weight: 477.64 Percent Composition: C 57.84%, H 6.54%, N 8.80%, O …

TASELISIB

It’s only fair to share…    Molecular FormulaC24H28N8O2 Average mass460.531 Da RG7604,Taselisib GDC-0032, GDC0032;GDC 0032, RO5537381 1282512-48-4 [RN] 1H-Pyrazole-1-acetamide, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl- UNII:L08J2O299M 10.1021/jm4003632 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide NMR http://file.selleckchem.com/downloads/nmr/s710301-gdc-0032-hnmr-selleck.pdf POLYMORPHS almost A to Z, US9266903 Taselisib (GDC-0032) is an experimental cancer drug in development by Roche. Molecule is a complex heterocycle with no chiral centres, hazardous materials are used in synthesis, preparation …