A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug

It’s only fair to share…       PAPER HETEROCYCLES An International Journal for Reviews and Communications in Heterocyclic Chemistry Web Edition ISSN: 1881-0942 Published online: 11th October, 2016 Paper | Regular issue | Prepress DOI: 10.3987/COM-16-13538 ■ A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug Zhezhou Yang, Lin Zhang, Huirong …

Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer

It’s only fair to share… 4-(6-chloro-1-oxo-3-thioxo-9,9a-dihydro-1H-imidazo[1,5-a]indol-2(3H)-yl)-2-(trifluoromethyl)-benzonitrile WILL BE UPDATED……… Prostate cancer, one of the most malignant tumors worldwide, is the second leading cause of cancer deaths among men in America . Although androgen deprivation therapy (ADT) has been proved to be effective initially, the tumor will eventually progress and develop into the lethal castration resistant …

BMS-741672

It’s only fair to share… BMS-741672 N-((1R,2S,5R)-5-(Isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide BMS-741672 N-((lR,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6- (trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-l-yl)cyclohexyl)acetamide N-((1R,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide; C25 H33 F3 N6 O2, 506.56 Acetamide, N-[(1R,2S,5R)-5-[methyl(1-methylethyl)amino]-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)-4-quinazolinyl]amino]-1-pyrrolidinyl]cyclohexyl]- CAS 1004757-96-3 PHASE 2, , Treatment of Type 2 Diabetes, Agents for Neuropathic Pain Chemokine CCR2 (MCP-1 Receptor) Antagonists Molecular Formula: C25H33F3N6O2 Molecular Weight: 506.574 g/mol Michael G. Yang, Robert J. Cherney Original Assignee Bristol-Myers Squibb Company Michael G. Yang, …

Cetilistat, セチリスタット

It’s only fair to share… Cetilistat, セチリスタット Molecular FormulaC25H39NO3 Average mass401.582 Da CAS 282526-98-1 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one 282526-98-1 [RN] 2-Hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one 2-hexadecyl-oxy-6-methyl-4H-3,1-benzoxazin-4-one 4H-3,1-Benzoxazin-4-one, 2-(hexadecyloxy)-6-methyl [282526-98-1] 2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one ATL-962; ATL962;ATL 962 Trade Name:Oblean® MOA:Pancreatic lipase inhibitor Indication:Obesity Status:Approved, 2013-09-20 JAPAN,  Japan PMDA. Company:Norgine (Originator) , Takeda Cetilistat was approved by Pharmaceuticals Medical Devices Agency of Japan (PMDA) on September 20, 2013. It was …

BMS-442608

It’s only fair to share… BMS-442608 8-Azaspiro(4.5)decane-7,9-dione, 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6R)- (6R)-6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione (R)-6-Hydroxybuspirone, UNII-93881477KV, CAS 477930-30-6, Molecular Formula, C21-H31-N5-O3, Molecular Weight, 401.5079 BMS-442608 is a 5-HT1A partial agonist. BMS-442608 is the R-enantiomer. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer. (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the …

BMS-852927

It’s only fair to share… BMS-852927 CAS 256918-39-4 609.51 MW C29 H28 Cl2 F2 N2 O4 S MF 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol 1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-α,α-dimethyl- Treat metabolic syndrome   Brett Busch, Ph.D. https://www.linkedin.com/in/brettbbusch Brett B. Busch, William C. Stevens, Jr., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu,Richard Martin, Raju Mohan Applicant Exelixis, Inc. Brett B. Busch, William C. Stevens, JR., …

WAY-315193

It’s only fair to share…   7-fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one 7-f luoro-1 -[(1 S,2R)-1 -(3-fluorophenyl)-2-hydroxy-3- (methylamino)propyl]-3,3- dimethyl-1 ,3-dihydro-2H-indol-2-one hydrochloride WAY-315193 7-fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methyl amino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one; Molecular Formula: C20H22F2N2O2 Molecular Weight: 360.397686 g/mol 7-Fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethylindolin-2-one Hydrochloride Callain Younghee Kim, Paige Erin Mahaney,Eugene John Trybulski, Puwen Zhang,Eugene Anthony Terefenko, Casey Cameron Mccomas, Michael Anthony Marella, Richard Dale Coghlan, Gavin David Heffernan,Stephen Todd Cohn, An …

CB-618

It’s only fair to share…   CB-618, CB-238618 CAS 1463520-70-8 C8 H10 N4 O6 S, 290.25 Sulfuric acid, mono[(1R,2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester (25, 5R)-sulfuric acid mono-(2-[l,3,4]oxadiazol-2-yl-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-6-yl) ester SODIUM SALT sodium salt of (2S,5R)-sulfuric acid mono-(2-[1,3,4]oxadiazol-2-yl-7-oxo-1,6-diaza-bicyclo[3.2.1]oct-6-yl)ester CAS 1628207-16-8 C8 H10 N4 O6 S . Na Sulfuric acid, mono[(1R,2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1) PATENTS WO2013149121 US 20140275001 US 20150094472 WO 2016081452 Infection, multidrug …

Register Today for the ACS Symposium in India on Recent Advances in Drug Development, 11-12 November 2016 in Hyderabad, India

It’s only fair to share… Inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India Recent Advances in Drug Development Register Today for the ACS Symposium in India on Recent Advances in Drug Development To view this email as a web page, go here. Register now for the inaugural ACS Industry Symposium, 11-12 November 2016 …

Ranitidine

It’s only fair to share… Ranitidine Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production.[1] It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome.[1] There is also tentative evidence of benefit for hives.[2] It can be taken by mouth, by …