Pridopidine

It’s only fair to share… Pridopidine Molecular Formula C15H23NO2S Average mass 281.414 Da 346688-38-8  CAS FREE FORM 882737-42-0 (hydrochloride) 1440284-30-9 HBr 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidin 4- (3 -Methanesulfonyl-phenyl ) – 1-propyl -piperidine ACR16 Huntexil UNII-HD4TW8S2VK; 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine ACR 16 ASP 2314 FR 310826 Huntingtons chorea Dopamine D2 receptor antagonist; Opioid receptor sigma agonist 1 Neurosearch INNOVATORS, In 2012, the product was acquired by …

BMS-960

It’s only fair to share… BMS-960 PRECLINICAL (S)-1-((S)-2-Hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic Acid 3-Piperidinecarboxylic acid, 1-[(2S)-2-hydroxy-2-[4-[5-[3-phenyl-4-(trifluoromethyl)-5-isoxazolyl]-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-, (3S)- (S)-1-((S)-2-Hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic Acid CAS 1265321-86-5 FREE FORM FREE FORM 528.48, C26 H23 F3 N4 O5 CAS 1265323-40-7 HCL SALT BASIC PATENT WO201117578, 2011, (US Patent 8399451) Inventors John L. Gilmore, James E. Sheppeck Applicant Bristol-Myers Squibb Company   Sphingosine-1-phosphate (S1P) is the endogenous ligand for the …

Plinabulin

It’s only fair to share… Plinabulin Molecular FormulaC19H20N4O2 Average mass336.388 Da (3Z,6Z)-3-Benzylidène-6-{[4-(2-méthyl-2-propanyl)-1H-imidazol-5-yl]méthylène}-2,5-pipérazinedione 2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-, (3Z,6Z)- CAS 714272-27-2 NPI 2358 NPI-2358; NPI 2358 UNII:986FY7F8XR Phase 3 Clinical Tubulin antagonist Cancer; Febrile neutropenia; Non-small-cell lung cancer Plinabulin (chemical structure, BPI-2358, formerly NPI-2358) is a small molecule under development by BeyondSpring Pharmaceuticals, and is in a world-wide Phase …

Telcagepant Revisited

It’s only fair to share… Telcagepant, MK-0974 Molecular FormulaC26H27F5N6O3 Average mass566.523 Da 1-piperidinecarboxamide, N-[(3R,6S)-6-(2,3-difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-  CAS 781649-09-0 OriginatorMerck & Co ClassAntimigraines; Piperidines Mechanism of ActionCalcitonin gene-related peptide receptor antagonists Migraine is a neurovascular disorder characterized by severe, debilitating, and throbbing unilateral headache. Though a leading cause of disability, it is a highly prevalent disease with a clear unmet …

Nonsteroidal antiandrogens, (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide

It’s only fair to share…   C12 H17 Br N2 O3, 317.18 Butanamide, N-(2-bromo-6-methoxy-4-pyridinyl)-2-hydroxy-2,3-dimethyl-, (2S)- (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide (S)-N-(2-Bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide CAS 1433905-44-2 Nonsteroidal antiandrogens HPLC (Daicel Chiralpak IC 250 × 4.6 mm, 5 μm, n-heptane/IPA/TFA 930:70:1, 1 mL·min–1, 25 °C, UV 210 nm): tr (minor) = 5.1 min, tr (major) = 5.9 min. NMR 1H (400 MHz, DMSO-d6): 10.0 …

Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

It’s only fair to share… Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03123D, Paper Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Bing-Shiou Yang, Jonathan T. Reeves, Kanwar Sidhu, Max Sarvestani, Zhulin Tan, Yongda Zhang, Ning Li, Heewon Lee, …

FOTAGLIPTIN

It’s only fair to share…   FOTAGLIPTIN CAS 1312954-58-7 342.37, C17 H19 F N6 O Benzonitrile, 2-[[3-[(3R)-3-amino-1-piperidinyl]-6-methyl-5-oxo-1,2,4-triazin-4(5H)-yl]methyl]-4-fluoro- (R)-2-((3-(3-amino-piperidin-1-yl)-6-methyl-5-oxo-1,2,4-piperazine-4(5H)-yl)methyl)-4-fluorobenzonitrile, BENZOATE 1403496-40-1 (R) 2- Methyl-5-oxo-1,2,4-triazin-4 (5H) -yl) methyl) -4-fluorobenzonitrile (3- benzoate (compound benzoate A), of the formula: the C . 17 the H 19 the FN . 6 O · the C . 7 the H . 6 O 2 …

Brigatinib, Бригатиниб, بريغاتينيب , 布格替尼 ,

It’s only fair to share… Brigatinib, AP26113 Molecular Formula: C29H39ClN7O2P Molecular Weight: 584.102 g/mol CAS 1197953-54-0 2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]- Бригатиниб[Russian][INN] بريغاتينيب[Arabic][INN] 布格替尼[Chinese][INN] 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine AP-26113 MFCD29472221 UNII:HYW8DB273J In 2016, orphan drug designation was assigned to the compound in the U.S. for the treatment of ALK, ROS1 or EGFR-positive non-small cell lung cancer (NSCLC). WO 2009143389 PDT PAT Inventors Yihan …

HS-10168

It’s only fair to share… HS-10168 CAS 1394346-15-6 471.26, C21 H19 Cl2 F2 N2 O2 P (R)-(4-(6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine Oxide (HS-10168) 2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[4-(dimethylphosphinyl)-2-fluorophenyl]- HS-10168 is a potent and selective mesenchymal epithelial transition factor/anaplastic lymphoma kinase (c-Met/ALK) inhibitor that has advanced into Phase I clinical trials.(1, 2) Inventors Baihua Hu, Kan He, Minsheng Zhang Applicant Jiangsu Hansoh Pharmaceutical Co., …

Amtolmetin guacil, амтолметин гуацил , أمتولمتين غواسيل , 呱氨托美丁

It’s only fair to share… Amtolmetin guacil, ST-679, MED-15, Eufans CAS 87344-06-7 UNII: 323A00CRO9,  Molecular Formula, C24-H24-N2-O5, Molecular Weight, 420.463, 2-Methoxyphenyl 1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate Glycine, N-((5-benzoyl-1-methyl-1H-pyrrol-2-yl)acetyl)-, 2-methoxyphenyl ester Trade names: Amtoril®, Artricol®, Artromed® US 4578481, US 6288241, MEDOSAN RICERCA S.R.L. [IT/IT]; Via Cancelliera, 12 I-00040 Cecchina RM (IT) (For All Designated States Except US). SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE …