It’s only fair to share… Pacritinib パクリチニブ; Formula C28H32N4O3 CAS 937272-79-2 Mol weight 472.5787 UPDATE FDA APPROVED 2/28/2022, Vonjo To treat intermediate or high-risk primary or secondary myelofibrosis in adults with low platelets A Jak2 inhibitor potentially for the treatment of acute myeloid Leukemia and myelofibrosis. UNII-G22N65IL3O пакритиниб باكريتينيب 帕瑞替尼 ONX-0803; SB-1518 CAS No. …
TRIAMCINOLONE
It’s only fair to share… TRIAMCINOLONE Molecular FormulaC21H27FO6 Average mass394.434 Da (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (8S,9R,10S,11S,13S,14S,16R,17S)-9-Fluor-11,16,17-trihydroxy-17-(hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(hydroxyacétyl)-10,13-diméthyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one (8S,9R,10S,11S,13S,14S,16R,17S)-9-Fluoro-17-glycoloyl-11,16,17-trihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 124-94-7 [RN] 16a-Hydroxy-9a-fluoroprednisolone 1ZK20VI6TY 204-718-7 [EINECS] 755 9a-Fluoro-16a-hydroxyprednisolone TU3850000 トリアムシノロン[Japanese] 去炎松[Chinese] Triamcinolone CAS Registry Number: 124-94-7 CAS Name: (11b, 16a)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Additional Names: D1-9a-fluoro-16a-hydroxyhydrocortisone; 9a-fluoro-16a-hydroxyprednisolone; D1-16a-hydroxy-9a-fluorohydrocortisone; 16a-hydroxy-9a-fluoroprednisolone Manufacturers’ Codes: CL-19823 Trademarks: Aristocort (Lederle); Kenacort (BMS); Ledercort (tabl.) (Lederle); Omcilon (BMS); Tricortale (Bergamon); Volon (BMS) Molecular Formula: C21H27FO6, Molecular Weight: 394.43 Percent …
Ensitrelvir
It’s only fair to share… Ensitrelvir S-217622, S 217622, Xocova, SHIONOGI, 6-[(6-chloro-2-methylindazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4-dione CAS 2647530-73-0 C22H17ClF3N9O2531.9 Synonyms BDBM513874 bioRxiv20220126.477782, S-217622 Ensitrelvir fumarate CAS No. : 2757470-18-9 C22 H17 Cl F3 N9 O2 . C4 H4 O4 1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)-, (2E)-2-butenedioate (1:1) Formula: C26H21ClF3N9O6 M. Wt. : 647.95 A Phase 1 study of S-217622 in healthy adult participants (jRCT2031210202) Japan Registry of Clinical Trials Web Site 2021, July …
RADOTINIB
It’s only fair to share… RADOTINIB Molecular FormulaC27H21F3N8O Average mass530.504 Da 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(2-pyrazinyl)-2-pyrimidinyl]amino}benzamide 4-methyl-N-[3-(4-methylimidazole-l-yl)-5-trifluoromethyl-phenyl] – 3-(4-pyrazine-2-yl-pyrimidine-2-yl amino)benzamide 9242 926037-48-1 [RN] 926037-48-1 (Radotinib); 926037-85-6 (Radotinib 2HCl); Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(2-pyrazinyl)-2-pyrimidinyl]amino]- I284LJY110, IY5511 UNII-I284LJY110 радотиниб رادوتينيب 雷度替尼 MOA：Bcr-Abl tyrosine kinase inhibitor Indication：Chronic myeloid leukemia (CML ) Company：IL-Yang (Originator) IY-5511; IY-5511A3001 Approval Date Approval Type Trade Name Indication Dosage Form Strength Company Review Classification …
Cyclobenzaprine
It’s only fair to share… Cyclobenzaprine Molecular FormulaC20H21N Average mass275.387 Da MK-130 TNX-102 1-(3-Dimethylaminopropylidene)-2,3:6,7-dibenzo-4-suberene 1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl- [ACD/Index Name] 206-145-8 [EINECS] 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine 303-53-7 [RN] 5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene циклобензаприн [Russian] [INN] سيكلوبنزابرين [Arabic] [INN] 环苯扎林 [Chinese] [INN] Cyclobenzaprine, CAS Registry Number: 303-53-7 CAS Name: 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine Additional Names: N,N-dimethyl-5H-dibenzo[a,d]cyclohepten-D5,g-propylamine; 5-(3-dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene; 1-(3-dimethylaminopropylidene)-2,3:6,7-dibenzo-4-suberene; proheptatriene Manufacturers’ Codes: MK-130; Ro-4-1577; RP-9715 Molecular Formula: C20H21N, Molecular Weight: 275.39 Percent Composition: C 87.23%, H 7.69%, N 5.09% Literature References: Prepn: GB 858187 (1961 to Hoffmann-La Roche); Villani et al., J. …
Pyritinol
It’s only fair to share… Pyritinol Molecular FormulaC16H20N2O4S2 Average mass368.471 Da 1098-97-1 [RN] 1308 214-150-1 [EINECS] 233-178-5 [EINECS] 3,3′-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol] 4-Pyridinemethanol, 3,3′-[dithiobis(methylene)]bis[5-hydroxy-6-methyl- пиритинол [Russian] [INN] بيريتينول [Arabic] [INN] 吡硫醇 [Chinese] [INN] Pyritinol, CAS Registry Number: 1098-97-1 CAS Name: 3,3¢-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol] Additional Names: bis(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl) disulfide; bis[(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)methyl] disulfide; dipyridoxolyldisulfide; pyridoxine-5-disulfide; pyrithioxin Molecular Formula: C16H20N2O4S2, Molecular Weight: 368.47 Percent Composition: C 52.15%, H 5.47%, N 7.60%, O 17.37%, S 17.40% Literature References: Prepn: Zima, Schorre, US 3010966 (1961 to E. Merck); Iwanami et …
Liranaftate
It’s only fair to share… Liranaftate リラナフタート 88678-31-3 (6-Methoxy-2-pyridinyl)methylcarbamothioic Acid O-(5,6,7,8-Tetrahydro-2-naphthalenyl) Ester O-(5,6,7,8-Tetrahydronaphthalen-2-yl) (6-methoxypyridin-2-yl)methylcarbamothioate Zefnart;Piritetrate;M-732 лиранафтат ليرانافتات 利拉萘酯 Formula C18H20N2O2S CAS 88678-31-3 Mol weight 328.4286 Efficacy Antifungal, Ergosterol biosynthesis inhibitor Comment Thiocarbamate Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete’s foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use …
Fabomotizole
It’s only fair to share… Fabomotizole Afobazole Molecular FormulaC15H21N3O2S Average mass307.411 Da 0F8K1X115C 173352-21-1 [RN], 173352-21-1 (free base) 173352-39-1 (HCl) 189638-30-0 (2HCl) 1H-Benzimidazole, 6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]- Obenoxazine, Afobazol, Afobazole, Aphobazole, Fabomotizole dihydrochloride, CM-346, CM346, CM 346, фабомотизол[Russian][INN] فابوموتيزول[Arabic][INN] 法莫替唑[Chinese][INN] Fabomotizole dihydrochloride CAS#: 189638-30-0 (2HCl) Chemical Formula: C15H23Cl2N3O2SMolecular Weight: 380.33 Fabomotizole (also known as Afobazole) is a selective non-benzodiazepine anxiolytic which was …
Sutimlimab-jome
It’s only fair to share… (Heavy chain) EVQLVESGGG LVKPGGSLRL SCAASGFTFS NYAMSWVRQA PGKGLEWVAT ISSGGSHTYY LDSVKGRFTI SRDNSKNTLY LQMNSLRAED TALYYCARLF TGYAMDYWGQ GTLVTVSSAS TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTKTYT CNVDHKPSNT KVDKRVESKY GPPCPPCPAP EFEGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGK (Light chain) QIVLTQSPAT …
ARTEMETHER
It’s only fair to share… ARTEMETHER Molecular FormulaC16H26O5 Average mass298.375 Da (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene (4S,5R,8S,9R,10S,12R,13R)-10-Methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane [ 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (5aS,6R,8aS,9R,10S,12R,12aR)- 71963-77-4 [RN] dihydroartemisinin methyl ether Dihydroqinghaosu Methyl Ether KD4165000 PALUTHER SM 224 SM-224 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,10α,12β,12aR*)]- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin (+)-Artemether Artemether CAS Registry Number: 71963-77-4 CAS Name: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin Additional Names: dihydroartemisinin methyl ether; dihydroqinghaosu methyl ether; o-methyldihydroartemisinin Manufacturers’ Codes: SM-224 Trademarks: Paluther (RPR) Molecular Formula: C16H26O5, Molecular …