It’s only fair to share… BPI-7711, Rezivertinib 1835667-12-3 C27H30N6O3, 486.576 N-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide Beta Pharma in collaboration Chinese licensee CSPC Pharmaceuticals Group , is developing BPI-7711 In June 2021, this drug was reported to be in phase 3 clinical development. APPROVALS 2024, CHINA 2024 OriginatorBeta Pharma ClassAmides; Amines; Antineoplastics; Indoles; Phenyl ethers; Pyrimidines; Small molecules Mechanism of ActionEpidermal …
Tralokinumab
It’s only fair to share… (Heavy chain) QVQLVQSGAE VKKPGASVKV SCKASGYTFT NYGLSWVRQA PGQGLEWMGW ISANNGDTNY GQEFQGRVTM TTDTSTSTAY MELRSLRSDD TAVYYCARDS SSSWARWFFD LWGRGTLVTV SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPS CPAPEFLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ EGNVFSCSVM HEALHNHYTQ KSLSLSLGK (Light chain) SYVLTQPPSV …
Upacicalcet sodium hydrate
It’s only fair to share… Upacicalcet sodium hydrate, ウパシカルセトナトリウム水和物 CAS 2052969-18-1 1333218-50-0 free PMDA JAPAN APPROVED 2021/6/23, Upasita Calcium sensing receptor agonist (2S)-2-amino-3-[(3-chloro-2-methyl-5-sulfophenyl)carbamoylamino]propanoic acid Formula C11H13ClN3O6S. Na. xH2O OriginatorAjinomoto Pharma DeveloperSanwa Kagaku Kenkyusho ClassAmines; Chlorobenzenes; Propionic acids; Small molecules; Sulfonic acids; Toluenes Mechanism of ActionCalcium-sensing receptor agonists RegisteredSecondary hyperparathyroidism 25 Jun 2021Chemical structure information added 23 Jun …
Imeglimin hydrochloride
It’s only fair to share… Meglimin hydrochloride Twymeeg Formula C6H13N5. HCl CAS 775351-61-6 (HCl). , C6H14ClN5 191.66 CAS 775351-65-0, FREEFORM 155.20 Mol weight 191.6619 AntidiabeticAPPROVED PMDA JAPAN2021/6/23, イメグリミン塩酸塩 (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine DB12509 NCGC00378621-02 HY-14771 Q6003719 UNII-UU226QGU97 UU226QGU97 1,3,5-Triazine-2,4-diamine,1,6-dihydro-N,N,6-trimethyl-,(+)-(9CI) (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Imeglimin [INN] Emd 387008 (R-imeglimin) HCl EMD-387008 Imeglimin is an experimental drug being developed as an oral anti-diabetic.[1][2] It is an oxidative phosphorylation blocker that …
CVnCoV, zorecimeran, CureVac COVID-19 vaccine
It’s only fair to share… CVnCoV cas 2541470-90-8 An optimized, non-chemical modified mRNA encoding the prefusion-stabilized full-length spike protein of SARS-CoV-2 virus (Curevac) zorecimeran, CureVac COVID-19 vaccine CureVac/Bayer GSK NCT04674189 NCT04449276 NCT04515147 NCT04652102 EudraCT-2020-004066-19 mRNA-based vaccine PHASE 3 CVnCoV Humoral and cellular responses CD4+ T-cells, CD8+ T-cells N/A N/A Rhesus macaque [124] 124. Rauch S, Gooch …
Tucidinostat, Chidamide
It’s only fair to share… Tucidinostat, Chidamide ツシジノスタット 2021/6/23 PMDA JAPAN APPROVED, Hiyasta Formula C22H19FN4O2 CAS 1616493-44-7 Mol weight 390.4103 Antineoplastic, Histone deacetylase inhibitor Chidamide (Epidaza) is a histone deacetylase inhibitor (HDI) developed in China.[1] It was also known as HBI-8000.[2] It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10.[3] Chidamide is approved by the Chinese FDA for …
Isotretinoin
It’s only fair to share… Isotretinoin Title: Isotretinoin CAS Registry Number: 4759-48-2 CAS Name: 13-cis-Retinoic acid Additional Names: 2-cis-vitamin A acid; neovitamin A acid Manufacturers’ Codes: Ro-4-3780 Trademarks: Accutane (Roche); Isotrex (Stiefel); Oratane (Douglas); Roaccutane (Roche) Molecular Formula: C20H28O2 Molecular Weight: 300.44 Percent Composition: C 79.95%, H 9.39%, O 10.65% Literature References: Naturally occurring metabolite of vitamin A, q.v.; inhibits sebum production. Prepn: C. D. Robeson et …
COVAX-19
It’s only fair to share… Vaxine Pty Ltd company logo Vaxine’s promising new COVID-19 vaccine candidate A new multivalent COVID-19 vaccine developed by Australian company Vaxine to tackle the new virus variants could be game-changer in the fight against COVID-19 The world desperately needs a vaccine that blocks virus transmission and protects against all the …
Uprifosbuvir
It’s only fair to share… Uprifosbuvir MK 3682, IDX 21437 ウプリホスブビル; Formula C22H29ClN3O9P CAS 1496551-77-9 Mol weight 545.9071 уприфосбувир [Russian] [INN] أوبريفوسبوفير [Arabic] [INN] 乌磷布韦 [Chinese] [INN] propan-2-yl (2R)-2-[[[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate Isopropyl (2R)-2-{[(R)-{[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate IDX-21437, DB15206, SB18784, D10996, Q27281714 Uprifosbuvir (MK-3682) is an antiviral drug developed for the treatment of Hepatitis C. It is a nucleotide analogue which acts as an NS5B RNA polymerase inhibitor. It is currently in Phase III human clinical trials.[1][2][3] Uprifosbuvir is under investigation …
ARCT-021 (LUNAR-COV19)
It’s only fair to share… ARCT-021 (LUNAR-COV19) cas 2541451-24-3 A lipid-enabled and UnlockedNucleomonomer Agent modified RNA (LUNAR) of self-replicating RNA for vaccination against spike protein of SARS-CoV-2 (Arcturus) Self-replicating RNA vaccine Arcturus Therapeutics and Duke-NUS Medical School, Singapore OriginatorArcturus Therapeutics ClassCOVID-19 vaccines; RNA vaccines; Viral vaccines Mechanism of ActionImmunostimulants Orphan Drug StatusNo New Molecular EntityNo Available …