It’s only fair to share… Tunlametinib 4-fluoro-5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,3-benzothiazole-6-carboxamide Tunlametinib, an oral selective inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2), was developed by Shanghai KeChow Pharmaceuticals Co., Ltd. Marketed under the brand nameKeluping, Tunlametinib is a pharmaceutical drug for the treatment of cancer. It is an inhbitor of mitogen-activated protein kinase kinase.[1] In China, tunlametinib was …
Befotertinib
It’s only fair to share… Befotertinib D-0316, 0XT2CPR891 CAS No. : 1835667-63-4, MESYLATE CAS No. 2226167-02-6 Molecular Weight 567.61 Formula C29H32F3N7O2 Befotertinib (D-0316) is an orally active EGFR tyrosine kinase inhibitor. Befotertinib can inhibit the proliferation of tumor cells. Befotertinib can be used in the research of EGFR T790M-positive non-small cell lung cancer (NSCLC). Befotertinib is an orally available inhibitor of the epidermal …
Iruplinalkib
It’s only fair to share… Iruplinalkib CAS No. : 1854943-32-0 Molecular Weight 569.08 Formula C29H38ClN6O2P 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)phenyl]pyrimidine-2,4-diamine Iruplinalkib (WX-0593) is an orally active and selective ALK/ROS1 inhibitor. Iruplinalkib can effectively inhibit tyrosine autophosphorylation of ALK and mutant ALK, EGFR, with the IC50 between 5.38 and 16.74 nM. Iruplinalkib is also a suppressive agent of the transporter MATE1, MATE2K, P-gp and BCRP. Iruplinalkib can be used in the study of non-small …
Zongertinib
It’s only fair to share… Zongertinib CAS No. : 2728667-27-2, BI-1810631, BI1810631 Molecular Weight 535.60 Formula C29H29N9O2 FDA 8/8/2025, Hernexeos, To treat adults with unresectable or metastatic non-squamous non-small cell lung cancer whose tumors have HER2 tyrosine kinase domain activating mutations, as detected by an FDA-approved test, and who have received prior systemic therapy Zongertinib is …
Aceclidine
It’s only fair to share… Aceclidine WeightAverage: 169.224Monoisotopic: 169.110278727 Chemical FormulaC9H15NO2 CAS 827-61-2, 3-Acetoxyquinuclidine, 3-Quinuclidinol acetate (ester), Aceclidina, 0578K3ELIO APROVAL 7/31/2025, Vizz. To treat presbyopia 1-azabicyclo[2.2.2]octan-3-yl acetate Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester(aceclidine) MW: 169.22 MF: C9H15NO2LD50: 78 mg/kg (M, i.p.); 36 mg/kg (M, i.v.); 165 mg/kg (M, p.o.); 102 mg/kg (M, s.c.);45 mg/kg (R, i.v.); 225 …
Ropotrectinib
It’s only fair to share… Ropotrectinib WeightAverage: 355.373Monoisotopic: 355.144453003 Chemical FormulaC18H18FN5O2 Repotrectinib, sold under the brand name Augtyro, is an anti-cancer medication used for the treatment of non-small cell lung cancer.[2][5] It is taken by mouth.[2] Repotrectinib is an inhibitor of proto-oncogene tyrosine-protein kinase ROS1 (ROS1) and of the tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC.[2] The most common adverse reactions include dizziness, dysgeusia, peripheral neuropathy, constipation, dyspnea, ataxia, fatigue, cognitive disorders, …
Donafenib
It’s only fair to share… Donafenib CAS 1130115-44-4, CM-4307, Zepsun, 41XGO0VS1U 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide CM-4307 is under investigation in clinical trial NCT03602495 (Donafenib in 131I-Refractory Differentiated Thyroid Cancer). Donafenib, sold under the brand name Zepsun, is a pharmaceutical drug for the treatment of cancer. In China, donafenib is approved for the treatment of unresectable hepatocellular carcinoma in patients who have …
Pamiparib
It’s only fair to share… Pamiparib BGB-290 APPROVED CHINA 2022, BEIGENE (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one Pamiparib, sold under the brand name Partruvix, is a pharmaceutical drug used for the treatment of various types of cancer. Pamiparib is a member of the PARP inhibitor drug class.[1] In China, it is approved for the treatment of germline BRCA mutation-associated recurrent advanced ovarian, fallopian tube, and primary peritoneal …
Sepiapterin
It’s only fair to share… Sepiapterin 17094-01-8 Molecular Weight 237.22 Formula C9H11N5O3 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-3H-pteridin-4-one (S)-2-Amino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one 7/28/2025 fda approved, Sephience, To treat hyperphenylalaninemia in patients with sepiapterin-responsive phenylketonuria, in conjunction with a phenylalanine-restricted diet Sepiapterin, sold under the brand name Sephience, is a medication used for the treatment of hyperphenylalaninemia.[2][3] Sepiapterin is a phenylalanine hydroxylase activator.[1] The most common side effects are upper respiratory …
Olverembatinib
It’s only fair to share… Olverembatinib WeightAverage: 532.571Monoisotopic: 532.219844002, Chemical FormulaC29H27F3N6O 1421783-64-3 Molecular Weight 724.77 Formula C31H35F3N6O7S2 Olverembatinib (GZD824) dimesylate is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib dimesylate potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib dimesylate strongly inhibits native Bcr-Abl and Bcr-AblT315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib dimesylate has antitumor activity. Olverembatinib (dimesylate) is …