It’s only fair to share… Deutivacaftor RN: 1413431-07-8 UNII: SHA6U5FJZL, N-[2-tert-butyl-4-[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]-5-hydroxyphenyl]-4-oxo-1H-quinoline-3-carboxamide Molecular Formula, C24-H28-N2-O3, Molecular Weight, 401.552 Synonyms CTP-656 D9-ivacaftor Deutivacaftor Ivacaftor D9 UNII-SHA6U5FJZL VX-561 WHO 10704 Treatment of Cystic Fibrosis Originator Concert Pharmaceuticals Class Amides; Aminophenols; Antifibrotics; Organic deuterium compounds; Quinolones; Small molecules Mechanism of Action Cystic fibrosis transmembrane conductance regulator stimulants Orphan Drug Status Yes – Cystic fibrosis Phase II Cystic …
VX-659, Bamocaftor potassium
It’s only fair to share… VX-659, BAMOCAFTOR N-(Benzenesulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]- N-(benzenesulfonyl)-6-[3-[2-[l-(trifluoromethyl)cyclopropyl]ethoxy]pyrazol-l-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-l-yl]pyridine-3-carboxamide CAS Number 2204245-48-5 UNII: 8C7XEW3K7S BAMOCAFTOR M. Wt 591.65 Formula C28H32F3N5O4S Bamocaftor potassium CAS 2204245-47-4 Molecular Formula C28 H31 F3 N5 O4 S . K Molecular Weight 629.735 VX-659 VX-659 potassium salt VY7D8MTV72 (UNII code) WHO 11167 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-, potassium salt (1:1) Potassium (benzenesulfonyl)[6-(3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carbonyl]azanide PHASE 2 CYSTIC …
Erdafitinib, エルダフィチニブ ,Эрдафитиниб , إيردافيتينيب , 厄达替尼 ,
It’s only fair to share… Erdafitinib エルダフィチニブ JNJ-42756493 CAS 1346242-81-6 MF, C25H30N6O2, MW 446.54 UNII-890E37NHMV 890E37NHMV 2019/4/12, FDA APPROVED, BALVERSA (Janssen Products LP) Balversa Эрдафитиниб [Russian] [INN] إيردافيتينيب [Arabic] [INN] 厄达替尼 [Chinese] [INN] N‘-(3,5-dimethoxyphenyl)-N‘-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine 1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]- [ACD/Index Name] 10147 1346242-81-6 [RN] 890E37NHMV N-(3,5-dimethoxyphenyl)-N’-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine 5SF MFCD28502040 N’-(3,5-dimethoxyphenyl)-N’-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine Erdafitinib is an orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, erdafitinib binds …
First FDA-approved vaccine Dengvaxia for the prevention of dengue disease in endemic regions
It’s only fair to share… First FDA-approved vaccine for the prevention of dengue disease in endemic regions May 01, 2019 The U.S. Food and Drug Administration announced today the approval of Dengvaxia, the first vaccine approved for the prevention of dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people …
FDA approves first treatment Benlysta (belimumab) for pediatric patients with lupus
It’s only fair to share… The U.S. Food and Drug Administration today approved Benlysta (belimumab) intravenous (IV) infusion for treatment of children with systemic lupus erythematosus (SLE) – often referred to as simply “lupus” – a serious chronic disease that causes inflammation and damage to various body tissues and organs. This is the first …
Ferric carboxymaltose , カルボキシマルトース第二鉄
It’s only fair to share… Ferric carboxymaltose カルボキシマルトース第二鉄 CAS: 9007-72-1 Molecular Formula, C24H44FeO25– Molecular Weight, 788.43616 g/mol (2S,3S,4S,5R)-4-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate Iron dextri-maltose Iron(3+) hydroxide oxide poly-(1–4)-alpha-D-glucopyranosyl-(1–4)-D-gluconate hydrate Polynuclear iron (III)-hydroxide 4(R)-(poly-(1–4)-O-alpha-D-glucopyranosyl)-oxy-2(R),3(S),5(R),6-tetrahydroxy-hexanoate Poly[D-glucopyranosyl(1–4)]-D-gluconic acid complex of hydrated iron(III) oxide japan pmda approved, 2019/3/26, Ferinject Treatment of patients with iron deficiency anemia Hematinic, Supplement (iron) LAUNCHED, 2007, Vifor Pharma, Anemia, iron deficiency 1 Injectafer 2. Ferinject 3. Iron Dextri-maltose …
Thiotepa, チオテパ ,тиотепа , ثيوتيبا , 塞替派 ,
It’s only fair to share… Thiotepa, チオテパ Use:antineoplastic, alkylating agent Chemical name:1,1′,1”-phosphinothioylidynetrisaziridine Formula:C6H12N3PS MW:189.22 g/mol CAS:52-24-4 EINECS:200-135-7 LD50:14500 μg/kg (M, i.v.); 38 mg/kg (M, p.o.); 9400 μg/kg (R, i.v.) Aziridine, 1,1′,1”-phosphinothioylidynetris- Aziridine, 1-[bis(1-aziridinyl)phosphinothioyl]- N,N’,N”-Triethylenethiophosphoramide Phosphorothioic tri(ethyleneamide) SZ2975000 T3NTJ APS&- AT3NTJ&– AT3NTJ [WLN] Thiofozil Thiotef 1,1′,1”-Phosphorothioyltriaziridine JAPAN APPROVED, Rethio, PMDA, 2019/3/26 тиотепа [Russian] [INN] ثيوتيبا [Arabic] [INN] 塞替派 [Chinese] [INN] Thiotepa (INN,[1] chemical name: N,N′,N′′-triethylenethiophosphoramide) is an alkylating agent used …
Peficitinib hydrobromide, ペフィシチニブ臭化水素酸塩
It’s only fair to share… Peficitinib hydrobromide ペフィシチニブ臭化水素酸塩 ASP015K, Rheumatoid Arthritis 1H-Pyrrolo(2,3-b)pyridine-5-carboxamide, 4-((5-hydroxytricyclo(3.3.1.13,7)dec-2-yl)amino)-, hydrobromide (1:1), stereoisomer 4-{[(1R,2s,3S,5r)-5-Hydroxyadamantan-2-yl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide (1:1) 1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[[(1R,3S)-5-hydroxytricyclo[3.3.1.13,7]dec-2-yl]amino]-, hydrobromide (1:1) U55XHZ5X6P Formula C18H22N4O2. HBr CAS 1353219-05-2 HBR 944118-01-8 BASE Mol weight 407.3048 PMDA, 2019/3/26 JAPAN APPROVED, Smyraf Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis Peficitinib (formerly known as ASP015K) is …
Cefamandole, セファマンドール ,цефамандол , سيفاماندول , 头孢孟多 ,
It’s only fair to share… Cefamandole セファマンドール цефамандол [Russian] [INN] سيفاماندول [Arabic] [INN] 头孢孟多 [Chinese] [INN] CAS Registry Number: 34444-01-4 CAS Name: (6R,7R)-7-[[(2R)-Hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Additional Names: 7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-D-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid; 7-D-mandelamido-3-(1-methyl-1,2,3,4-tetrazole-5-thiomethyl)-D3-cephem-4-carboxylic acid; CMT Manufacturers’ Codes: compd 83405 Molecular Formula: C18H18N6O5S2 Molecular Weight: 462.50 Percent Composition: C 46.74%, H 3.92%, N 18.17%, O 17.30%, S 13.87% Literature References: Broad-spectrum semi-synthetic cephalosporin antibiotic. Prepn: C. W. Ryan, DE 2018600; idem, US3641021 (1970, 1972 to Lilly); …
VIXOTRIGINE, NEW PATENT, WO-2019071162, BIOGEN INC
It’s only fair to share… VIXOTRIGINE, NEW PATENT, WO-2019071162, BIOGEN INC https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019071162&redirectedID=true vixotrigine Process for preparing α-carboxamide pyrrolidine derivatives (particularly vixotrigine ) and its intermediates are modulators of use-dependent voltage-gated sodium channels Biogen, following the acquisition of Convergence Pharmaceuticals, that previously acquired clinical assets from GSK is developing vixotrigine a voltage-gated sodium channel 1.7 inhibitor, for the …