It’s only fair to share… Donidalorsen CAS 2304692-48-4 분자량 Mw 8672.64 화학식Mf C296H435N83O151P20S15 ISIS 721744, ISIS-721744 FDA 8/21/2025, Dawnzera, To prevent attacks of hereditary angioedema DNA, D((2′-O-(2-METHOXYETHYL))M5RU-SP-(2′-O-(2-METHOXYETHYL))RG-SP-(2′-O-(2-METHOXYETHYL))M5RC-(2′-O-(2-METHOXYETHYL))RA-(2′-O-(2-METHOXYETHYL))RA-SP-G-SP-T-SP-M5C-SP-T-SP-M5C-SP-T-SP-T-SP-G-SP-G-SP-M5C-SP-(2′-O-(2-METHOXYETHYL))RA-(2′-O-(2-METHOXYETHYL) Ingredient UNII CAS . Donidalorsen sodium Y30VEG5PH1 2304701-45-7 Donidalorsen, sold under the brand name Dawnzera, is a medication used to prevent attacks of hereditary angioedema.[1] Donidalorsen is a prekallikrein-directed antisense oligonucleotide.[1] It is given by injection under …
Tag «APPROVALS 2025»
Bevifibatide
It’s only fair to share… Bevifibatide Cas 710312-77-9 817.9 g/mol, C34H47N11O9S2 2-[(3S,6S,12S,20R,23S)-20-carbamoyl-12-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid APPROVALS 2025, CHINA 2025, Bio-Thera Solutions, Beitaning RegisteredAcute coronary syndromes BAT-2094 | batifiban | Beitaning | Betagrin® | Compound I [CN101085809A] Bevifibatide is a synthetic cyclic heptapeptide, and its synthesis involves several stages of peptide chemistry. The primary methods used for producing peptides of this nature are solid-phase peptide synthesis (SPPS), …
Tegileridine
It’s only fair to share… Tegileridine WeightAverage: 434.624Monoisotopic: 434.293328472 Chemical FormulaC28H38N2O2 (1S,4S)-4-ethoxy-N-[2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]-1,2,3,4-tetrahydronaphthalen-1-amine Tegileridine fumarate CAS#2245827-85-2 (fumarate) Chemical Formula: C32H42N2O6 Exact Mass: 550.3000 Molecular Weight: 550.70 CHINA 2025, APPROVALS 2025, AISUTE, Jiangsu Hengrui Tegileridine is under investigation in clinical trial NCT06458400 (To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain). Tegileridine is a drug …
Brensocatib
It’s only fair to share… Brensocatib WeightAverage: 420.469Monoisotopic: 420.179755269 Chemical FormulaC23H24N4O4 (2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide FDA 8/12/2025. Brinsupri, To treat non-cystic fibrosis bronchiectasis Brensocatib is an investigational new drug that is being evaluated to treat bronchiectasis.[1] It is a dipeptidyl-peptidase I (also known as cathepsin C) inhibitor.[2] A phase 3 clinical trial, known as the ASPEN trial, was conducted to evaluate the safety and efficacy of …
Dordaviprone
It’s only fair to share… Dordaviprone WeightAverage: 386.499Monoisotopic: 386.210661473 Chemical FormulaC24H26N4O 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one Product Ingredients Ingredient UNII CAS InChI Key Dordaviprone dihydrochloride 53VG71J90J 1638178-82-1 Not applicable FDA 8/6/2025, Modeyso, To treat diffuse midline glioma harboring an H3 K27M mutation with progressive disease following prior therapy Dordaviprone, sold under the brand name Modeyso is an anti-cancer medication used for the treatment …
Zongertinib
It’s only fair to share… Zongertinib CAS No. : 2728667-27-2, BI-1810631, BI1810631 Molecular Weight 535.60 Formula C29H29N9O2 FDA 8/8/2025, Hernexeos, To treat adults with unresectable or metastatic non-squamous non-small cell lung cancer whose tumors have HER2 tyrosine kinase domain activating mutations, as detected by an FDA-approved test, and who have received prior systemic therapy Zongertinib is …
Aceclidine
It’s only fair to share… Aceclidine WeightAverage: 169.224Monoisotopic: 169.110278727 Chemical FormulaC9H15NO2 CAS 827-61-2, 3-Acetoxyquinuclidine, 3-Quinuclidinol acetate (ester), Aceclidina, 0578K3ELIO APROVAL 7/31/2025, Vizz. To treat presbyopia 1-azabicyclo[2.2.2]octan-3-yl acetate Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester(aceclidine) MW: 169.22 MF: C9H15NO2LD50: 78 mg/kg (M, i.p.); 36 mg/kg (M, i.v.); 165 mg/kg (M, p.o.); 102 mg/kg (M, s.c.);45 mg/kg (R, i.v.); 225 …
Ropotrectinib
It’s only fair to share… Ropotrectinib WeightAverage: 355.373Monoisotopic: 355.144453003 Chemical FormulaC18H18FN5O2 Repotrectinib, sold under the brand name Augtyro, is an anti-cancer medication used for the treatment of non-small cell lung cancer.[2][5] It is taken by mouth.[2] Repotrectinib is an inhibitor of proto-oncogene tyrosine-protein kinase ROS1 (ROS1) and of the tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC.[2] The most common adverse reactions include dizziness, dysgeusia, peripheral neuropathy, constipation, dyspnea, ataxia, fatigue, cognitive disorders, …
Sepiapterin
It’s only fair to share… Sepiapterin 17094-01-8 Molecular Weight 237.22 Formula C9H11N5O3 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-3H-pteridin-4-one (S)-2-Amino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one 7/28/2025 fda approved, Sephience, To treat hyperphenylalaninemia in patients with sepiapterin-responsive phenylketonuria, in conjunction with a phenylalanine-restricted diet Sepiapterin, sold under the brand name Sephience, is a medication used for the treatment of hyperphenylalaninemia.[2][3] Sepiapterin is a phenylalanine hydroxylase activator.[1] The most common side effects are upper respiratory …
Sebetralstat
It’s only fair to share… Sebetralstat, KVD 900 CAS 1933514-13-6 491.5 g/mol O5ZD2TU2B7 FDA 7/3/2025, Ekterly, To treat acute attacks of hereditary angioedema N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxopyridin-1-yl)methyl]phenyl]methyl]pyrazole-4-carboxamide Sebetralstat, sold under the brand name Ekterly, is a medication used for the treatment of hereditary angioedema.[1] Sebetralstat is a plasma kallikrein inhibitor.[1] Sebetralstat was approved for medical use in the United States in July 2025.[1][2] SYN https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00921 aReagents …