It’s only fair to share… Taletrectinib CAS 1505514-27-1 as salt: 1505515-69-4, Taletrectinib adipate FDA 6/11/2025, Ibtrozi, To treat locally advanced or metastatic ROS1-positive non-small cell lung cancer AB-106, DS-6051a 405.5 g/mol, C23H24FN5O, UNII-W4141180YD 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine Taletrectinib adipate WeightAverage: 551.619Monoisotopic: 551.254397378 Chemical FormulaC29H34FN5O5 DS-6051B, CAS 1505515-69-4, 6KLL51GNBG, 3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine; hexanedioic acid Taletrectinib, sold under the brand name Ibtrozi, is an anti-cancer medication used …
Tag «CANCER»
Alflutinib, Furmonertinib, Firmonertinib
It’s only fair to share… FIRMOMERTINIB, Furmonertinib, Alflutinib CAS 1869057-83-9 , AST 2818, UNII-A49A7A5YN4 N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-2-propenamide N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]prop-2-enamide C28H31F3N8O2 568.6 g/mol 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]- Alflutinib is under investigation in clinical trial NCT03452592 (Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients With T790M). Firmonertinib is an orally available selective inhibitor of the epidermal growth …
Tibremciclib
It’s only fair to share… Tibremciclib cas 2397678-18-9, GTPL12881 CRB7BT5JDQ 518.6 g/mol, C28H32F2N8 N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-[(1R)-6-fluoro-1-methyl-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-8-yl]pyrimidin-2-amine Tibremciclib is a CDK4 inhibitor with antineoplastic activity[1]. 13 Sep 2024 Efficacy and adverse event data from a phase III trial in Breast cancer presented at the 49th European Society for Medical Oncology Congress 2024 (ESMO-2024) Cyclin-dependent kinases (CDKs) are a class of serine …
Amcenestrant (SAR 439859)
It’s only fair to share… Amcenestrant (SAR 439859) アムセネストラント Molecular Weight 554.48 Formula C31H30Cl2FNO3 CAS No. 2114339-57-8 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid Amcenestrant 8-(2,4-dichlorophenyl)-9-(4-{[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxy}phenyl)-6,7-dihydro – 5H- Benzo[7]annulene-3-carboxylic acid 8-(2,4-Dichlorophenyl)-9-(4-{[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxy}phenyl)-6,7-dihydro-5 H -benzo [7]annulene-3-carboxylic acid C31H30Cl2FNO3 : 554.48 [ 2114339-57-8 ] _ _ _ _ _ _ Efficacy Antineoplastic, Selective estrogen receptor downregulator Comment Selective estrogen receptor downregulator (SERD) Treatment of breast cancer SAR439859 (compound 43d) is an orally active, nonsteroidal and selective estrogen receptor degrader …
LORPUCITINIB
It’s only fair to share… LORPUCITINIB JNJ 64251330 2230282-02-5 UNII-OE1QTY7C25 Molecular Weight 408.50 Formula C22H28N6O2 1-(TRANS-4-(CYANOMETHYL)CYCLOHEXYL)-1,6-DIHYDRO-N-(2-HYDROXY-2-METHYLPROPYL)IMIDAZO(4,5-D)PYRROLO(2,3-B)PYRIDINE-2-ACETAMIDE 2-[3-[4-(cyanomethyl)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]-N-(2-hydroxy-2-methylpropyl)acetamide is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease. Lorpucitinib is an orally bioavailable pan-inhibitor of the Janus associated-kinases (JAKs), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, lorpucitinib works in the gastrointestinal (GI) tract …
Camizestrant, AZD 9833
It’s only fair to share… Camizestrant, AZD 9833 AZ 14066724 PHASE 2 CAS: 2222844-89-3 Chemical Formula: C24H28F4N6 Exact Mass: 476.2312 Molecular Weight: 476.5236 Elemental Analysis: C, 60.49; H, 5.92; F, 15.95; N, 17.64 N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine AZ14066724 AZD-9833 AZD9833 Camizestrant UNII-JUP57A8EPZ WHO 11592 OriginatorAstraZeneca ClassAmines; Antineoplastics; Azetidines; Fluorinated hydrocarbons; Isoquinolines; Pyrazolones; Pyridines; Small molecules Mechanism …
GEMCITABINE
It’s only fair to share… GEMCITABINE 95058-81-4 WeightAverage: 263.1981 Monoisotopic: 263.071762265 Chemical FormulaC9H11F2N3O4 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one Product Ingredients INGREDIENT UNII CAS INCHI KEY Gemcitabine hydrochloride U347PV74IL 122111-03-9 OKKDEIYWILRZIA-OSZBKLCCSA-N LY-188011 LY188011 Gemcitabine CAS Registry Number: 95058-81-4 CAS Name: 2¢-Deoxy-2¢,2¢-difluorocytidine Additional Names: 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; dFdC; dFdCyd Manufacturers’ Codes: LY-188011 Trademarks: Gemzar (Lilly) Molecular Formula: C9H11F2N3O4 Molecular Weight: 263.20 Percent Composition: C 41.07%, H 4.21%, F 14.44%, N …
OTERACIL POTTASIUM
It’s only fair to share… OTERACIL UNII4R7FFA00RX, CAS Number2207-75-2, WeightAverage: 195.175, Monoisotopic: 194.96823705, Chemical FormulaC4H2KN3O4 [K+].OC1=NC(=NC(=O)N1)C([O-])=O 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, potassium salt (1:1) 218-627-5 [EINECS] 2207-75-2 [RN] 4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt KOX NSC 28841 Oxonate Oxonate, potassium CDSCO APPROVED,01.02.2022 Gimeracil bulk & Oteracil potassium bulk and Tegafur 15mg/20mg, Gimeracil 4.35mg/5.8mg and Oteracil 11.8mg/15.8mg capsules indicated in adults for the treatment …
GIMERACIL
It’s only fair to share… GIMERACIL C5H4ClNO2, 145.54 103766-25-2 5-chloro-4-hydroxy-1H-pyridin-2-one 5-Chloro-2,4-dihydroxypyridine 5-chloropyridine-2,4-diol 5-Chloro-4-hydroxy-2(1H)-pyridone Ts-1 (TN) CCDSCO APPROVED,01.02.2022 Gimeracil bulk & Oteracil potassium bulk and Tegafur 15mg/20mg, Gimeracil 4.35mg/5.8mg and Oteracil 11.8mg/15.8mg capsules indicated in adults for the treatment of advanced gastric cancer when given in combination with cisplatin. Tegafur/gimeracil/oteracil Combination of Tegafur Antineoplastic drug Gimeracil …
TNO 155
It’s only fair to share… TNO 155 2-Oxa-8-azaspiro[4.5]decan-4-amine, 8-[6-amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-, (3S,4S)- (3S,4S)-8-[6-Amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine (3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine Molecular Weight 421.95 Formula C₁₈H₂₄ClN₇OS CAS No. 1801765-04-7 PTPN11 inhibitor TNO155 SHP2 inhibitor TNO155 TNO-155 TNO155 UNII-FPJWORQEGI TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially …