Tag «CANCER»

LORPUCITINIB

It’s only fair to share…   LORPUCITINIB JNJ 64251330 2230282-02-5 UNII-OE1QTY7C25 Molecular Weight 408.50 Formula C22H28N6O2 1-(TRANS-4-(CYANOMETHYL)CYCLOHEXYL)-1,6-DIHYDRO-N-(2-HYDROXY-2-METHYLPROPYL)IMIDAZO(4,5-D)PYRROLO(2,3-B)PYRIDINE-2-ACETAMIDE 2-[3-[4-(cyanomethyl)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]-N-(2-hydroxy-2-methylpropyl)acetamide is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease. Lorpucitinib is an orally bioavailable pan-inhibitor of the Janus associated-kinases (JAKs), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, lorpucitinib works in the gastrointestinal (GI) tract …

Camizestrant, AZD 9833

It’s only fair to share… Camizestrant, AZD 9833 AZ 14066724 PHASE 2 CAS: 2222844-89-3 Chemical Formula: C24H28F4N6 Exact Mass: 476.2312 Molecular Weight: 476.5236 Elemental Analysis: C, 60.49; H, 5.92; F, 15.95; N, 17.64  N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine   AZ14066724 AZD-9833 AZD9833 Camizestrant UNII-JUP57A8EPZ WHO 11592   OriginatorAstraZeneca ClassAmines; Antineoplastics; Azetidines; Fluorinated hydrocarbons; Isoquinolines; Pyrazolones; Pyridines; Small molecules Mechanism …

GEMCITABINE

It’s only fair to share… GEMCITABINE 95058-81-4 WeightAverage: 263.1981 Monoisotopic: 263.071762265 Chemical FormulaC9H11F2N3O4 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one Product Ingredients INGREDIENT UNII CAS INCHI KEY Gemcitabine hydrochloride U347PV74IL 122111-03-9 OKKDEIYWILRZIA-OSZBKLCCSA-N   LY-188011 LY188011 Gemcitabine CAS Registry Number: 95058-81-4 CAS Name: 2¢-Deoxy-2¢,2¢-difluorocytidine Additional Names: 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; dFdC; dFdCyd Manufacturers’ Codes: LY-188011 Trademarks: Gemzar (Lilly) Molecular Formula: C9H11F2N3O4 Molecular Weight: 263.20 Percent Composition: C 41.07%, H 4.21%, F 14.44%, N …

OTERACIL POTTASIUM

It’s only fair to share… OTERACIL UNII4R7FFA00RX, CAS Number2207-75-2,  WeightAverage: 195.175, Monoisotopic: 194.96823705, Chemical FormulaC4H2KN3O4 [K+].OC1=NC(=NC(=O)N1)C([O-])=O 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, potassium salt (1:1) 218-627-5 [EINECS] 2207-75-2 [RN] 4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt KOX NSC 28841 Oxonate Oxonate, potassium CDSCO APPROVED,01.02.2022 Gimeracil bulk & Oteracil potassium bulk and Tegafur 15mg/20mg, Gimeracil 4.35mg/5.8mg and Oteracil 11.8mg/15.8mg capsules indicated in adults for the treatment …

GIMERACIL

It’s only fair to share… GIMERACIL C5H4ClNO2, 145.54   103766-25-2 5-chloro-4-hydroxy-1H-pyridin-2-one 5-Chloro-2,4-dihydroxypyridine 5-chloropyridine-2,4-diol 5-Chloro-4-hydroxy-2(1H)-pyridone Ts-1 (TN) CCDSCO APPROVED,01.02.2022 Gimeracil bulk & Oteracil potassium bulk and Tegafur 15mg/20mg, Gimeracil 4.35mg/5.8mg and Oteracil 11.8mg/15.8mg capsules indicated in adults for the treatment of advanced gastric cancer when given in combination with cisplatin. Tegafur/gimeracil/oteracil Combination of Tegafur Antineoplastic drug Gimeracil …

TNO 155

It’s only fair to share… TNO 155 2-Oxa-8-azaspiro[4.5]decan-4-amine, 8-[6-amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-, (3S,4S)- (3S,4S)-8-[6-Amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine (3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine Molecular Weight 421.95 Formula C₁₈H₂₄ClN₇OS CAS No. 1801765-04-7   PTPN11 inhibitor TNO155 SHP2 inhibitor TNO155 TNO-155 TNO155 UNII-FPJWORQEGI   TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially …

AUPM 170, CA 170, PD-1-IN-1

It’s only fair to share… (2S,3R)-2-(3-((S)-3-amino-1-(3-((R)-1-amino-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)-3-oxopropyl)ureido)-3-hydroxybutanoic acid Molecular Weight (MW)  360.33 Formula  C12H20N6O7 CAS No.  1673534-76-3 N-[[[(1S)-3-Amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]amino]carbonyl]-L-threonine L-Threonine, N-[[[(1S)-3-amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]amino]carbonyl]-  AUPM 170, CA 170, AUPM-170, CA-170, PD-1-IN-1 Novel inhibitor of programmed cell dealth-1 (PD-1) CA-170 (also known as AUPM170 or PD-1-IN-1) is a first-in-class, potent and orally available small molecule inhibitor of the immune checkpoint regulatory proteins PD-L1 …

JBI-802 BY JUBILANT

It’s only fair to share… EXAMPLE O=C(OC)/C=C/c1ccc(CNC2CC2c2ccc(F)cc2)cc1 EXAMPLE ONLY JBI-802 Myeloid Leukemia Therapy Solid Tumors Therapy Epigenetic Modifier Modulators Histone Deacetylase 6 (HDAC6) Inhibitors Lysine-Specific Histone Demethylase 1A (KDM1A; LSD1) Inhibitors   Jubilant Therapeutics Announces Successful Completion of Pre-IND Meeting with FDA for its Novel Dual LSD1 and HDAC6 Inhibitor JB1-802 https://markets.businessinsider.com/news/stocks/jubilant-therapeutics-announces-successful-completion-of-pre-ind-meeting-with-fda-for-its-novel-dual-lsd1-and-hdac6-inhibitor-jb1-802-1030834551 PRESS RELEASE PR …

Mobocertinib

It’s only fair to share… Mobocertinib 1847461-43-1 MF C32H39N7O4 MW 585.70 propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate TAK-788, AP32788, TAK788, UNII-39HBQ4A67L, AP-32788, 39HBQ4A67L US10227342, Example 10, MFCD32669806, NSC825519, s6813, TAK-788;AP32788, WHO 11183 NSC-825519, example 94 [WO2015195228A1], GTPL10468, BDBM368374, BCP31045, EX-A3392 US FDA APPROVED 9/15/2021, Exkivity, To treat locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutation   Mobocertinib succinate Chemical Structure CAS No. : 2389149-74-8 Molecular Weight 703.78 Formula C₃₆H₄₅N₇O₈ Mobocertinib …

SY 5609

It’s only fair to share… [ Fig. 0001] [ Fig. 0002] [ Fig. 0003] [ Fig. 0004]  https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016058544&tab=FULLTEXT&_cid=P10-KTPTVL-74436-1 SY 5609 CAS 2519828-12-5 Cancer, solid tumor PHASE 1 A highly selective and potent oral inhibitor of cyclin-dependent kinase 7 (CDK7) for potential treatment of advanced solid tumors that harbor the Rb pa thway alterations (Syros Pharmaceuticals, Inc., Cambridge, Massachusetts, USA) …