Tag «CILOFEXOR»

CILOFEXOR

It’s only fair to share…   CILOFEXOR C28H22Cl3N3O5 , 586.8 g/mol 1418274-28-8 GS-9674, Cilofexor (GS(c)\9674) UNII-YUN2306954 YUN2306954 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid Cilofexor is under investigation in clinical trial NCT02943447 (Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis). Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. …