It’s only fair to share… Donidalorsen CAS 2304692-48-4 분자량 Mw 8672.64 화학식Mf C296H435N83O151P20S15 ISIS 721744, ISIS-721744 FDA 8/21/2025, Dawnzera, To prevent attacks of hereditary angioedema DNA, D((2′-O-(2-METHOXYETHYL))M5RU-SP-(2′-O-(2-METHOXYETHYL))RG-SP-(2′-O-(2-METHOXYETHYL))M5RC-(2′-O-(2-METHOXYETHYL))RA-(2′-O-(2-METHOXYETHYL))RA-SP-G-SP-T-SP-M5C-SP-T-SP-M5C-SP-T-SP-T-SP-G-SP-G-SP-M5C-SP-(2′-O-(2-METHOXYETHYL))RA-(2′-O-(2-METHOXYETHYL) Ingredient UNII CAS . Donidalorsen sodium Y30VEG5PH1 2304701-45-7 Donidalorsen, sold under the brand name Dawnzera, is a medication used to prevent attacks of hereditary angioedema.[1] Donidalorsen is a prekallikrein-directed antisense oligonucleotide.[1] It is given by injection under …
Tag «FDA 2025»
Brensocatib
It’s only fair to share… Brensocatib WeightAverage: 420.469Monoisotopic: 420.179755269 Chemical FormulaC23H24N4O4 (2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide FDA 8/12/2025. Brinsupri, To treat non-cystic fibrosis bronchiectasis Brensocatib is an investigational new drug that is being evaluated to treat bronchiectasis.[1] It is a dipeptidyl-peptidase I (also known as cathepsin C) inhibitor.[2] A phase 3 clinical trial, known as the ASPEN trial, was conducted to evaluate the safety and efficacy of …
Dordaviprone
It’s only fair to share… Dordaviprone WeightAverage: 386.499Monoisotopic: 386.210661473 Chemical FormulaC24H26N4O 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one Product Ingredients Ingredient UNII CAS InChI Key Dordaviprone dihydrochloride 53VG71J90J 1638178-82-1 Not applicable FDA 8/6/2025, Modeyso, To treat diffuse midline glioma harboring an H3 K27M mutation with progressive disease following prior therapy Dordaviprone, sold under the brand name Modeyso is an anti-cancer medication used for the treatment …
Zongertinib
It’s only fair to share… Zongertinib CAS No. : 2728667-27-2, BI-1810631, BI1810631 Molecular Weight 535.60 Formula C29H29N9O2 FDA 8/8/2025, Hernexeos, To treat adults with unresectable or metastatic non-squamous non-small cell lung cancer whose tumors have HER2 tyrosine kinase domain activating mutations, as detected by an FDA-approved test, and who have received prior systemic therapy Zongertinib is …
Aceclidine
It’s only fair to share… Aceclidine WeightAverage: 169.224Monoisotopic: 169.110278727 Chemical FormulaC9H15NO2 CAS 827-61-2, 3-Acetoxyquinuclidine, 3-Quinuclidinol acetate (ester), Aceclidina, 0578K3ELIO APROVAL 7/31/2025, Vizz. To treat presbyopia 1-azabicyclo[2.2.2]octan-3-yl acetate Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester(aceclidine) MW: 169.22 MF: C9H15NO2LD50: 78 mg/kg (M, i.p.); 36 mg/kg (M, i.v.); 165 mg/kg (M, p.o.); 102 mg/kg (M, s.c.);45 mg/kg (R, i.v.); 225 …
Sepiapterin
It’s only fair to share… Sepiapterin 17094-01-8 Molecular Weight 237.22 Formula C9H11N5O3 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-3H-pteridin-4-one (S)-2-Amino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one 7/28/2025 fda approved, Sephience, To treat hyperphenylalaninemia in patients with sepiapterin-responsive phenylketonuria, in conjunction with a phenylalanine-restricted diet Sepiapterin, sold under the brand name Sephience, is a medication used for the treatment of hyperphenylalaninemia.[2][3] Sepiapterin is a phenylalanine hydroxylase activator.[1] The most common side effects are upper respiratory …
Sebetralstat
It’s only fair to share… Sebetralstat, KVD 900 CAS 1933514-13-6 491.5 g/mol O5ZD2TU2B7 FDA 7/3/2025, Ekterly, To treat acute attacks of hereditary angioedema N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxopyridin-1-yl)methyl]phenyl]methyl]pyrazole-4-carboxamide Sebetralstat, sold under the brand name Ekterly, is a medication used for the treatment of hereditary angioedema.[1] Sebetralstat is a plasma kallikrein inhibitor.[1] Sebetralstat was approved for medical use in the United States in July 2025.[1][2] SYN https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00921 aReagents …
Sunvozertinib
It’s only fair to share… Sunvozertinib CAS 2370013-12-8 DZD9008, 584.1 g/mol, C29H35ClFN7O3, A-1801, L1Q2K5JYO8 N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide FDA Zegfrovy, 7/2/2025 To treat locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations, as detected by an FDA-approved test, with disease progression on or after platinum-based chemotherapy Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, …
ATRASENTAN
It’s only fair to share… Atrasentan A-147627, (+)-A-127722, ABT-627,173937-91-2, (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid Endothelin ET-A antagonist Diabetic nephropathy; End stage renal disease; Renal disease FDA APPROVED 4/02/2025, Vanrafia, To reduce proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression 1-(N,N-Dibutylcarbamoylmethyl)-2(R)-(4-methoxyphenyl)-4(S)-(3,4-methylenedioxyphenyl)pyrrolidine-3(R)-carboxylic acid (2R,3R,4S)-(+)-2-(4-Methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N,N-di(n-butyl)aminocarbonylmethyl)pyrrolidine-3-carboxylic acid (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N,N-di(n-butyl)aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid C29H38N2O6, 510.631 Ingredient UNII CAS InChI Key …
Taletrectinib
It’s only fair to share… Taletrectinib CAS 1505514-27-1 as salt: 1505515-69-4, Taletrectinib adipate FDA 6/11/2025, Ibtrozi, To treat locally advanced or metastatic ROS1-positive non-small cell lung cancer, ALSO CHINA 2024 AB-106, DS-6051a 405.5 g/mol, C23H24FN5O, UNII-W4141180YD 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine Taletrectinib adipate WeightAverage: 551.619Monoisotopic: 551.254397378 Chemical FormulaC29H34FN5O5 DS-6051B, CAS 1505515-69-4, 6KLL51GNBG, 3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine; hexanedioic acid Taletrectinib, sold under the brand name Ibtrozi, …