It’s only fair to share… New Website goflow.at online! C. Oliver Kappe Professor at University of Graz Institute of Chemistry Univ.-Prof. Mag. Dr.rer.nat. +43 316 380-5352 +43 (0) 316 380 – 9840 Oliver.kappe (at) uni-graz.at Research in the Kappe lab focuses on flow chemistry, microreactor technology, process intensification and the continuous generation of active pharmaceutical ingredients …
Tag «FLOW CHEMISTRY»
Continuous Flow Stereoselective Synthesis of (S)-Warfarin
It’s only fair to share… Continuous Flow Stereoselective Synthesis of (S)-Warfarin The same catalytic packed-bed reactor was used for the preparation of (S)-warfarin 107 under continuous flow conditions (Scheme ).A solution of 4-OH-coumarin 104, benzalacetone105, and trifluoroacetic acid as a cocatalyst in dioxane was flowed into the reactor containing the polystyrene-supported 9-amino-epi-quinine 122. With a …
Diphenhydramine Hydrochloride, Use of Flow Synthesis
It’s only fair to share… Diphenhydramine Hydrochloride REGULAR SYNTHESIS FLOW SYNTHESIS Diphenhydramine hydrochloride is the active pharmaceutical ingredient in several widely used medications (e.g., Benadryl, Zzzquil, Tylenol PM, Unisom), and its worldwide demand is higher than 100 tons/year. In 2013, Jamison and co-workers developed a continuous flow process for the synthesis of 3 minimizing waste …