Tag «JAPAN 2019»

Beperminogene perplasmid, ベペルミノゲンペルプラスミド

It’s only fair to share… 1gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga 51ctagttatta atagtaatca attacggggt cattagttca tagcccatat 101atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc 151gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag 201taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg 251taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 301ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt 351acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc 401atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg 451atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca …

Ferric carboxymaltose , カルボキシマルトース第二鉄

It’s only fair to share… Ferric carboxymaltose カルボキシマルトース第二鉄 CAS: 9007-72-1 Molecular Formula, C24H44FeO25– Molecular Weight, 788.43616  g/mol (2S,3S,4S,5R)-4-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate Iron dextri-maltose Iron(3+) hydroxide oxide poly-(1–4)-alpha-D-glucopyranosyl-(1–4)-D-gluconate hydrate Polynuclear iron (III)-hydroxide 4(R)-(poly-(1–4)-O-alpha-D-glucopyranosyl)-oxy-2(R),3(S),5(R),6-tetrahydroxy-hexanoate Poly[D-glucopyranosyl(1–4)]-D-gluconic acid complex of hydrated iron(III) oxide japan pmda approved, 2019/3/26, Ferinject Treatment of patients with iron deficiency anemia Hematinic, Supplement (iron) LAUNCHED, 2007, Vifor Pharma, Anemia, iron deficiency 1 Injectafer 2. Ferinject 3. Iron Dextri-maltose …

Thiotepa, チオテパ ,тиотепа , ثيوتيبا , 塞替派 ,

It’s only fair to share…   Thiotepa, チオテパ Use:antineoplastic, alkylating agent Chemical name:1,1′,1”-phosphinothioylidynetrisaziridine Formula:C6H12N3PS MW:189.22 g/mol CAS:52-24-4 EINECS:200-135-7 LD50:14500 μg/kg (M, i.v.); 38 mg/kg (M, p.o.); 9400 μg/kg (R, i.v.) Aziridine, 1,1′,1”-phosphinothioylidynetris- Aziridine, 1-[bis(1-aziridinyl)phosphinothioyl]- N,N’,N”-Triethylenethiophosphoramide Phosphorothioic tri(ethyleneamide) SZ2975000 T3NTJ APS&- AT3NTJ&– AT3NTJ [WLN] Thiofozil Thiotef 1,1′,1”-Phosphorothioyltriaziridine JAPAN APPROVED, Rethio, PMDA, 2019/3/26 тиотепа [Russian] [INN] ثيوتيبا [Arabic] [INN] 塞替派 [Chinese] [INN] Thiotepa (INN,[1] chemical name: N,N′,N′′-triethylenethiophosphoramide) is an alkylating agent used …

Peficitinib hydrobromide, ペフィシチニブ臭化水素酸塩

It’s only fair to share… Peficitinib hydrobromide ペフィシチニブ臭化水素酸塩 ASP015K, Rheumatoid Arthritis 1H-Pyrrolo(2,3-b)pyridine-5-carboxamide, 4-((5-hydroxytricyclo(3.3.1.13,7)dec-2-yl)amino)-, hydrobromide (1:1), stereoisomer 4-{[(1R,2s,3S,5r)-5-Hydroxyadamantan-2-yl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide (1:1) 1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[[(1R,3S)-5-hydroxytricyclo[3.3.1.13,7]dec-2-yl]amino]-, hydrobromide (1:1) U55XHZ5X6P Formula C18H22N4O2. HBr CAS 1353219-05-2 HBR 944118-01-8 BASE Mol weight 407.3048 PMDA, 2019/3/26 JAPAN APPROVED, Smyraf Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis Peficitinib (formerly known as ASP015K) is …

Romosozumab, ロモソズマブ (遺伝子組換え)

It’s only fair to share… Romosozumab ロモソズマブ (遺伝子組換え) AMG 785 Immunoglobulin G2, anti-(human sclerostin) (human-mouse monoclonal 785A070802 heavy chain), disulfide with human-mouse monoclonal 785A070802 κ-chain, dimer Immunoglobulin G2, anti-(human sclerostin) (humanized monoclonal 785A070802 heavy chain), disulfide with humanized monoclonal 785A070802 κ-chain, dimer Formula C6452H9926N1714O2040S54 CAS 909395-70-6 Mol weight 145875.6186 Monoclonal antibody Treatment of osteoporosis Osteoporosis …

Nalmefene hydrochloride dihydrate, ナルメフェン塩酸塩水和物 ,

It’s only fair to share… Nalmefene hydrochloride dihydrate, ナルメフェン塩酸塩水和物 2019/1/8, PMDA, JAPAN, Selincro, In January 2019, Otsuka received regulatory approval in Japan Antialcohol dependence, Narcotic antagonist, Opioid receptor partial agonist/antagonist Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, hydrate (1:1:2), (5α)- Formula C21H25NO3. HCl. 2H2O CAS 1228646-70-5 5096-26-9 free form 58895-64-0 (Nalmefene HCl) Mol weight 411.9196   JF-1; NIH-10365; ORF-11676; SRD-174, Lu-AA36143 APPROVED 1995 USA Trade …

Esaxerenone エサキセレノン , эсаксеренон , إيساكسيرينون , 艾沙利 酮 ,

It’s only fair to share… Esaxerenone エサキセレノン , эсаксеренон , إيساكسيرينون , 艾沙利  酮 ,  CS-3150, XL-550 Formula C22H21F3N2O4S CAS 1632006-28-0 Mol weight 466.4734 Pmda approved japan, 2019/1/8, Minebro Antihypertensive, Aldosterone antagonist N62TGJ04A1 UNII:N62TGJ04A1 эсаксеренон [Russian] [INN] إيساكسيرينون [Arabic] [INN] 艾沙利酮 [Chinese] [INN] 1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide 10230 1632006-28-0 [RN], 880780-76-7, 1072195-82-4 (+ isomer)   1072195-83-5 (- isomer) 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]- Originator X-Ceptor Therapeutics Developer Daiichi Sankyo Company Class Antihyperglycaemics; Antihypertensives; Pyrroles; Small molecules; Sulfones Mechanism of Action Mineralocorticoid receptor antagonists …

Relugolix レルゴリクス

It’s only fair to share…   Relugolix (TAK-385), RVT 601 レルゴリクス Formula C29H27F2N7O5S CAS 737789-87-6 Mol weight UNII 623.6304 UNII-P76B05O5V6 2019/1/8  PMDA JAPAN APPROVED, Relumina 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N’-methoxy-  737789-87-6 [RN] 9628 P76B05O5V6 Originator Takeda Developer Myovant Sciences; Takeda; Takeda Oncology Class Analgesics; Antineoplastics; Ketones; Pyrimidines; Small molecules Mechanism of Action LHRH receptor antagonists Preregistration Uterine leiomyoma Phase III Pain; Prostate cancer No development reported Solid …

Metyrosine, Metirosine メチロシン метирозин , ميتيروسين , 甲酪氨酸 ,

It’s only fair to share…   Metyrosine, Metirosine メチロシン  метирозин , ميتيروسين , 甲酪氨酸 ,  Metyrosine (USP); Metirosine (JAN/INN); Demser (TN) CAS 672-87-7 Molecular FormulaC10H13NO3 Average mass195.215 Da APPROVED P[MDA JAPAN 2019/1/8 (-)-alpha-Methyl-L-tyrosine (–)-α-methyl-L-tyrosine (S)-alpha-Methyltyrosine Methyltyrosine Synthesis ReferenceUS2868818 α-Methyl-p-tyrosine метирозин [Russian] [INN] ميتيروسين [Arabic] [INN] 甲酪氨酸 [Chinese] [INN] (-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure (-)-α-Methyl-L-tyrosine (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid 211-599-5 [EINECS] 3929 672-87-7 [RN] a-Methyl-3-(p-hydroxyphenyl)alanine a-methyl-L-tyrosine a-Methyl-p-tyrosine a-MPT Demser [Trade name] DOQ0J0TPF7 L 588357-0 L-2-Methyl-3-(4-hydroxyphenyl)alanine L-a-MT L-tyrosine, a-methyl- OPTICAL RoT -0.24 …