Tag «JAPAN 2019»

Romosozumab, ロモソズマブ (遺伝子組換え)

It’s only fair to share… Romosozumab ロモソズマブ (遺伝子組換え) AMG 785 Immunoglobulin G2, anti-(human sclerostin) (human-mouse monoclonal 785A070802 heavy chain), disulfide with human-mouse monoclonal 785A070802 κ-chain, dimer Immunoglobulin G2, anti-(human sclerostin) (humanized monoclonal 785A070802 heavy chain), disulfide with humanized monoclonal 785A070802 κ-chain, dimer Formula C6452H9926N1714O2040S54 CAS 909395-70-6 Mol weight 145875.6186 Monoclonal antibody Treatment of osteoporosis Osteoporosis …

Nalmefene hydrochloride dihydrate, ナルメフェン塩酸塩水和物 ,

It’s only fair to share… Nalmefene hydrochloride dihydrate, ナルメフェン塩酸塩水和物 2019/1/8, PMDA, JAPAN, Selincro, In January 2019, Otsuka received regulatory approval in Japan Antialcohol dependence, Narcotic antagonist, Opioid receptor partial agonist/antagonist Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, hydrate (1:1:2), (5α)- Formula C21H25NO3. HCl. 2H2O CAS 1228646-70-5 5096-26-9 free form 58895-64-0 (Nalmefene HCl) Mol weight 411.9196   JF-1; NIH-10365; ORF-11676; SRD-174, Lu-AA36143 APPROVED 1995 USA Trade …

Esaxerenone エサキセレノン , эсаксеренон , إيساكسيرينون , 艾沙利 酮 ,

It’s only fair to share… Esaxerenone エサキセレノン , эсаксеренон , إيساكسيرينون , 艾沙利  酮 ,  CS-3150, XL-550 Formula C22H21F3N2O4S CAS 1632006-28-0 Mol weight 466.4734 Pmda approved japan, 2019/1/8, Minebro Antihypertensive, Aldosterone antagonist N62TGJ04A1 UNII:N62TGJ04A1 эсаксеренон [Russian] [INN] إيساكسيرينون [Arabic] [INN] 艾沙利酮 [Chinese] [INN] 1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide 10230 1632006-28-0 [RN], 880780-76-7, 1072195-82-4 (+ isomer)   1072195-83-5 (- isomer) 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]- Originator X-Ceptor Therapeutics Developer Daiichi Sankyo Company Class Antihyperglycaemics; Antihypertensives; Pyrroles; Small molecules; Sulfones Mechanism of Action Mineralocorticoid receptor antagonists …

Relugolix レルゴリクス

It’s only fair to share…   Relugolix (TAK-385), RVT 601 レルゴリクス Formula C29H27F2N7O5S CAS 737789-87-6 Mol weight UNII 623.6304 UNII-P76B05O5V6 2019/1/8  PMDA JAPAN APPROVED, Relumina 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N’-methoxy-  737789-87-6 [RN] 9628 P76B05O5V6 Originator Takeda Developer Myovant Sciences; Takeda; Takeda Oncology Class Analgesics; Antineoplastics; Ketones; Pyrimidines; Small molecules Mechanism of Action LHRH receptor antagonists Preregistration Uterine leiomyoma Phase III Pain; Prostate cancer No development reported Solid …

Metyrosine, Metirosine メチロシン метирозин , ميتيروسين , 甲酪氨酸 ,

It’s only fair to share…   Metyrosine, Metirosine メチロシン  метирозин , ميتيروسين , 甲酪氨酸 ,  Metyrosine (USP); Metirosine (JAN/INN); Demser (TN) CAS 672-87-7 Molecular FormulaC10H13NO3 Average mass195.215 Da APPROVED P[MDA JAPAN 2019/1/8 (-)-alpha-Methyl-L-tyrosine (–)-α-methyl-L-tyrosine (S)-alpha-Methyltyrosine Methyltyrosine Synthesis ReferenceUS2868818 α-Methyl-p-tyrosine метирозин [Russian] [INN] ميتيروسين [Arabic] [INN] 甲酪氨酸 [Chinese] [INN] (-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure (-)-α-Methyl-L-tyrosine (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid 211-599-5 [EINECS] 3929 672-87-7 [RN] a-Methyl-3-(p-hydroxyphenyl)alanine a-methyl-L-tyrosine a-Methyl-p-tyrosine a-MPT Demser [Trade name] DOQ0J0TPF7 L 588357-0 L-2-Methyl-3-(4-hydroxyphenyl)alanine L-a-MT L-tyrosine, a-methyl- OPTICAL RoT -0.24 …