APPROVALS 2024 – Page 5 – Drug Approvals International

Berdazimer

It’s only fair to share… Berdazimer 1846565-00-1 CAS NA SALT, 1846565-00-1 FDA APPROVE 1 /5/2024, To treat molluscum contagiosum Drug Trials Snapshot NVN-1000 free acid NVN1000 free acid Silsesquioxanes, 3-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)propyl 3-(methylamino)propyl, polymers with silicic acid (h4sio4) tetra-et ester, hydroxy-terminated Berdazimer sodium, sold under the brand name Zelsuvmi, is a medication used for the treatment for molluscum contagiosum.[1] Berdazimer sodium is a nitric …

Tovorafenib

It’s only fair to share… Tovorafenib 506.29 C17H12Cl2F3N7O2S 1096708-71-2 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide 4/23/2024 FDA APROVED, To treat relapsed or refractory pediatric low-grade glioma, Ojemda AMG 2112819 BIIB 024 BIIB-024 BIIB024 DAY 101 DAY-101 DAY101 MLN 2480 MLN-2480 MLN2480 TAK 580 TAK-580 TAK580 Tovorafenib, sold under the brand name Ojemda, is a medication used for the treatment of glioma.[1] It is a kinase inhibitor.[1] …

Ceftobiprole

It’s only fair to share… C20H22N8O6S2 534.57 209467-52-7 (6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(N-hydroxyimino)acetamido]-8-oxo-3-{[(3E,3’R)-2-oxo-[1,3′-bipyrrolidin]-3-ylidene]methyl}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid BAL-9141 BAL-9141-000 BAL-9141000 BAL9141-000 RO 63-9141 RO-63-9141 RO-639141 ceftobiprole medocaril sodium Ro-655788 BAL-5788-001 Molecular Weight 712.64 Formula C26H25N8NaO11S2 CAS No. 252188-71-9 Appearance Solid Color Off-white to light yellow SMILES O=C(C(N(C1=O)[C@@](SC2)([H])[C@@H]1NC(/C(C3=NSC(N)=N3)=N\O)=O)=C2/C=C(CCN4[C@@](CC5)([H])CN5C(OCC(OC6=O)=C(O6)C)=O)/C4=O)O[Na] fda approved 4/3/2024, To treat certain bloodstream infections, bacterial skin and associated tissue infections, and community-acquired bacterial …

Danicopan

It’s only fair to share… Danicopan USFDA 3/29/2024, To treat extravascular hemolysis with paroxysmal nocturnal hemoglobinuria, Voydeya C26H23BrFN7O3 580.418 1903768-17-1 (2S,4R)-1-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide ACH 0144471 ACH-4471 ACH0144471 ALXN 2040 ALXN-2040 ALXN2040 Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria.[2] It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and …

ARIMOCLOMOL

It’s only fair to share… ARIMOCLOMOL アリモクロモル; Formula C14H20ClN3O3 Exact mass 313.1193 Mol weight 313.7799 CAS 289893-25-0 289893-26-1 (Arimoclomol maleate); INN 8300 N-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy]-1-oxidopyridin-1-ium-3-carboximidoyl chloride BRX 220 FDA APPROVED, 9/20/2024, Miplyffa, To treat Niemann-Pick disease type C Press Release Drug Trials Snapshot Arimoclomol maleate is in a phase III clinical trials by Orphazyme for the treatment of …

Rezivertinib

It’s only fair to share… BPI-7711, Rezivertinib 1835667-12-3 C27H30N6O3, 486.576 N-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide Beta Pharma in collaboration Chinese licensee CSPC Pharmaceuticals Group , is developing BPI-7711 In June 2021, this drug was reported to be in phase 3 clinical development. APPROVALS 2024, CHINA 2024 OriginatorBeta Pharma ClassAmides; Amines; Antineoplastics; Indoles; Phenyl ethers; Pyrimidines; Small molecules Mechanism of ActionEpidermal …

Xanomeline (LY-246,708; Lumeron, Memcor) ксаномелин , كسانوميلين , 诺美林 ,

It’s only fair to share… Xanomeline (LY-246,708; Lumeron, Memcor) CAS 131986-45-3 Molecular FormulaC14H23N3OS Average mass281.417 Da ксаномелин , كسانوميلين , 诺美林 , Hexyloxy-TZTP 5-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1-méthyl-1,2,3,6-tétrahydropyridine Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl- Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. in vitro: Xanomeline had high affinity for muscarinic receptors in brain homogenates, but had substantially less or no affinity for a number …

RPL 554, Ensifentrine

It’s only fair to share… RPL-554, Ensifentrine Molecular FormulaC26H31N5O4 Average mass477.555 FDA 6/26/2024, Ohtuvayre, To treat chronic obstructive pulmonary disease Drug Trials Snapshot RPL 554 Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]- (2-[(2E)-9,10-DIMETHOXY-4-OXO-2-[(2,4,6-TRIMETHYLPHENYL)IMINO]-2H,3H,4H,6H,7H-PYRIMIDO[4,3-A]ISOQUINOLIN-3-YL]ETHYL)UREA 2-[9,10-dimethoxy-4-oxo-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-3-yl]ethylurea {2-[(2E)-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H,3H,4H,6H,7H-pyrimido[4,3-a]isoquinolin-3-yl]ethyl}urea 2-[4-keto-9,10-dimethoxy-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[4,3-a]isoquinolin-3-yl]ethylurea 2-[9,10-dimethoxy-4-oxo-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[4,3-a]isoquinolin-3-yl]ethylurea 298680-25-8 CAS UNII:3E3D8T1GIX CFTR stimulator; PDE 3 inhibitor; PDE 4 inhibitor RPL-554 is a mixed phosphodiesterase (PDE) III/IV inhibitor in phase II clinical development …