Category «PHASE 3»

BINDARIT

It’s only fair to share…   BINDARIT Molecular FormulaC19H20N2O3 Average mass324.374 Da CAS 130641-38-2 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid 2-[(1 -benzyl-1 H-indazol-3-yl)methoxy]-2-methylpropanoic acid 2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid JQ11LH711M Propanoic acid, 2-methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]- [ACD/Index Name] биндарит [Russian] [INN] بينداريت [Arabic] [INN] 宾达利 [Chinese] [INN] PHASE 2 Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Bindarit, an inhibitor of monocyte chemotactic protein …

Roluperidone

It’s only fair to share… Molecular FormulaC22H23FN2O2 Average mass366.429 Da Roluperidone CAS 359625-79-9 1937215-88-7 hcl ролуперидон [Russian] [INN] رولوبيريدون [Arabic] [INN] 罗鲁哌酮 [Chinese] [INN] 1H-Isoindol-1-one, 2-[[1-[2-(4-fluorophenyl)-2-oxoethyl]-4-piperidinyl]methyl]-2,3-dihydro- 2-({1-[2-(4-Fluorophenyl)-2-oxoethyl]-4-piperidinyl}methyl)-1-isoindolinone 2-[[1- [2–fluorophenyl) -2-oxotyl] piperidine –4-yl] methyl] isoindrin-hydrochloride CYR-101 UNII-4P31I0M3BF MIN-101 SYN Roluperidone (former developmental code names MIN-101, CYR-101, MT-210) is a 5-HT2A and σ2 receptor antagonist that is under development by Minerva Neurosciences for the treatment of schizophrenia.[1][2][3][4] One of its metabolites also has some affinity for the H1 receptor.[2] As of May 2018, the …

REPROXALAP

It’s only fair to share… REPROXALAP レプロキサラップ; ADX-102 2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol C12H13ClN2O, 236.7 g/mol CAS 916056-79-6 UNII-F0GIZ22IJH 2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol Phase 3 Clinical Aldeyra Therapeutics is developing reproxalap, which binds and traps free aldehydes, formulated using Captisol technology licensed from Ligand Pharmaceuticals as an eye drop formulation, for treating acute noninfectious anterior uveitis, allergic conjunctivitis and dry eye syndrome.   PATENT …

Odevixibat

It’s only fair to share… Odevixibat A-4250, AR-H 064974 CAS 501692-44-0 BUTANOIC ACID, 2-(((2R)-2-((2-((3,3-DIBUTYL-2,3,4,5-TETRAHYDRO-7-(METHYLTHIO)-1,1-DIOXIDO-5-PHENYL-1,2,5-BENZOTHIADIAZEPIN-8-YL)OXY)ACETYL)AMINO)-2-(4-HYDROXYPHENYL)ACETYL)AMINO)-, (2S)- (2S)-2-[[(2R)-2-[[2-[(3,3-dibutyl-7-methylsulfanyl-1,1-dioxo-5-phenyl-2,4-dihydro-1λ6,2,5-benzothiadiazepin-8-yl)oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]butanoic acid Molecular Formula C37H48N4O8S2 Molecular Weight 740.929 AZD8294WHO 10706AR-H064974HY-109120CS-0078340D11716US9694018, 5Originator Albireo AB Developer Albireo AB; Albireo Pharma ClassAcetamides; Butyric acids; Hepatoprotectants; Small molecules; Sulfones; Thiazepines Mechanism of Action Sodium-bile acid cotransporter inhibitors Orphan Drug Status Yes – Primary biliary cirrhosis; Biliary atresia; Intrahepatic cholestasis; Alagille …

CILOFEXOR

It’s only fair to share…   CILOFEXOR C28H22Cl3N3O5 , 586.8 g/mol 1418274-28-8 GS-9674, Cilofexor (GS(c)\9674) UNII-YUN2306954 YUN2306954 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid Cilofexor is under investigation in clinical trial NCT02943447 (Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis). Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. …

Remdesivir, レムデシビル , ремдесивир , ريمديسيفير , 瑞德西韦 ,

It’s only fair to share…   Remdesivir Formula C27H35N6O8P CAS 1809249-37-3 Mol weight 602.576 レムデシビル UNII:3QKI37EEHE ремдесивир [Russian] [INN] ريمديسيفير [Arabic] [INN] 瑞德西韦 [Chinese] [INN] 2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) L-Alanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile 2-Ethylbutyl (2S)-2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate 2-Ethylbutyl (2S)-2-[[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate 2-Ethylbutyl N-[(S)-[2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitril-6-O-yl]phenoxyphosphoryl]-L-alaninate GS 5734 L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester,6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile GS-5734 Treatment of viral infections Phase III, clinical trials for the treatment …

RESMETIROM

It’s only fair to share… RESMETIROM C17H12Cl2N6O4 435.2 g/mol MGL-3196 CAS 920509-32-6, Resmetirom, VIA-3196, UNII-RE0V0T1ES0 Phase III, Non-alcoholic fatty liver disease (NAFLD) 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile 2-(3,5-DICHLORO-4-((5-ISOPROPYL-6-OXO-1,6-DIHYDROPYRIDAZIN-3-YL)OXY)PHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-(1,2,4)TRIAZINE-6-CARBONITRILE 1,2,4-TRIAZINE-6-CARBONITRILE, 2-(3,5-DICHLORO-4-((1,6-DIHYDRO-5-(1-METHYLETHYL)-6-OXO-3-PYRIDAZINYL)OXY)PHENYL)-2,3,4,5-TETRAHYDRO-3,5-DIOXO- Madrigal Pharmaceuticals , following the merger between Synta and Madrigal Pharmaceuticals (pre-merger) (following the acquisition of  VIA Pharmaceuticals ‘ assets (originally under license from  Roche )), is developing resmetirom (MGL-3196, VIA-3196), the lead from oral …

Coblopasvir

It’s only fair to share… Coblopasvir CAS: 1312608-46-0 Chemical Formula: C41H50N8O8 Molecular Weight: 782.89 UNII-67XWL3R65W methyl {(2S)-1-[(2S)-2-(4-{4-[7-(2-[(2S)-1-{(2S)-2- [(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl)-2H-1,3-benzodioxol-4-yl]phenyl}-1Himidazol-2-yl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate Carbamic acid, N-((1S)-1-(((2S)-2-(5-(4-(7-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-1,3-benzodioxol-4-yl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)-, methyl ester hepatitis C virus infection KW-136 Coblopasvir is an antiviral drug candidate. Coblopasvir dihydrochloride CAS 1966138-53-3 C41 H50 N8 O8 . 2 Cl H  Molecular Weight 855.806 PHASE 3 Beijing Kawin Technology Share-Holding Hepatitis …

Azeliragon

It’s only fair to share… Azeliragon C32H38ClN3O2, 532.1 g/mol CAS 603148-36-3 TTP488 UNII-LPU25F15UQ LPU25F15UQ TTP-488; PF-04494700 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine MOA:RAGE inhibitor Indication:Alzheimer’s disease (AD) Status:Phase III (Active), Dementia, Alzheimer’s type Company:vTv Therapeutics (Originator) Azeliragon Azeliragon is in phase III clinical for the treatment of Alzheimer’s type dementia. Azeliragon was originally by TransTech Pharma (now vTv Therapeutics), then licensed to Pfizer in …

Benvitimod, Tapinarof, тапинароф , تابيناروف , 他匹那罗 ,

It’s only fair to share… Benvitimod, Tapinarof 3,5-dihydroxy-4-isopropyl-trans-stilbene Launched – 2019 CHINA, Psoriasis, Tianji Pharma тапинароф [Russian] [INN]WBI-1001 تابيناروف [Arabic] [INN] 他匹那罗 [Chinese] [INN] (E)-2-(1-Methylethyl)-5-(2-phenylethenyl)-1,3-benzenediol 1,3-Benzenediol, 2-(1-methylethyl)-5-(2-phenylethenyl)-, (E)- 1,3-Benzenediol, 2-(1-methylethyl)-5-[(E)-2-phenylethenyl]- 10253 2-Isopropyl-5-[(E)-2-phenylvinyl]-1,3-benzenediol 3,5-Dihydroxy-4-isopropyl-trans-stilbene 5-[(E)-2-phenylethenyl]-2-(propan-2-yl)benzene-1,3-diol 79338-84-4 [RN] 84HW7D0V04 Research Code:WB-1001; WBI-1001 Trade Name:MOA:NSAID Indication:Atopic dermatitis; PsoriasisStatus: Phase III (Active) Company:GlaxoSmithKline (Originator), Welichem Biotech (Originator), 天济药业 (Originator) 2894512 DMVT-505 GSK-2894512 RVT-505 WB-1001 WBI-1001 84HW7D0V04 (UNII code) In May 2019, the drug …