Category «PHASE 3»

VADADUSTAT

It’s only fair to share… VADADUSTAT AKB-6548, PG-1016548 PG1016548, UNII:I60W9520VV, B-506 CAS 1000025-07-9 [5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxamido]acetic acid N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine MF C14H11ClN2O4 , 306.0407 Inventors Richard Kawamoto Original Assignee The Procter & Gamble Company for Treatment of Anemia associated with Chronic Kidney Disease (CKD) Originator Procter & Gamble Developer Akebia Therapeutics Class Antianaemics; Chlorophenols; Pyridines; Small molecules Mechanism of Action Hypoxia-inducible factor-proline dioxygenase inhibitors Phase III Anaemia …

Evofosfamide, эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 ,

It’s only fair to share…   Evofosfamide, HAP-302 , TH-302, TH 302 эвофосфамид ,  إيفوفوسفاميد ,  艾伏磷酰胺 , Molecular Formula C9H16Br2N5O4P Average mass 449.036 Da (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N’-bis(2-bromoethyl)phosphorodiamidate (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl-N,N’-bis(2-bromethyl)phosphorodiamidat 918633-87-1 TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs Originator Threshold Pharmaceuticals Developer Merck KGaA; Threshold Pharmaceuticals Class Antineoplastics; Nitroimidazoles; Phosphoramide mustards; Small …