Category «Uncategorized»

Abikoviromycin

It’s only fair to share… Abikoviromycin Molecular FormulaC10H11NO Average mass161.200 Da CAS Registry Number: 31774-33-1 CAS Name: 7-Ethylidene-1a,2,3,7-tetrahydrocyclopent[b]oxireno[c]pyridine (1aR,7E,7aS)-7-Ethylidene-1a,2,3,7-tetrahydrocyclopenta[b]oxireno[c]pyridine [ACD/IUPAC Name] abikoviromycin Cyclopent(b)oxireno(c)pyridine, 7-ethylidene-1a,2,3,7-tetrahydro-, (1aR,7E,7aS)- Cyclopent[b]oxireno[c]pyridine, 7-ethylidene-1a,2,3,7-tetrahydro-, (1aR,7E,7aS)- Additional Names: 4,4a-epoxy-5-ethylidene-2,3,4,4a-tetrahydro-5H-1-pyridine; abicoviromycin; latumcidin Molecular Formula: C10H11NO Molecular Weight: 161.20 Percent Composition: C 74.51%, H 6.88%, N 8.69%, O 9.93% Literature References: Antiviral antibiotic produced by Streptomyces abikoensis and Streptomyces rubescens. Chromatographic isoln from broth cultures: Umezawa et al., Jpn. …

ブレキサノロン , Brexanolone, Allopregnanolone

It’s only fair to share…   Brexanolone 318.501 g/mol, C21H34O2 CAS: 516-54-1 ブレキサノロン MFCD00003677 Pregnan-20-one, 3-hydroxy-, (3α,5α)- Pregnan-20-one, 3-hydroxy-, (3α,5α)- [ACD/Index Name] S39XZ5QV8Y TU4383000 UNII:S39XZ5QV8Y (1S,2S,7S,11S,14S,15S,5R,10R)-14-acetyl-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0<2,7>.0<11,15>]heptadecane (+)-3a-Hydroxy-5a-pregnan-20-one (+)-3α-Hydroxy-5α-pregnan-20-one (3α,5α)-3-Hydroxypregnan-20-one [ACD/IUPAC Name] 10446 3211363 [Beilstein] 3a-Hydroxy-5a-pregnan-20-one The U.S. Food and Drug Administration today approved Zulresso (brexanolone) injection for intravenous (IV) use for the treatment of postpartum depression (PPD) in adult women. …

Triclabendazole, トリクラベンダゾール

It’s only fair to share…   Triclabendazole トリクラベンダゾール CGA-89317 Formula C14H9Cl3N2OS CAS 68786-66-3 Mol weight 359.6581 Anthelmintic 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole 68786-66-3 [RN] DD6747000 Fasinex [Trade name] MFCD00864519 [MDL number] APPROVED, Egat, FDA 2019, 02/13/2019 Triclabendazole, sold under the brand name Egaten among others, is a medication used to treat liver flukes, specifically fascioliasisand paragonimiasis.[1] It is very effective for both conditions.[1] Treatment in hospital may be required.[1] It is …

ASP 3026

It’s only fair to share… ASP3026 ASP3026; CAS 1097917-15-1; ASP-3026; ASP 3026; UNII-HP4L6MXF10; N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine; 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine (N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine)  was developed as a novel selective inhibitor of the fusion protein EML4-ALK. 1H NMR (CDCl3, 400 MHz) (ppm) = 1.31 (d, 6H, J = 6.8 Hz), 1.58–1.80 (m, 4H), 1.90–2.04 (m, 2H), 2.16–2.84 (m, 12H), 3.18–3.32 (m, 1H), 3.66–3.76 …

Cenobamate

It’s only fair to share… Cenobamate CAS: 913088-80-9 Chemical Formula: C10H10ClN5O2 Molecular Weight: 267.67 Related CAS #: 913088-80-9   913087-59-9 Synonym: YKP-3089; YKP3089; YKP3089; Cenobamate IUPAC/Chemical Name: (R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl carbamate 2H-Tetrazole-2-ethanol, α-(2-chlorophenyl)-, carbamate (ester), (αR)- (9CI) (1R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl carbamate Carbamic acid (R)-(+)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl ester 2H-Tetrazole-2-ethanol, α-(2-chlorophenyl)-, 2-carbamate, (αR)- Cenobamate, also known as YKP-3089, is a novel new antiepileptic drug candidate. Cenobamate showed …

Rovafovir Etalafenamide

It’s only fair to share… Rovafovir etalafenamide GS-9131 UNII-U8S0IC8DY7  ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate L-Alanine, N-((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydro-2-furanyl)oxy)methyl)phenoxyphosphinyl)-, ethyl ester CAS: 912809-27-9 Chemical Formula: C21H24FN6O6P Molecular Weight: 506.43 Originator Gilead Sciences Class Antiretrovirals; Purine nucleosides; Small molecules Mechanism of Action Nucleoside reverse transcriptase inhibitors Phase II HIV-1 infections 03 Apr 2018 Phase-II clinical trials in HIV-1 infections (Treatment-experienced) in Uganda (PO) (NCT03472326) 21 Mar 2018 Gilead …

OLACAFTOR, VX 440

It’s only fair to share… OLACAFTOR, VX 440 CAS 1897384-89-2 Molecular Formula: C29H34FN3O4S Molecular Weight: 539.666 g/mol CFTR corrector; UNII-RZ7027HK8F; RZ7027HK8F; Target-based Actions, CFTR modulator Indications, Cystic fibrosis CS-0044588 UNII-RZ7027HK8F RZ7027HK8F Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, shows the potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of …

Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban

It’s only fair to share… Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban Makoto Michida*† , Hideaki Ishikawa†, Takeshi Kaneda†, Shinya Tatekabe‡, and Yoshitaka Nakamura§ †Process Technology Research Laboratories (PTRL), Daiichi Sankyo Co., Ltd., 1-12-1 Shinomiya, Hiratsuka-shi, Kanagawa 254-0014, Japan ‡Plant Management Department, Daiichi Sankyo Chemical Pharma Co., Ltd., 477 Takada, Odawara-shi, Kanagawa 250-0216, Japan §Global Supply Chain – Technology Function, Daiichi Sankyo, Inc., 211 Mt. Airy …

Viloxazine, ヴィロキサジン;

It’s only fair to share… Viloxazine Molecular FormulaC13H19NO3 Average mass237.295 Da 2-[(2-Ethoxyphenoxy)methyl]morpholine 256-281-7 [EINECS] 3489 46817-91-8 free [RN], Hcl 35604-67-2 5I5Y2789ZF Emovit [Wiki] Morpholine, 2-((2-ethoxyphenoxy)methyl)- Morpholine, 2-[(2-ethoxyphenoxy)methyl]- UNII:5I5Y2789ZF Viloxazine hydrochloride OQW30I1332 35604-67-2 Polymorph FORM A , B US226136693, US2011032013   Viloxazine (trade names Vivalan, Emovit, Vivarint and Vicilan) is a morpholine derivative and is a selective norepinephrine reuptake inhibitor (NRI). It was used as an antidepressant in some European countries, and produced …

Macimorelin acetate

It’s only fair to share… Macimorelin Molecular FormulaC26H30N6O3 Average mass474.555 Da CAS  381231-18-1 Chemical Formula: C26H30N6O3 Exact Mass: 474.23794 Molecular Weight: 474.55480 Elemental Analysis: C, 65.80; H, 6.37; N, 17.71; O, 10.11 2-Methylalanyl-N-[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]-D-tryptophanamide 381231-18-1 [RN] 8680B21W73 9073 D-Tryptophanamide, 2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]- CAS 945212-59-9 (Macimorelin acetate) (2R)-2-(2-amino-2-methylpropanamido)-3-(1H-indol-3-yl)-N-[(1R)-2-(1H-indol-3-yl)-1-formamidoethyl]propanamide; acetic acid AEZS-130 ARD-07 D-87875 EP-01572 EP-1572 JMV-1843 USAN (ab-26) MACIMORELIN ACETATE AQZ1003RMG …