Category «Uncategorized»

BAY 1895344

It’s only fair to share… BAY 1895344 1876467-74-1 (free base) (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridin-2-yl)morpholine, monohydrochloride BAY-1895344 Molecular Weight 411.89 Formula C₂₀H₂₂ClN₇O   BAY-1895344 (hydrochloride) 1876467-74-1 1876467-74-1(free base) s8666, CCG-268786, CS-7574, HY-101566A BAY-1895344 hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity. NMR https://file.selleckchem.com/downloads/nmr/S866603-BAY-1895344-hnmr-selleck.pdf   Biological Activity In vitro, BAY 1895344 was shown to be a very potent and highly …

MK 5204

It’s only fair to share… MK 5204 CAS No: 1207751-75-4 Product Code: BM178545  (1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-20-(5-carbamoyl-1,2,4-triazol-1-yl)-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-17-oxapentacyclo[13.3.3.01,14.02,11.05,10]henicos-2-ene-6-carboxylic acid MF: C40H65N5O5 MW: 696g/mol MW 695.97 C40 H65 N5 O5 PAPER https://www.sciencedirect.com/science/article/abs/pii/S0960894X20304686 Abstract Our previously reported efforts to produce an orally active β-1,3-glucan synthesis inhibitor through the semi-synthetic modification of enfumafungin focused on replacing the C2 acetoxy moiety with an aminotetrazole and …

SELGANTOLIMOD

It’s only fair to share… SELGANTOLIMOD GS 9688 RN: 2004677-13-6 UNII: RM4GJT3SMQ Molecular Formula, C14-H20-F-N5-O, Molecular Weight, 293.344 1-Hexanol, 2-((2-amino-7-fluoropyrido(3,2-d)pyrimidin-4-yl)amino)-2-methyl-, (2R)- (2R)-2-((2-Amino-7-fluoropyrido(3,2-d)pyrimidin-4-yl)amino)-2-methylhexan-1-ol Discovery of GS–9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B Journal of Medicinal Chemistry, Articles ASAP (Drug Annotation) Publication Date (Web):May 14, 2020DOI: 10.1021/acs.jmedchem.0c00100 https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.0c00100/suppl_file/jm0c00100_si_002.pd PATENTS Patent ID …

Favipiravir, ファビピラビル

It’s only fair to share… FAVIPIRAVIR FAVIPIRAVIR Toyama (Originator) RNA-Directed RNA Polymerase (NS5B) Inhibitors Chemical Formula: C5H4FN3O2 CAS #: 259793-96-9 Molecular Weight: 157.1 ANTI-INFLUENZA COMPOUND clinical trials  http://clinicaltrials.gov/search/intervention=Favipiravir Chemical Name: 6-fluoro-3-hydroxy-2-pyrazinecarboxamide Synonyms: T-705, T705, Favipiravir Molecular FormulaC5H4FN3O2 Average mass157.103 Da 259793-96-9 [RN] 2-Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo- 6-Fluoro-3-hydroxypyrazine-2-carboxamide 6-Fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxamide 8916 Avigan ファビピラビル Favipiravir 6-Fluoro-3-hydroxypyrazine-2-carboxamide C5H4FN3O2 : 157.1 [259793-96-9] https://www.pmda.go.jp/files/000210319.pdf The drug …

Camostat Mesilate, カモスタットメシル酸塩 日局収載

It’s only fair to share… Camostat Molecular FormulaC20H22N4O5 Average mass398.413 Da 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester 4-{2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate 59721-28-7 [RN] Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester Camostat Mesilate カモスタットメシル酸塩 日局収載 Trypsin-like protease inhibitor CAS 59721-29-8 C20H22N4O5.CH4O3S 494.52 MP 194, methanol, diethyl ether, Chemical and Pharmaceutical Bulletin, 2005, vol. 53, 8, pg. 893 – 898 カモスタットメシル酸塩 日局収載 Camostat Mesilate Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate monomethanesulfonate C20H22N4O5▪CH4O3S : 494.52 [59721-29-8] Launched – 1985, in Japan …

Remdesivir, レムデシビル , ремдесивир , ريمديسيفير , 瑞德西韦 ,

It’s only fair to share…   Remdesivir Formula C27H35N6O8P CAS 1809249-37-3 Mol weight 602.576 レムデシビル UNII:3QKI37EEHE ремдесивир [Russian] [INN] ريمديسيفير [Arabic] [INN] 瑞德西韦 [Chinese] [INN] 2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) L-Alanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile 2-Ethylbutyl (2S)-2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate 2-Ethylbutyl (2S)-2-[[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate 2-Ethylbutyl N-[(S)-[2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitril-6-O-yl]phenoxyphosphoryl]-L-alaninate GS 5734 L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester,6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile GS-5734 Treatment of viral infections Phase III, clinical trials for the treatment …

LANRAPLENIB

It’s only fair to share… LANRAPLENIB GS-9876 Phase II, GILEAD Phase II Gilead Cutaneous lupus erythematosus Rheumatoid arthritis Sjogren syndrome GS-9876  LANRAPLENIB Imidazo(1,2-a)pyrazin-8-amine, 6-(6-amino-2-pyrazinyl)-N-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)- 6-(6-Aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo|1,2-a]pyrazin-8-amine 6-(6-Amino-2-pyrazinyl)-N-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)imidazo(1,2-a)pyrazin-8-amine Molecular Weight 443.50 Formula C₂₃H₂₅N₉O CAS No. 1800046-95-0 Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib (GS-9876) …

ABBV 744

It’s only fair to share…   ABBV 744 N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide 1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo- Molecular Weight 491.55 Formula C₂₈H₃₀FN₃O₄ CAS No. 2138861-99-9 ABBV-744 is a highly BDII-selective BET bromodomain inhibitor, used in the research of inflammatory diseases, cancer, and AIDS. Acute Myeloid Leukemia (AML) Phase I, AbbVie is evaluating oral agent ABBV-744 in early clinical trials for the treatment of metastatic castration …

NIDUFEXOR

It’s only fair to share… NIDUFEXOR LMB763 4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)amino]methyl]benzoic acid Nidufexor is a farnesoid X receptor (FXR) agonist. Molecular Weight 487.93 Formula C₂₇H₂₂ClN₃O₄ CAS No. 1773489-72-7 PHASE 2 Treatment of Liver and Biliary Tract Disorders, Agents for Diabetic Nephropathy, NOVARTIS Nidufexor 1773489-72-7, LMB-763, UNII-CJ1PL0TE6J, CJ1PL0TE6J, BCP28929, EX-A1854 Nidufexor pound LMB-763 pound(c) ZINC584641402 4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoic acid HY-109096 CS-0039398   https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01621 1 (7.6 g, 89% yield) as …

LNP 023

It’s only fair to share… LNP 023 CAS 1644670-37-0 ROTATION + 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid M.Wt 422.525 Formula C25H30N2O4 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid LNP023 RENRQMCACQEWFC-UGKGYDQZSA-N PATENT US9682968, Example-26a BDBM160475 ZINC223246892 HY-127105 CS-0093107 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid LNP023 (LNP-023) is a highly potent, reversible, selective inhibitor of factor B (IC50=10 nM), the proteolytically active component of the C3 and C5 convertases. …