Category «Uncategorized»

ACS INDUSTRY SYMPOSIUM , RECENT ADVANCES IN DRUG DEVELOPMENT HYDERABAD, INDIA, Dr. REDDYS, Nov 11-12 2016

It’s only fair to share… GROUP PICTURE Inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India Recent Advances in Drug Development ACS2016 ACS Symposium at Dr. Reddy’s Hyderabad, India, Nov 11-12 2016 ACS INDUSTRY SYMPOSIUM , RECENT ADVANCES IN DRUG DEVELOPMENT HYDERABAD, INDIA, http://acssymposium.org.in/  The American Chemical Society (ACS) hosted the inaugural ACS Industry Symposium …

Acetylcholine Chloride

It’s only fair to share… Acetylcholine Chloride 2-acetyloxyethyl(trimethyl)azanium;chloride 60-31-1 Molecular Formula: C7H16ClNO2 Molecular Weight: 181.66 g/mol Acetylcholine chloride is obtained as white or off-white hygroscopic crystals, or as a crystalline powder. The salt is odorless, or nearly odorless, and is a very deliquescent powder. Acetylcholine bromide is obtained as deliquescent crystals, or as a white …

Valdetamide

It’s only fair to share… CAS Registry Number: 512-48-1 CAS Name: 2,2-Diethyl-4-pentenamide Additional Names: diethylallylacetamide Trademarks: Novonal (Hoechst) Molecular Formula: C9H17NO Molecular Weight: 155.24 Percent Composition: C 69.63%, H 11.04%, N 9.02%, O 10.31% Literature References: Description: Bockmühl, Schaumann, Dtsch. Med. Wochenschr. 54, 270 (1928). Pharmacokinetics and metabolism: H. Uehleke, M. Brinkschulte-Freitas, Arch. Pharmacol. 302, 11 (1978). TLC determn in urine: E. Klug, P. Toffel, Arzneim.-Forsch. 29, 1651 (1979). Properties: White powder, mp …

PF 06273340

It’s only fair to share… PF-06273340 N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide CAS 1402438-74-7 Chemical Formula: C23H22ClN7O3 Molecular Weight: 479.925 Originator Pfizer ClassAnalgesics; Small molecules Mechanism of ActionUndefined mechanism 06 Oct 2014 Pfizer plans a phase I trial in Pain (In volunteers) in the Netherlands (NCT02260947) 07 Aug 2014 Discontinued – Phase-I for Pain (In volunteers) in Belgium (PO) 07 Aug 2014 Discontinued – …

BRD 2879

It’s only fair to share… BRD2879 BRD-K56962879-001-01-5 CAS 1304750-47-7 Chemical Formula: C30H38FN3O5S Molecular Weight: 571.7084 3-cyclohexyl-1-(((4R,5R)-8-((3-fluorophenyl)ethynyl)-2-((S)-1-hydroxypropan-2-yl)-4-methyl-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b][1,4,5]oxathiazocin-5-yl)methyl)-1-methylurea 3-cyclohexyl-1-[[(4R,5R)-8-[2-(3-fluorophenyl)ethynyl]-2-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,1-dioxo-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-5-yl]methyl]-1-methylurea BRD2879 is a potent and cell-active inhibitor of IDH1-R132H with a markedly different structure from previously reported probes with (IC50 = 50 nM for inhibiting IDH1-R132H enzyme). BRD2879 represents a new structural class of mutant IDH1 inhibitors that, …

PF 610355 Revisited

It’s only fair to share… PF-610355 Molecular Formula C34H39N3O6S Average mass 617.755 Da PF 610655, PF-00610355; PF-610,355 2-[3-[2-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(methylsulfonylamino)phenyl]ethyl]amino]-2-methyl-propyl]phenyl]-N-[[3-(4-hydroxyphenyl)phenyl]methyl]ethanamide 862541-45-5  cas Originator Pfizer Class Antiasthmatics; Benzeneacetamides; Sulfonamides Mechanism of Action Beta 2 adrenergic receptor agonists Orphan Drug StatusNo On Fast trackNo Highest Development Phases Discontinued Asthma; Chronic obstructive pulmonary disease Most Recent Events 11 Aug 2011 Discontinued – Phase-I for Asthma in Belgium (Inhalation) …

Solifenacin, солифенацин , سوليفيناسين , 索利那新 , コハク酸ソリフェナシン

It’s only fair to share… SOLIFENACIN, YM-905 MF C23H26O2, a molecular weigt  362.4647 CAS 242478-37-1 солифенацин [Russian] سوليفيناسين [Arabic] 索利那新 [Chinese] 242478-37-1 (Solifenacin ) 242478-38-2 (Solifenacin Succinate) Solifenacin succinate, YM-67905 コハク酸ソリフェナシン Molecular Formula: C11H19NO7S Formula Weight: 480.56 CAS 242478-38-2 Usage Muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence. Usage sedative Usage Solifenacin succinate is a urinary antispasmodic of the …

BMS-599793

It’s only fair to share… BMS-599793 (DS003, BMS-599793) Cas 676489-50-2 Molecular Formula: C27H22N6O3 Molecular Weight: 478.512 g/mol 2-[1-[2-(4-methoxy-7-pyrazin-2-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxo-acetyl]-4-piperidylidene]-2-phenyl-acetonitrile; 2-[1-[2-(4-methoxy-7-pyrazin-2-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetyl]piperidin-4-ylidene]-2-phenylacetonitrile; Piperidine, 4-(cyanophenylmethylene)-1-[2-(4-methoxy-7-pyrazinyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-; US 20040063744 , US 20040186292, WO 2009114313  Inventors Andrew S. Thompson, Hua Cheng, Stanislaw Pikul Applicant International Partnership For Microbicides Stanislaw Pikul   2-(1-(2-(4-methoxy-7-(pyrazin-2-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanoyl)piperidin-4- ylidene)-2-phenylethanenitrile 1 (DS003, BMS-599793) is a small molecule entry inhibitor that interferes with HIV infection by …

A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug

It’s only fair to share…       PAPER HETEROCYCLES An International Journal for Reviews and Communications in Heterocyclic Chemistry Web Edition ISSN: 1881-0942 Published online: 11th October, 2016 Paper | Regular issue | Prepress DOI: 10.3987/COM-16-13538 ■ A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug Zhezhou Yang, Lin Zhang, Huirong …