Category «Uncategorized»

SNS-032, BMS-387032 A potent and selective Cdk inhibitor

It’s only fair to share… SNS 032, BMS-387032 N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide Cas 345627-80-7, MP 165-167° C M.Wt:380.53, Formula:C17H24N4O2S2   SNS 032, BMS-387032 HYDROCHLORIDE Formula C17H24N4O2S2 . HCl MW 380.5 . 36.5 CAS 345627-90-9   A potent and selective Cdk inhibitor Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM …

Evofosfamide, эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 ,

It’s only fair to share…   Evofosfamide, HAP-302 , TH-302, TH 302 эвофосфамид ,  إيفوفوسفاميد ,  艾伏磷酰胺 , Molecular Formula C9H16Br2N5O4P Average mass 449.036 Da (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N’-bis(2-bromoethyl)phosphorodiamidate (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl-N,N’-bis(2-bromethyl)phosphorodiamidat 918633-87-1 TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs Originator Threshold Pharmaceuticals Developer Merck KGaA; Threshold Pharmaceuticals Class Antineoplastics; Nitroimidazoles; Phosphoramide mustards; Small …

PF-04136309

It’s only fair to share… PF 4136309 PF4136309; PF 4136309; PF-4136309; PF04136309; PF4136309; PF-04136309; INCB8761; INCB 8761; INCB-8761 (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide N-[2-[(3S)-3-[[trans-4-Hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)benzamide N-[2-((3S)-3-[4-hydroxy-4-(4-pyrimidin-2-ylphenyl)cyclohexyl]aminopyrrolidin-1-yl)-2- oxoethyl]-3-(trifluoromethyl)benzamide 1341224-83-6 MF: C29H31F3N6O3 MW: 568.24097 CC chemokine receptor 2 (CCR2) antagonist Pfizer Limited Gary Burgess PF-4136309, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating …

ミチグリニドカルシウム水和物 , Mitiglinide calcium hydrate, 快如妥/Glufast

It’s only fair to share… Mitiglinide MF C19H25NO3 MW 315.407 Da Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes.[1] Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals. …

Duloxetine Hydrochloride, MSN, PATENT, US. 8362279

It’s only fair to share… US. 8362279 http://www.google.co.in/patents/US8362279 Inventors Manne Satyanarayana Reddy, Muppa Kishore Kumar, Srinivasan Thirumalai Rajan,Durgadas Shyla Prasad,  Original Assignee Msn Laboratories Limited Synthesis of duloxetine is described in detail in EP-A-273 658, EP-A-457 559 and EP-A-650965, starting from 2-acetylthiophene, an aminomethylation with dimethylamine and formaldehyde (Mannich reaction) is carried out in step-A. …

CURCUMIN

It’s only fair to share… Curcumin Enol form Keto form Title: Curcumin CAS Registry Number: 458-37-7 CAS Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Additional Names: turmeric yellow; diferuloylmethane; C.I. 75300; C.I. Natural Yellow 3 Molecular Formula: C21H20O6 Molecular Weight: 368.38 Percent Composition: C 68.47%, H 5.47%, O 26.06% Literature References: Natural dyestuff from root of Curcuma longa L., Zingiberaceae. Isoln: Vogel, Ann. 44, 297 (1842); Perkin, Phipps, J. Chem. Soc. (Trans.) 85, I, 64 (1904); Rao, Shintre, J. Soc. …

(±)-SIPI 6360

It’s only fair to share… (±)-SIPI 6360 D2/5-HT2A receptor dual antagonist 7-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methyl-3,4-dihydro-1H-quinolin-2-one 2(1H)-Quinolinone, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3,4-dihydro-3-methyl- Molecular Formula: C25H28FN3O3 Molecular Weight: 437.506523 g/mol CAS 1401333-14-9 2(1H)-Quinolinone, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3,4-dihydro-3-methyl- ((±)-SIPI 6360) 7-(3-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methyl-3,4-dihydroquinolin-2(1H)-one ((±)-SIPI 6360) Mp 154–155 °C; 1H NMR (400 Hz, CDCl3) δ 8.41 (br, 1H), 7.70 (dd, J = 8.8, 5.2 Hz, 1H), 7.27–7.23 (m, 1H), 7.08–7.03 (m, …

Olanexidine, オラネキシジングルコン酸塩

It’s only fair to share… Olanexidine Gluconate OPB-2045G, Gluconate olanexidin,  Olanedine,  OPB-2045,  OPB 2045G,  (Olanedine®)Approved in Japan PMDA 2015-07-03, Olanedine® by Otsuka A disinfectant used to prevent of postoperative bacterial infections. CAS .146510-36-3(Olanexidine free form),  Imidodicarbonimidic diamide, N-((3,4-dichlorophenyl)methyl)-N’-octyl C17H27Cl2N5 Formula Weight: 372.341 CAS 799787-53-4(Olanexidine Gluconate) 568.49 Formula C17H27Cl2N5 ● C6H12O7 1-(3,4-Dichlorobenzyl)-5-octylbiguanide mono-D-gluconate オラネキシジングルコン酸塩 Olanexidine Gluconate C17H27Cl2N5▪C6H12O7 : 568.49 [799787-53-4] Indication:Bacterial infection …

Pitolisant Hydrochloride

It’s only fair to share…   Pitolisant 1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine MF  C17H26ClNO MW  295.1703 (Wakix®)Approved EU 31/3/2016, Narcolepsy A histamine H3 receptor antagonist/inverse agonist used to treat narcolepsy. BF-2649; BF-2.649; FUB-649, Ciproxidine, Tiprolisant CAS 362665-56-3, 362665-57-4 (oxalate)  CAS 903576-44-3(Pitolisant Hydrochloride) 1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine hydrochloride (1:1) Molecular Weight 332.31 Formula C17H26ClNO ● HCl Bioprojet INNOVATOR Jean-Charles Schwartz, Jeanne-Marie Lecomte Pitolisant (INN) or tiprolisant (USAN) is a histamine …

ROMIDEPSIN

It’s only fair to share…    Romidepsin; Depsipeptide; FK228; Chromadax; FR901228; Istodax; Molecular Formula: C24H36N4O6S2 Molecular Weight: 540.69584 g/mol CAS 128517-07-7 (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone (E)-N-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacteria Chromobacterium violaceum, and …