Category «Uncategorized»

Pepinemab, VX 15

It’s only fair to share… (Heavy chain) QVQLVQSGAE VKKPGSSVKV SCKASGYSFS DYYMHWVRQA PGQGLEWMGQ INPTTGGASY NQKFKGKATI TVDKSTSTAY MELSSLRSED TAVYYCARYY YGRHFDVWGQ GTTVTVSSAS TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTKTYT CNVDHKPSNT KVDKRVESKY GPPCPPCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGK (Light chain) DIVMTQSPDS …

AVASOPASEM MANGANESE

It’s only fair to share… AVASOPASEM Average: 518.83 Monoisotopic: 517.134397 Chemical FormulaC21H35Cl3MnN5 manganese(2+);(4S,9S,14S,19S)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(26),22,24-triene;dichloride Manganese, dichloro((4aS,13aS,17aS,21aS)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-7,11-nitrilo-7H-dibenzo(b,H)-5,13,18,21-tetraazacycloheptadecine-kappaN5,kappaN13,kappaN18,kappaN21,kappaN22)-, (pb-7-11-2344’3′)- CAS 435327-40-5 A superoxide dismutase mimetic. GC 4419 M-40419 SC-72325A For the Reduction of The Severity and Incidence of Radiation and Chemotherapy-Induced Oral Mucositis Avasopasem manganese, also known as GC4419, is a highly-selective small molecule mimetic of superoxide dismutase (SOD) …

Belzutifan

It’s only fair to share… Belzutifan CAS 1672668-24-4 383.34 g·mol−1  C17H12F3NO4S 3-[[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]oxy]-5-fluorobenzonitrile MK-6482, PT-2977, UNII-7K28NB895L, 7K28NB895L 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile 3-{[(1s,2s,3r)-2,3-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile GTPL11251, PT 2977 [WHO-DD], BDBM373040 FDA APPROVED 8/13/2021, Welireg To treat von Hippel-Lindau disease under certain conditions EMA Drug Information Disease/Condition Treatment of von Hippel-Lindau disease Active Substance 3-(((1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Status of Orphan Designation Positive Decision Date 2020-08-21 FDA approves belzutifan for cancers associated with von Hippel-Lindau disease On …

Naftopidil

It’s only fair to share… Naftopidil 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol C24H28N2O3, 392.49 CAS 57149-07-2 KT-611, Flivas, Avishot 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol Naftopidil (Flivas), BM-15275 Naftopidil CAS Registry Number: 57149-07-2 CAS Name: 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Additional Names: RS-1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol; 1-(2-methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine Manufacturers’ Codes: KT-611 Trademarks: Avishot (Kanebo); Flivas (Asahi) Molecular Formula: C24H28N2O3 Molecular Weight: 392.49 Percent Composition: C 73.44%, H 7.19%, N 7.14%, O 12.23% Literature References: a1-Adrenergic blocker and serotonin (5HT1A) receptor agonist. Prepn: E. C. Witte et al., DE 2408804; eidem, US 3997666 (1975, 1976 …

Pralnacasan

It’s only fair to share…   Pralnacasan VX 740 cas 192755-52-5 (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide N-[(4S,7S)-4-{[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]carbamoyl}-6,10-dioxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-yl]isoquinoline-1-carboxamide (1S,9S)-N-((2R,3S)-2-Ethoxy-5-oxotetrahydrofuran-3-yl)-9-((isoquinolin-1-ylcarbonyl)amino)-6,10-dioxooctahydro-6-H-pyridazino(1,2-a)(1,2)diazepine-1-carboxamide 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxamide, N-((2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl)octahydro-9-((1-isoquinolinylcarbonyl)amino)-6,10-dioxo-, (1S,9S)- HMR 3480 HMR3480 HMR3480/VX-740 Pralnacasan UNII-N986NI319S VX 470 VX-740 C26H29N5O7, 523.543 NSAID, ICE inhibitor & metastasis inhibitor. пралнаказан [Russian] [INN] برالناكاسان [Arabic] [INN] 普那卡生 [Chinese] [INN] Pralnacasan is an orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE). Pralnacasan is …

VX 148

It’s only fair to share… VX 148 297730-05-3 Name: VX-148 CAS#: 297730-05-3 Chemical Formula: C23H25N5O4 Exact Mass: 435.19065 Molecular Weight: 435.48 Elemental Analysis: C, 63.44; H, 5.79; N, 16.08; O, 14.70 Molecular Weight 435.48 Formula C23H25N5O4 CAS No. 297730-05-3 (VX 148); Chemical Name Carbamic acid, N-[(1S)-1-[3-[[[(4-cyano-3-methoxyphenyl)amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester MOA:Inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitorIndication:PsoriasisStatus:Phase Ⅱ (Discontinued)Company:Vertex (Originator) …

VX- ? (3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide)

It’s only fair to share… VX- ? CAS  2446817-72-5 HYDRATE 2446818-26-2 Acetic acid, 1-methylethyl ester 2446818-27-3 C21 H20 F N3 O3, 381.4 1H-Indole-3-propanamide, 2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]- 3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).   PATENT WO/2021/158666 SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME Compound I is disclosed as Compound 87 …

PROPOFOL

It’s only fair to share… Propofol CAS Registry Number: 2078-54-8 CAS Name: 2,6-Bis(1-methylethyl)phenol Additional Names: 2,6-diisopropylphenol; disoprofol Manufacturers’ Codes: ICI-35868 Trademarks: Ansiven (Abbott); Diprivan (AstraZeneca); Disoprivan (AstraZeneca); Rapinovet (Schering-Plough Vet.) Molecular Formula: C12H18O Molecular Weight: 178.27 Percent Composition: C 80.85%, H 10.18%, O 8.97% Literature References: Prepn: A. J. Kolka et al., J. Org. Chem. 21, 712 (1956); 22, 642 (1957); G. G. Ecke, A. J. Kolka, US 2831898 (1958 to Ethyl Corp.); …

IOHEXOL

It’s only fair to share… IOHEXOL CAS Registry Number: 66108-95-0 N1,N3-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide CAS Name: 5-[Acetyl(2,3-dihydroxypropyl)amino]-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Additional Names: N,N¢-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodoisophthalamide Manufacturers’ Codes: Win-39424; Compd 545 Trademarks: Omnipaque (GE Healthcare) Molecular Formula: C19H26I3N3O9 Molecular Weight: 821.14 Percent Composition: C 27.79%, H 3.19%, I 46.36%, N 5.12%, O 17.54% Literature References: Nonionic radio-contrast medium. Prepn: V. Nordal, H. Holtermann, DE 2726196; eidem, US 4250113 (1977, 1981 both to Nyegaard). HPLC-UV determn in plasma: R. S. …

ONO-2910

It’s only fair to share… ONO-2910 CAS 2410177-35-2 3- [2-[(E) -5- [3- (benzenesulfonamide) phenyl] penta-4-enoxy] phenyl] propanoic acid 3- [2-[(E) -5- [3- (benzenesulfonamido) phenyl] penta-4-enoxy] phenyl] propanoic acid C26 H27 N O5 S 465.56 Benzenepropanoic acid, 2-[[(4E)-5-[3-[(phenylsulfonyl)amino]phenyl]-4-penten-1-yl]oxy]- ONO Pharmaceuticals is developing ONO-2910 , the lead from a program of novel transient receptor potential cation channel 4/5 inhibitors, for treating …